Composite PHB/Chitosan Microparticles Obtained by Spray Drying: Effect of Chitosan Concentration and Crosslinking Agents on Drug Relesase

Lins, Luanda Chaves; Bazzo, Giovana Carolina; Barreto, Pedro Luiz Manique; Pires, Alfredo T. N.

doi:10.5935/0103-5053.20140129

Cited by 6 publications

(6 citation statements)

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“…The reason for this could be related to the higher degree of crosslinking between the primary amine groups on CS and GP, which could lead to a more rigid surface structure. 33 Increasing the nGO content from 0 to 2 wt % also generated a smooth surface; whereas further increasing nGO content to 10 wt % resulted in a surface with indentations. The CSderived nGO contains some oxygen functionalities including carboxylic, hydroxyl, and epoxy groups with the calculated C/ O ratio around 3.2; 31 hence, secondary intermolecular interactions such as H-bonding and electrostatic attractions could be formed between nGO and the CS matrix, leading to reinforcement of the network strength to resist shrinking during the solvent atomization process.…”

Section: ■ Results and Discussionmentioning

confidence: 95%

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Recyclable Fully Biobased Chitosan Adsorbents Spray-Dried in One Pot to Microscopic Size and Enhanced Adsorption Capacity

et al. 2019

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A facile one-pot spray-drying process was developed for fabrication and in situ crosslinking of chitosan microspheres to improve the adsorption capacity by microscopic design. A fully biobased nature was achieved by utilizing genipin (GP) as a crosslinking agent and chitosan-derived nanographene oxide (nGO) as a property tuner. The produced chitosan microspheres were further proven as powerful adsorbents for common wastewater contaminants such as anionic dyes and pharmaceutical contaminants, here modeled by methyl orange (MO) and diclofenac sodium (DCF). By regulating the amount of GP and nGO, as well as by controlling the process parameters including the spray-drying inlet temperature and postheat treatment, the surface morphology, size, zeta potential, and adsorption efficiency of the microspheres could be tuned accordingly. The adsorption efficiency for MO and DCF reached 98.9 and 100%, respectively. The microspheres retained high DCF adsorption efficiency after six adsorption and desorption cycles, and the recyclability was improved by the incorporated nGO. The fabricated microspheres, thus, have great potential as reusable and eco-friendly adsorbents.

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Section: ■ Results and Discussionmentioning

confidence: 95%

“…Increasing the amount of crosslinking agent from 5 to 10 wt % led to a remarkable change in the surface smoothness. The reason for this could be related to the higher degree of crosslinking between the primary amine groups on CS and GP, which could lead to a more rigid surface structure …”

Section: Resultsmentioning

confidence: 99%

Recyclable Fully Biobased Chitosan Adsorbents Spray-Dried in One Pot to Microscopic Size and Enhanced Adsorption Capacity

et al. 2019

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“…The process is performed using three or four fluid nozzles for incompatible biomaterials spraying, which enables the separation of them into core and shell layers [ 76 ]. The spray drying technique is also suitable for microparticle modification and surface coating, e.g., Lins et al adjusted a chitosan coating on drug-loaded polyhydroxybutyrate-based MPs to obtain composite MPs with a sustainable drug release [ 77 ], and Silva et al described shell layer formation with a drug encapsulation [ 78 ].…”

Section: Fabrication and Modification Of Polymeric-based Microparticl...mentioning

confidence: 99%

Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

et al. 2022

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Tissue engineering and cell therapy are very attractive in terms of potential applications but remain quite challenging regarding the clinical aspects. Amongst the different strategies proposed to facilitate their implementation in clinical practices, biodegradable microparticles have shown promising outcomes with several advantages and potentialities. This critical review aims to establish a survey of the most relevant materials and processing techniques to prepare these micro vehicles. Special attention will be paid to their main potential applications, considering the regulatory constraints and the relative easiness to implement their production at an industrial level to better evaluate their application in clinical practices.

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“…P(R)-HB [93][94][95][96][97], and bacterial copolymers such as P(3HB-co-4HB) [98][99][100], PHBV [101][102][103] or PHBH and derivatives [104][105][106], have been used for the elaboration of self-assembled systems such as DDSs, tissue engineering scaffolds and implants [107][108][109][110]. Those polymers have been chosen for their biodegradability and biocompatibility.…”

Section: Chemically Modified Bacterial Phb-based (Co)polymersmentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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Composite PHB/Chitosan Microparticles Obtained by Spray Drying: Effect of Chitosan Concentration and Crosslinking Agents on Drug Relesase

Cited by 6 publications

References 0 publications

Recyclable Fully Biobased Chitosan Adsorbents Spray-Dried in One Pot to Microscopic Size and Enhanced Adsorption Capacity

Recyclable Fully Biobased Chitosan Adsorbents Spray-Dried in One Pot to Microscopic Size and Enhanced Adsorption Capacity

Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

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