Leishmanicidal Galloylquinic Acids are Noncompetitive Inhibitors of Arginase

Sousa, Lorena Ramos Freitas de; Ramalho, Suelem D.; Fernandes, João B.; Silva, Maria Fátima das Graças Fernandes da; Iemma, Mônica Rosas da Costa; Corrêa, Caroindes Julia; Souza, Dulce Helena Ferreira de; Lima, Matheus P.; Vieira, Paulo C.

doi:10.5935/0103-5053.20140115

Cited by 7 publications

(8 citation statements)

References 2 publications

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“…Given that our study was focused on hydromethanolic extract compared to other extracts, galloylquinic acid derivatives were described in TG for the first time. They have already been reported as metabolites with biological properties that include antioxidant, leishmanicidal, anti-HSV-1, and anti-allergy bioactivities [41,42]. Our work also highlights the presence of isorhamnetin for the first time.…”

Section: Discussionsupporting

confidence: 62%

Polyphenol Composition and Antioxidant Activity of Tapirira guianensis Aubl. (Anarcadiaceae) Leaves

Patient

Jean-Marie

Robinson

et al. 2022

Plants

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Tapirira guianensis (Anacardiaceae) is a natural resource from the Amazonian Forest and is locally known in French Guiana as “loussé” (creole), “tata pilili” (wayãpi), or “ara” (palikur). The tree is used by indigenous populations for medicinal purposes. To increase the potential of this tree for cosmetic, agro-food, or pharmaceutical uses, extracts were obtained through ultrasound-assisted extraction (UAE) from T. guianensis leaves using various extraction solvents such as water, methanol, and methanol–water (85/15; v/v). Chemical (DPPH, TEAC, ORAC) tests were applied to assess the anti-radical potential of these extracts. The polyphenol contents were determined by spectrophotometric (UV/Visible) and by means of chromatographic (UPLC-DAD-ESI-IT-MSn) methods. Tapirira guianensis leaf hydromethanolic extract produced the highest polyphenol content and exhibited antiradical activities in chemical assays (DPPH, TEAC, and ORAC) similar to (or higher than) those of a well-known antiradical plant, green tea. In T. guianensis, two classes of polyphenols were evidenced: (1) galloylquinic acids (identified for the first time in the studied species) and (2) flavonols and flavanols (present in small amounts). Flavonols seemed to play a major role in the antioxidant activity of DPPH. These findings provide a rationale for the use of T. guianensis in traditional medicine and to pave the way for seeking new biological properties involving this Amazonian tree.

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Section: Discussionsupporting

confidence: 62%

Polyphenol Composition and Antioxidant Activity of Tapirira guianensis Aubl. (Anarcadiaceae) Leaves

Patient

Jean-Marie

Robinson

et al. 2022

Plants

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“…Darora residents regularly use the two Byrsonima species as medicinal products for digestive disorders, such as diarrhea and dysentery. This finding is in accordance with an extensive scientific documentation about the medicinal use of Byrsonima spp., including their anti-inflammatory, antimicrobial and Use and traditional knowledge of Byrsonima crassifolia and B. coccolobifolia (Malpighiaceae) in a Makuxi community of the Roraima savanna, northern Brazil ACTA AMAZONICA antioxidant activities (Sannomiya et al 2005;Michelin et al 2008;Sousa et al 2014). Some specific examples are the molluscidal action of Byrsonima coccolobifolia against Biomphalaria glabrata, and its effective bactericidal action against Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Escherichia coli (Alves et al 2000;Pereira 2011).…”

Section: Discussionmentioning

confidence: 99%

Use and traditional knowledge of Byrsonima crassifolia and B. coccolobifolia (Malpighiaceae) in a Makuxi community of the Roraima savanna, northern Brazil

2017

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Byrsonima crassifolia and B. coccolobifolia, popularly known as mirixis, muricis, mantecos or nances, are common fruit species in the Amazonian savannas. Their fruits are used in the preparation of juices and other beverages, while the other parts of the plants are used for different purposes in some indigenous communities. The aim of the present ethnobotanical study was to investigate the knowledge and traditional uses of mirixis in the Darora Indigenous Community, of the Makuxi ethnicity, in the São Marcos Indigenous Land, state of Roraima, northern Brazil. The knowledge on these species among the residents was analyzed considering their gender and age. A survey was carried out by means of semi-structured interviews with 60 respondents (36 men and 24 women), between 18 and 84 years of age. Data from the interviewees was compared between genders and two age groups (< 40 and ≥ 40 years of age). Ethnobotanical indices (Informant diversity value; Informant equability value) were calculated, and no significant differences were found in the diversity of uses between genders (U = 283.0000, p > 0.05) and age groups (U = 359.5000, p > 0.05), indicating that the knowledge on the species is evenly distributed among residents. Results show that both species are used for different purposes in the food, fuelwood and medicinal categories in the Darora Community, and this knowledge is widely shared among adult men and women of all ages.

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“…The chemical shifts are given as δ (ppm) using TMS as an internal standard. The isolated compounds were identified by comparing 1 H NMR data (Table S1) with literature data (Gottlieb et al, 1991;Motta et al, 2017;Nishimura et al, 1984;Souza et al, 2014;Nishizawa et al, 1989;Neszmélyi et al, 1993;Srinivasan et al, 2008).…”

Section: Chemical Characterizationmentioning

confidence: 99%

Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity

Sannomiya

Rodrigues

Oliveira

et al. 2022

Journal of Ethnopharmacology

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Leishmanicidal Galloylquinic Acids are Noncompetitive Inhibitors of Arginase

Cited by 7 publications

References 2 publications

Polyphenol Composition and Antioxidant Activity of Tapirira guianensis Aubl. (Anarcadiaceae) Leaves

Polyphenol Composition and Antioxidant Activity of Tapirira guianensis Aubl. (Anarcadiaceae) Leaves

Use and traditional knowledge of Byrsonima crassifolia and B. coccolobifolia (Malpighiaceae) in a Makuxi community of the Roraima savanna, northern Brazil

Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity

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