Electrochemical Oxidation of Chlorhexidine and its Amperometric Determination by Flow-Injection Analysis

Lima, Ana P.; Stefano, Jéssica S.; Montes, Rafael Marangoni; Cunha, Rafael R.; Silva, Luiz A. J.; Richter, Eduardo M.; Muñoz, Rodrigo A.A.

doi:10.5935/0103-5053.20130267

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“…The main electrochemical features of CHX in the mixture CNTs/AgNPs/CHX2% were slightly shifted concerning the potential values (0.386 V, 0.632 V, and 0.967 V), while the first two oxidation peaks of CHX alone (at 0.267 V, 0.427 V) might be merged into one single peak in the case of the mixture (at 0.386 V). According to the literature [ 36 , 37 , 38 ], CHX oxidation leads to two p-chloraniline and two biguanidine molecules.…”

Section: Resultsmentioning

confidence: 99%

Carbon Nanotubes for Improved Performances of Endodontic Sealer

et al. 2021

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In order to overcome the limitations of current endodontic sealers, especially against resistant bacteria, recent developments in the field of nanotechnology have proved the necessity to reconsider the composition and physico-chemical properties of classical sealers. Nanoparticles with their unique features in terms of small size and high specific surface area, are the best choice for incorporation of antiseptic agents and effective delivery. The aim of our study is to prepare a novel platform for antibacterial drug delivery in dental adhesive systems used in endodontics. For this purpose, multi-walled carbon nanotubes (MWCNTs) encapsulating chlorhexidine (CHX) and colloidal silver nanoparticles (AgNPs) were prepared and incorporated into commercial sealer and investigated in terms of bonding performance to dentin and effectiveness against E. faecalis, S. aureus and Candida albicans, which are responsible for the majority of the failures in endodontic treatments. In this context, the challenges related to the long-term biological effects of CHX/AgNPs loaded MWCNTs are discussed.

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Section: Resultsmentioning

confidence: 99%