Aporphine and Tetrahydroprotoberberine Alkaloids from the Leaves of<i>Guatteria friesiana</i>(Annonaceae) and their Cytotoxic Activities

Costa, Emmanoel V.; Cruz, Pedro Ernesto Oliveira da; Pinheiro, Maria Lúcia B.; Marques, Francisco A.; Ruiz, Ana Lúcia Tasca Góis; Marchetti, Gabriela M.; Carvalho, João Ernesto de; Barison, Andersson; Maia, Beatriz Helena Lameiro de Noronha Sales

doi:10.5935/0103-5053.20130103

Cited by 7 publications

(9 citation statements)

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“…Guatteria genus belongs to the Annonaceae family and is widely-distributed in the Amazonian region of Brazil, as well as in Colombia. Costa et al suggested that plants from this genus are rich in alkaloids with promising biological activities (3). Among them a quaternary alkaloid called palmatine (PA) isolated from G. friesiana leaves is reported to have anti-inflammatory and anticancer effects (4).…”

Section: Introductionmentioning

confidence: 99%

Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment

Chaves¹,

Afzal²,

Islam³

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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There is evidence that palmatine (PA), an alkaloid isolated from the Guatteria friesiana plant, has some important biological activities, including antiinflammatory and antidepressant effects. In this study, the antioxidant and anti-acetylcholinesterase (AChE) effects of PA were assessed. The antioxidant capacity was evaluated in vitro and in vivo through 7 distinct assays, and the anti-AChE activity was determined in vitro. The standards, trolox and ascorbic acid were used for the in vitro antioxidant test, while hydrogen peroxide was selected as a stressor for the Saccharomyces cerevisiae test. Additionally, PA was also combined with trolox and ascorbic acid to determine the likelihood of synergistic effects occurrence to what concerns to antioxidant potential. PA exhibited a potent and concentration-dependent antioxidant potential, although a stronger antioxidant activity was stated using the PA + trolox combination. PA was also found to inhibit AChE activity when compared to the negative control. Thus, PA may be viewed as a promissory phytotherapeutic agent to manage oxidative stress-mediated neurological diseases, especially the Alzheimer's and Parkinson's diseases.

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Section: Introductionmentioning

confidence: 99%

Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment

Chaves¹,

Afzal²,

Islam³

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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“…In Brazil, 385 identified species are catalogued, with most occurring in the Amazonian domain . Some of them are known for their medicinal properties, as supported by previous investigations revealing bioactive compounds showing potential anticancer, − antimicrobial, ,,− antioxidant, and antiparasitic activities. , Guatteria friesiana (W.A. Rodrigues) Erkens & Maas is known popularly as “envireira” or “envira”, and previous phytochemical investigations have described the chemical constituents of its essential oil ,, as well as aporphine alkaloids found in its leaves and stem. , In a continuing search for bioactive compounds from Amazonian annonaceous plants, 12 new ( 1 – 12 ) and nine previously described ( 13 – 21 ) alkaloids were obtained in a systematic activity-guided investigation of the bark of G. friesiana .…”

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confidence: 94%

7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

et al. 2016

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“…Berberine was also tested for inhibition of melanoma cancer cells, e.g., mouse melanoma B16 cells [ 12 ], B16F10 cells [ 13 ], human melanoma A375 cell line [ 14 ], human melanoma A375.S2 and A375.S2/PLX cells [ 15 ]. Palmatine and its analogues also possessed anticancer activity against, e.g., 7701QGY, SMMC7721, HepG2, CEM, CEM/VCR, KIII, Lewis cell lines [ 16 ], MCF-7 (breast cancer) [ 17 ]. Magnoflorine anticancer activity was investigated against, e.g., NCI-H1299 lung, MDA-MB-468 breast, T98G glioma, and TE671 rhabdomyosarcoma cancer cells [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Cytotoxic Activity of Selected Isoquinoline Alkaloids and Plant Extracts Obtained from Various Parts of Mahonia aquifolium Collected in Various Vegetation Seasons

et al. 2021

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Melanoma is a serious form of skin cancer that begins in cells known as melanocytes. While it is less common than the other forms of skin cancer, melanoma is more dangerous because of its ability to spread to other organs more rapidly if it is not treated at an early stage. The number of people diagnosed with melanoma has increased over the last few decades. The most widely used treatments include surgery, chemotherapy, and radiation therapy. The search for new drugs to treat various cancers is one of the most important challenges of modern scientific research. Some isoquinoline alkaloids found in different plant species have strong cytotoxic effects on various cancer cells. We tested the effect of isoquinoline alkaloids and extracts obtained from various parts of Mahonia aquifolium collected in various vegetation seasons on human melanoma cancer cells and our data indicated that investigated extract induced significant reduction in cell viability of Human malignant melanoma cells (A375), human Caucasian malignant melanoma cell line (G361), and human malignant melanoma cell line (SKMEL3 cancer cell lines in a dose- and time-dependent manner. Differences in cytotoxic activity were observed for extracts obtained from various parts of Mahonia aquifolium. Significant differences were also obtained in the alkaloids content and cytotoxic activity of the extracts depending on the season of collection of plant material. Our investigations exhibit that these plant extracts can be recommended for further in vivo experiments in order to confirm the possibility of their use in the treatment of human melanomas.

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Aporphine and Tetrahydroprotoberberine Alkaloids from the Leaves ofGuatteria friesiana(Annonaceae) and their Cytotoxic Activities

Cited by 7 publications

References 0 publications

Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment

Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment

7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

Determination of Cytotoxic Activity of Selected Isoquinoline Alkaloids and Plant Extracts Obtained from Various Parts of Mahonia aquifolium Collected in Various Vegetation Seasons

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