Clerodane Diterpenes from Bark of<i>Croton urucurana</i>Baillon

Pizzolatti, Moacir Geraldo; Bortoluzzi, Adaílton J.; Brighente, Inês Maria Costa; Zuchinalli, Analice; Carvalho, Francieli Kanumfre de; Cândido, Ana Carina S.; Peres, Marize Terezinha Lopes Pereira

doi:10.5935/0103-5053.20130075

Cited by 6 publications

(5 citation statements)

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“…259,260 2.4.2. Type IV subtype II other compounds 84,108,132,157,165,214,235,257,[263][264][265][266][267][268][269][270][271][272][273][274] (Table 20 compounds 656-691 found in ESI †). Compound 665 from Salvia divinorum is a C-17 epimeric mixture of the hemiacetal salvinorin J, and is an example of a neo-clerodane hemiacetal (lactol) susceptible to mutarotation with the formation of an equilibrium mixture of C-17 epimers.…”

Section: Type I With An Acyclic Side Chain At C-9mentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.

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Section: Type I With An Acyclic Side Chain At C-9mentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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“…The chemistry of Croton genus shows a high diversity of structures: diterpenes of different skeletons including crotofolanes (Chávez et al, 2013;Kawakami et al, 2015), clerodanes (Pizzolatti et al, 2013;Aldhaher et al, 2017;Qiu et al, 2018), kaurenes (Mora et al, 2011;Mateu et al, 2012;Pereira et al, 2012), labdanes (Bernardino et al, 2017), the more important structures in many species (Xu et al, 2018;Shi et al, 2018). Terpenes (Palmeira Júnior et al, 2006); alkaloids and flavonoids are also common in the genus (de Araújo- Júnior et al, 2004;Suárez et al, 2004;Cerqueira-Coelho et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Suárez

Morocho

Luna

et al. 2021

Revista De La Facultad De Farmacia

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Phytochemical study of two medicinal plants from Ecuador, Tagetes terniflora Kunth, and Croton rivinifolius Kunth, led to the isolation and characterization of the major constituents present in the organic extracts obtained from these plants: 5-(4-acetoxy-1-butynil)-2,2’-bi-thiophene (1), 5-methyl-2,2’:5’,2”- terthiophene (2), patuletin (3) from Tagetes terniflora, and isocorydine (4), sweroside (5), tiliroside (6) from Croton rivinifolius. The structures of these compounds were established by spectroscopic analysis including two-dimensional NMR methods, MS, and comparison with published spectral data. They are recognized as secondary metabolites that represent the chemotaxonomy of Tagetes and Croton genera and could be responsible for the recognized medicinal properties attributed to these species. This paper deals with the first report that shows the presence of these compounds in these plants.

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“…Os estudos realizados com espécies de Croton têm mostrado uma alta diversidade de estruturas químicas: terpenos (KAWAKAMI et al, 2015;CHAVEZ et al, 2013;PIZZOLATTI et al, 2013;ALDAHAER et al, 2017;QIU et al, 2018;MORA et al,2011;MATEU et al, 2012;PEREIRA et al, 2012;BERNARDINO et al, 2017;PALMEIRA et al, 2006;TENE et al, 2009), alcalóides e flavonóides também são comuns no gênero (ARAUJO-JUNIOR et al, 2004;SUÁREZ et al, 2004).…”

Section: Introductionunclassified

Avaliação Da Segurança Não Clínica Do Triterpeno Ácido Acetil Aleuritólico (Aaa) Isolado De Croton Zehntneri Em Zebrafish (Danio Rerio) Adulto

Bezerra

Ferreira

Silva

et al. 2020

BJD

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Este trabalho busca a avaliação da segurança não clínica do triterpeno AAA frente aos ensaios com zebrafish (Danio rerio) adulto. O triterpeno AAA foi isolado da raiz de Croton zehntneri. Soluções desta substância foram preparadas com salina 0,9 %, nas concentrações de (4,0 mg/kg ou 12 mg/kg ou 40 mg/kg; 20 μL i.p) e submetidas ao teste de toxicidade aguda frente ao modelo zebrafish. As mesmas doses foram investigadas quanto ao possível efeito ansiolítico, através do teste de campo aberto. As três dosagens de AAA testadas não foram tóxicas nos zebrafish e não reduziram a atividade locomotora do animal, tendo assim uma possível ação nociceptiva pois a amostra não alterou a atividade locomotora dos animais.

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Clerodane Diterpenes from Bark ofCroton urucuranaBaillon

Cited by 6 publications

References 0 publications

Clerodane diterpenes: sources, structures, and biological activities

Clerodane diterpenes: sources, structures, and biological activities

Chemical constituents of two Ecuadorian medicinal plants, Tagetes terniflora Kunth and Croton rivinifolius Kunth

Avaliação Da Segurança Não Clínica Do Triterpeno Ácido Acetil Aleuritólico (Aaa) Isolado De Croton Zehntneri Em Zebrafish (Danio Rerio) Adulto

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