Current distribution pattern of biopsy-proven glomerular disease in Salvador,
            Brazil, 40 years after an initial assessment

dos-Santos, Washington L. C.; Sweet, Glória Maria Maranhão; Azevêdo, Labene Gondim; Tavares, Maria Brandão; Soares, Maria Fernanda; Melo, Caroline Vilas Boas de; Carneiro, Márcia Fernanda Melo; Santos, Rilma Ferreira de Souza; Conrado, Márcia Cristina; Braga, Daniela Teixeira Leal; Bessa, Marcia Carvalho; Junior, Nathanael de Freitas Pinheiro; Bahiense-Oliveira, Marilia

doi:10.5935/0101-2800.20170069

Cited by 10 publications

(7 citation statements)

References 2 publications

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“…8,16 This also applies to the data of comparable studies worldwide. 9,18,19 Nevertheless, we reported impaired renal function as the next common clinical presentation in accordance with Jeganathan et al 20 On the contrary, Polito et al 19 reported urinary abnormalities as the second common clinical indication to perform renal biopsy after nephrotic syndrome. Moreover, other studies reported higher rates of nephritic syndrome and chronic kidney disease than ours, in addition to different clinical presentations such as acute renal failure, rapidly progressive GN, isolated proteinuria and/or hematuria.…”

Section: Discussionsupporting

confidence: 87%

Factors affecting the distribution of glomerulonephropathies among adult Saudi patients: A single-center, biopsy-based clinico-pathological study

hafez¹,

Elesawy²,

Abdelaziz³

et al. 2019

ACHR

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Introduction: Glomerulonephropathies (GNs) have high burden of morbidity and mortality worldwide. The distribution GNs varies significantly due to several factors. Materials and Methods: This retrospective clinico-pathological study estimates the biopsy-proven distribution of primary and secondary GNs and detects the predominant patterns among adult patients who underwent renal biopsy at Nephrology Centre, King Abdul-Aziz Specialist Hospital, Taif City, Kingdom of Saudi Arabia (KSA) from 2008 to 2013 with comparing data to other KSA studies and to other countries. Analysis of possible contributing factors for variation is provided. Relevant patients' data were collected from hospital records. Renal biopsies stained with H&E, Periodic Acid Schiff (PAS), Gomori Methenamine Silver (GMS), Masson Trichrome (MT) and immunofluorescence (IF) were examined and categorized according to the World Health Organization (WHO) classification of glomerular diseases. Comparisons to other studies were set. Results: Primary and secondary GNs comprised 59.4% and 40.6%. Focal segmental glomerulosclerosis (FSGS) was the commonest primary GN (29.3%), followed by minimal change disease (MCD, 22%) then membranous glomerulonephropathy (MGN, 19.5%). IgA nephropathy was the least frequent (IgAN, 2.4%). Lupus nephritis (LN) was the commonest secondary GN (75%), followed by diabetic and vascular nephropathies (DN, 17.9% ; VN, 7.1%). Spatial and temporal variations in GNs distribution existed locally and worldwide. Conclusion:Factors including selection criteria; biopsy rate and indications; local facilities; demographic distribution; racial, ethnic and genetic differences; and prevalence of etiological factors contribute to the variations of GNs distribution. National renal biopsy registry is recommended for obtaining correct distribution of GNs leading to proper prevention and treatment.

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Section: Discussionsupporting

confidence: 87%

Factors affecting the distribution of glomerulonephropathies among adult Saudi patients: A single-center, biopsy-based clinico-pathological study

hafez¹,

Elesawy²,

Abdelaziz³

et al. 2019

ACHR

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“…Brkovic et al [ 30 ] compared 1987-2006 and 2007-2014 and reported an increase in MN and a reduction in non-IgA mesangioproliferative nephropathy over time, with no change in the frequency of other primary glomerulopathies. Dos-Santos et al [ 31 ] showed an increase in the prevalence of FSGS between 1975 and 2006 and of LN and MN between 2006 and 2015, with a tendency for the prevalence of FSGS to decrease in this last period. It is likely that these temporal variations correlate with the heterogeneity of biopsy indications in different centres, changes in the population profile (for example, increasing age and ethnic variations), changes in lifestyle and socioeconomic diversity, all of which influence the epidemiological status of glomerulopathies and their variation over time.…”

Section: Discussionmentioning

confidence: 99%

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

et al. 2021

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Background The prevalence and distribution of glomerular diseases differ among countries, and the indication to perform a kidney biopsy varies among centres. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnoses, and the correlation between glomerulopathies and demographic and clinical data was evaluated. Methods In this study, 1051 kidney biopsies were retrospectively reviewed between 2000 and 2018. Patient demographic, clinical and laboratory data were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulointerstitial diseases (TIDs), hereditary nephropathies (HNs) and other diagnoses, were determined. The frequency of primary and secondary glomerulopathies was evaluated by age group, and the temporal variation in frequencies across three time periods (2000-2005, 2006-2011, and 2012-2018) was reported. Results The prevalence of SG predominated (52.4%), followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). Among the primary forms of glomerular disease, focal segmental glomerulosclerosis (FSGS) was the most common (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) was most common in patients with SG, followed by diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in patients with PG and also in patients with DRD and 2nd FSGS, whereas in patients with IgAN and SV, nephritic syndrome was the main presentation. For the age group between 18 and 50 years, LN, FSGS and IgAN predominated; for patients aged between 51 and 65 years, the proportion of DKD and 2nd FSGS increased, and SV was more common in patients > 65 years. The temporal variation in PG across the three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS over time (p < 0.001). In SG, there was a reduction in LN (p = 0.027) and an increase in DKD (p < 0.001) over time, with a tendency for 2nd FSGS to decrease over time (p = 0.053). Conclusions In the studied kidney biopsy registry, FSGS and IgAN were the most prevalent diagnoses in patients with PG, and LN and DKD were the most prevalent in patients with SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation in glomerulopathies, there was a reduction in FSGS and an increase in IgAN in patients with PGs over time, and for patients with SGs, there was a reduction in LN with an increase in cases of DKD over time.

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“…Over three time periods, we observed a signi cant reduction in FSGS and an increase in IgAN in the primary forms, and in the secondary, there was a reduction in LN and an increase in DKD, with a minor and nonsigni cant variation in the other glomerulopathies. 31 showed an increase in the prevalence of FSGS between 1975, and of LN and MN between 2006-2015, with a tendency for FSGS to decrease in this last period. It is likely that these temporal variations correlate with the heterogeneity of biopsy indication in different centers, changes in the population pro le (for example, increasing age and ethnic variations), changes in lifestyle and socioeconomic diversity, in uencing the epidemiological status of glomerulopathies and their variation over the years.…”

Section: Discussionmentioning

confidence: 93%

The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

Thomé

Bianchini

Bringhenti

et al. 2021

Preprint

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Background The prevalence and distribution of glomerular diseases differs between countries, and the indication to perform a kidney biopsy varies in each center. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnosis, and their correlation with demographic and clinical data were evaluated. Methods It was included in the study 1051 kidney biopsies retrospectively reviewed between the years 2000 to 2018. Demographic, clinical and laboratory data of patients were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulo-interstitial diseases (TID), hereditary nephropathies (HN) and other diagnosis, were described. The frequency of primary and secondary glomerulopathies was evaluated by age group, and their temporal variation in three time periods (2000–2005, 2006–2011, and 2012–2018) were reported. Results The prevalence of SG predominated (52.4%) followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). In primary forms, focal segmental glomerulosclerosis (FSGS) prevailed (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) had the highest frequency in SG, and in sequence diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in PG, and also in DRD and 2nd FSGS, whereas in IgAN and SV the nephritic syndrome was the main form of presentation. In the age group between 18–50 years, LN, FSGS and IgAN predominated, between 51–65 years the proportion of DKD and 2nd FSGS increased, and SV were more found in patients > 65 years. The temporal variation of PG in three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS (p < 0.001). In SG, there were a reduction in LN (p = 0.027) and increase in DKD (p < 0.001), with a tendency to decrease of 2nd FSGS (p = 0.053). Conclusions In this kidney biopsy registry, FSGS and IgAN were the prevalent diagnoses in PG, and LN and DKD in SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation of glomerulopathies, there was a reduction in FSGS and an increase in IgAN in PGs, and in SGs a reduction of LN with an increase in cases of DKD.

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Current distribution pattern of biopsy-proven glomerular disease in Salvador, Brazil, 40 years after an initial assessment

Cited by 10 publications

References 2 publications

Factors affecting the distribution of glomerulonephropathies among adult Saudi patients: A single-center, biopsy-based clinico-pathological study

Factors affecting the distribution of glomerulonephropathies among adult Saudi patients: A single-center, biopsy-based clinico-pathological study

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

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