Microalbuminuria in non diabetic population as an marker of nephropathy

Rodrigues, Marcos Marques; Dias, Cristiane Bitencourt

doi:10.5935/0101-2800.20160029

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…The disease results in hypoxia of tissues, increase of blood viscosity, vascular disease, increase of permeability of glomerular basement membrane, and glomerular damage mainly caused by microvascular disease [ 25 ]. Several studies show that the detection of UmAlb is a sensitive index for the diagnosis of early renal injury, and it is also the earliest clinical manifestation of diabetic renal microvascular damage [ 26 – 29 ]. GDM-related research points out that the UmAlb level of GDM patients is higher than that of normal pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Urinary Peptides Associated Closely with Gestational Diabetes Mellitus

Tian

et al. 2020

Disease Markers

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Gestational diabetes mellitus (GDM) is a common disease of pregnant women, which has a higher incidence in recent years. The purpose of this study is to explore urinary biomarkers that could predict and monitor gestational diabetes mellitus (GDM). Urine samples from 30 normal pregnant women and 78 GDM patients were collected and purified by weak cationic exchange magnetic beads (MB-WCX), then analyzed by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). The urinary peptide signatures of the two groups were compared by BioExplorer software. The potential ability of the differently expressed peptides to distinguish GDM patients from normal pregnant women was evaluated by receiver operating characteristic (ROC) analysis. At last, the differently expressed peptides were identified by liquid chromatography tandem mass spectrometry (LC-MS). There were four differently expressed peptides (m/z 1000.5, 1117.5, 1142.9, and 2022.9) between two groups, which were identified as fragments of urinary albumin, α2-macroglobulin, human hemopexin, and α1-microglobulin, respectively. The diagnostic efficacy of m/z 1142.9 was better than the other peptides. The area under the curve (AUC) of the m/z 1142.9 was 0.690 (95% CI: 0.583-0.796). The discovery of urinary polypeptides provides the possibility for the early prediction of GDM and the monitoring of glucose metabolism in GDM patients by a noninvasive method.

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Section: Discussionmentioning

confidence: 99%

Urinary Peptides Associated Closely with Gestational Diabetes Mellitus

Tian

et al. 2020

Disease Markers

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“…Lo anterior hace que se le considere como un marcador sensible para la disfunción renal progresiva y también como un factor de riesgo independiente para la morbilidad y la mortalidad cardiovascular (9). Además, la proteinuria se asocia a resultados adversos en pacientes con enfermedad renal crónica, con o sin diabetes (10) La proteinuria está definida por la presencia de proteínas en la orina. En los adultos se refiere a una excreción urinaria de estas superior a 150 mg en 24 horas.…”

Section: Definiciónunclassified

Análisis de laboratorio e interpretación

Ramos¹,

Cuno²

2022

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Los enfermos y la enfermedad, un binomio que requiere del estudio de los exámenes de laboratorio y la correcta interpretación de los resultados, los cuales pueden estar sujetos a errores de procesamiento por descalibración de los equipos de laboratorio ya sea a partir de los errores humanos o en la toma de muestras. Es así que se hace necesario el cotejo con la historia clínica del paciente, por la cambiante evolución de la enfermedad y por la concurrencia de otras patologías o cuadro de fondo que pudiera enmascarar el verdadero cuadro patológico. Se entiende entonces la importancia de considerar todas las circunstancias que rodean al enfermo, como los antecedentes patológicos (datos obtenidos del historial) los que sirven para una correcta interpretación del cuadro que aqueja al enfermo. Los exámenes de laboratorio son pruebas basadas en el estudio de muestras de fluidos y tejidos corporales permiten determinar estados biológicos y bioquímicos. Los datos obtenidos se reportan en forma escrita o por virtual, previo registro en el gabinete de trabajo. Éstos sirven para confirmar o descartar diagnósticos, determinar y controlar tratamientos e identificar la evolución de eventos fisiopatológicos. Los valores normales dependen del método, los reactivos químicos utilizados, la toma de la muestra, la conservación, su manipulación correcta y el cuidadoso traslado que evite la contaminación. Una práctica común al momento de atender pacientes en los servicios de salud consiste en que el personal médico solicite los exámenes de laboratorio. Por su parte, el personal de enfermería se encarga de acompañar al paciente para el cumplimiento de lo solicitado, la toma de muestras. El personal de laboratorio se encarga de la toma y apenas se tienen los resultados la enfermera toma conocimiento debe saber interpretarlos con la finalidad de comunicar de manera urgente al personal médico. Dependiendo de las circunstancias, si representa una emergencia o no, para tomar acciones conjuntas con los otros profesionales de salud, de manera que se pueda revertir el peligro y coadyuvar a mantener la homeostasis del enfermo. Es así que se presenta este manual de consulta rápida como herramienta tanto para los profesionales como los estudiantes y puedan realizar una interpretación fácil de los exámenes de laboratorio.

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“…Hyperperfusuion to the glomerulus and hypertrophy of the renal calyces occurs in initial phase after onset of diabetes mellitus, which is reflected by increase in glomerular filtration rate (GFR). [6][7][8] Screening of microalbumin can be done using quantitative methods including measurement of albumin to creatinine ratios in random sample of urine, 24 -hour collection with creatinine, which allows the simultaneous measurement of creatinine clearance, timed (e.g. 4 hourly) overnight collection of urine for protein, or it can be measured using semi -quantitative reagent dipsticks.…”

Section: Introductionmentioning

confidence: 99%

Microalbuminuria and its association with glycemic control in patients with diabetes mellitus type II.

Jiskani¹,

Singh²,

Meghji³

et al. 2020

TPMJ

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Diabetes mellitus is chronic condition with defect in regulation of insulin. Microalbuminuria is one of the early appearing markers of overt diabetic nephropathy. Uncontrolled glycemic status has been postulated to be associated with increase urinary albumin levels. Objectives: To find out the association of increased urinary albumin with poor glyemic status of patients with diabetes mellitus type II. Study Design: Cross Sectional study. Setting: Department of Pathology, Indus Medical College Hospital Tando Muhammad Khan. Period: November 2018 to June 2019. Material & Methods: Patients were divided into two groups: Group I (Poor glycemic control, HbA1c >7%) and Group II (Good glycemic control, HbA1c <7%). Glycated hemoglobin and microalbuminuria were evaluated in all patients. Data was analyzed using SPSS 21.0. P – value of <0.05 was considered as statistically significant. Results: Total of 213 patients were included in the study with male ratio (56.8%) slightly higher than females (43.19%). Mean age of patients was 42.3 ± 2.1 years. Mean glycated hemoglobin in Group I and II was 8.12 ± 0.97% and 5.98 ± 0.41% respectively. In Group I, 57.54% patients were detected with microalbuminuria as compared to Group II (12.26%). P value was statistically significant (<0.001). Conclusion: Microalbuminuria was found more frequently in patients with poor glycemic control. Early detection of urinary microalbumin in these patients may decrease the risk of kidney damage and appropriate and adequate management in initial stage.

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Microalbuminuria in non diabetic population as an marker of nephropathy

Abstract: Our study suggests that microalbuminuria be evaluated as a marker of incipient nephropathy in non-diabetic population with increased metabolic risk.

Cited by 4 publications

References 30 publications

Urinary Peptides Associated Closely with Gestational Diabetes Mellitus

Urinary Peptides Associated Closely with Gestational Diabetes Mellitus

Análisis de laboratorio e interpretación

Microalbuminuria and its association with glycemic control in patients with diabetes mellitus type II.

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