Renal Function and Cognitive Dysfunction: cross-sectional study of users enrolled at Ponte-Family Health Unit

Antunes, Joana; Bulhões, Cláudia; Fonte, Pedro; Abreu, Mafalda Jordão; Oliveira, Rui

doi:10.5935/0101-2800.20150012

Cited by 7 publications

(15 citation statements)

References 33 publications

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“…After adjusting for education and other confounders, the association was attenuated but still statistically significant [11]. Two other studies that adjusted for education suggest that the relationship between GFR and cognitive function may be biphasic, with cognitive dysfunction associated with both a low (GFR < 60 ml/min/1.73 m 2 ) and high GFR (≥ 90 ml/min/1.73 m 2 ) [37, 38]. However, these studies used eGFR rather than mGFR.…”

Section: Discussionmentioning

confidence: 99%

Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study

et al. 2019

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Background Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive function in the healthy general population may reveal early disease mechanisms underlying low-grade impairment of both organs as well as the possibility for intervention. Our aim was to identify an early stage of low-grade impairments in both the brain and the kidneys in the general population. Methods This investigation was a population-based cross-sectional study that included 1627 participants aged 50–62 years who were representative of the general population in the municipality of Tromsø, Norway. The associations between GFR, measured as iohexol clearance, the urinary albumin-creatinine ratio and performance on five tests of cognitive function—the Digit Symbol Substitution Test, the finger tapping test, the Mini-Mental State Examination and the 12-word test parts 1 and 2 – were examined. The data were adjusted for factors known to be associated with both GFR and cognitive function, including cardiovascular risk factors, medications and education level. Results In multivariate adjusted linear regression analyses, we did not observe associations of the measured GFR or albumin-creatinine ratio with performance on any of the five cognitive tests. In an analysis without adjustment for the education level, an association of worse performance on the Digit Symbol Substitution Test with higher measured GFR ( p = 0.03) was observed. An exploratory analysis revealed an inverse relationship between mGFR and a higher education level that remained significant after adjusting for factors known to influence mGFR. Conclusions We did not find evidence of an association between low-grade impairments in either the kidneys or the brain in the middle-aged general population. A possible association between a high GFR and reduced cognitive function should be investigated in future studies. Electronic supplementary material The online version of this article (10.1186/s12882-019-1356-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study

et al. 2019

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“…The second study, in a systematic review design, has the same goal states that there is a possible relationship between anemia and cognitive impairment, especially executive function, and if cognitive impairment has occurred because of anemia, anemia correction must be sought to reach the normal level of hemoglobin. In another study, Antunes et al (2011) in 214 elderly study subjects with renal impairment, the results obtained were around 54.5% anemia research subjects with glomerular filtration rate <60 ml/min/1.73 m 2 compared to research subjects with glomerular filtration rate >90 ml/min/1.73 m 2 with p < 0.001 [21].…”

Section: Discussionmentioning

confidence: 89%

Correlation Between Cognitive Function Impairment and Chronic Kidney Disease With a Low Glomerular Filtration Rate at Sanglah Hospital Denpasar

Laksmidewi

Dewi

Kandarini

2020

Open Access Maced J Med Sci

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BACKGROUND: Chronic kidney disease is a condition of chronic kidney damage with abnormal structure and function of the kidneys that lasts more than 3 months, accompanied or not by a decrease in glomerular filtration rate. Organic kidney disease leaves accumulated organic waste that cannot be removed by the kidneys. Furthermore, several biochemical and metabolic mechanisms such as chronic inflammation and oxidative stress can cause executive disorders. AIM: The aim of the study was to find out an increased risk of impaired cognitive function in patients with chronic kidney disease with a low glomerular filtration rate in Sanglah Hospital. METHOD: This study uses a retrospective case–control analytic observational study design. We included all patients with chronic kidney disease in Sanglah Hospital in December 2017–January 2018. This study involved 46 subjects with chronic kidney disease who met eligibility criteria, classified as a case group with cognitive impairment and a control group without cognitive impairment. RESULTS: Each decrease in glomerular filtration rate < 30 ml/min/173 m2 in patients with chronic renal failure correlates with an increased incidence of cognitive impairment of around 15–25%. The risk of chronic kidney disease patients with glomerular filtration rate < 30 ml/min/1.73 m2 decreased cognitive function 13 times compared to subjects with glomerular filtration rate > 30 ml/min/ 1.73 m2. CONCLUSION: Low glomerular filtration rate correlate with increased risk of cognitive impairment.

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“…The design of 15 studies was a prospective cohort design, and these studies sought to evaluate changes in cognitive function over time in patients with CKD [12,25,34,36,39,41,46,47,49,50,54,[59][60][61][62]66]. The comparative crosssectional studies compared patients with CKD with another patient group, and this method was utilized in 15 studies [33,35,37,40,[42][43][44]48,[51][52][53]55,56,63,64]. Of these studies, 12 utilized patients with a GFR greater than 60ml/min/1.73m 2 as a comparison group [33,35,40,43,44,48,[51][52][53]55,63,64], one study utilized patients on hemodialysis (HD) as a comparison group [56], and one study utilized both patients with a GFR greater than 60ml/min/1.73m 2 and patients on renal replacement therapy (HD, peritoneal dialysis, and transplant) as a comparison group…”

Section: Methodsmentioning

confidence: 99%

“…The comparative crosssectional studies compared patients with CKD with another patient group, and this method was utilized in 15 studies [33,35,37,40,[42][43][44]48,[51][52][53]55,56,63,64]. Of these studies, 12 utilized patients with a GFR greater than 60ml/min/1.73m 2 as a comparison group [33,35,40,43,44,48,[51][52][53]55,63,64], one study utilized patients on hemodialysis (HD) as a comparison group [56], and one study utilized both patients with a GFR greater than 60ml/min/1.73m 2 and patients on renal replacement therapy (HD, peritoneal dialysis, and transplant) as a comparison group [42]. Of the remaining studies, one study utilized a crosssectional design without a comparison group [58], one study utilized a case report [65], one study utilized a retrospective comparative study [57], one study conducted a post hoc analysis of a randomized controlled trial [38], and one study utilized a population based observational survey [45].…”

Section: Methodsmentioning

confidence: 99%

The assessment of cognitive function in older adult patients with chronic kidney disease: an integrative review

et al. 2018

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The assessment of cognitive function in older adults with CKD with standardized tests is completed in various ways. Unfortunately, the common methods of assessment of cognitive function may not be fully examining the domains of impairment commonly found in older adults with CKD. Further research is needed to identify the ideal cognitive test to best assess older adults with CKD for cognitive impairment.

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Renal Function and Cognitive Dysfunction: cross-sectional study of users enrolled at Ponte-Family Health Unit

Cited by 7 publications

References 33 publications

Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study

Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study

Correlation Between Cognitive Function Impairment and Chronic Kidney Disease With a Low Glomerular Filtration Rate at Sanglah Hospital Denpasar

The assessment of cognitive function in older adult patients with chronic kidney disease: an integrative review

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