Risk assessment score in pre-kidney transplantation: methodology and the socioeconomic characteristics importance

Gusukuma, L.; Silva, Helio Tedesco; Pestana, José Osmar Medina

doi:10.5935/0101-2800.20140049

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…This study has the limitation of being a single-center retrospective study in a relatively small cohort of 5,359 kidney transplants and with a limited number of factors that could be analyzed. In addition, some important factors could not be included, as the PRA (panel reactive antibody) because different methodologies for antibody determination have been used during the period covered by this study, socioeconomic variables, which are especially relevant in developing countries (43,44) and cardiovascular disease, a very important risk factor for patient survival (42,45).…”

Section: Discussionmentioning

confidence: 99%

Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes

et al. 2020

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As the availability of kidneys for transplantation continues to be outpaced by its growing demand, there has been an increasing utilization of older deceased donors in the last decades. Considering that definition of factors that influence deceased donor kidney transplant outcomes is important for allocation policies, as well as for individualization of post-transplant care, the purpose of this study was determine the risks for death censored graft survival and for patient survival conferred by older age of the donor in the context of the age of the recipient and of risk factors for graft and/or patient survival. The investigation was conducted in a single-center cohort of 5,359 consecutive first kidney transplants with adult deceased donors performed on non-prioritized adult recipients from January 1, 2002, to December 31, 2017. Death censored graft survival and patient survival were lower in older donors, whereas graft survival was higher and patient survival was lower in old recipients. The analyses of combinations of donor and recipient ages showed that death censored graft survival was lower in younger recipients in transplants from 18 to 59-year old donors, with standard or extended criteria, but no difference in graft survival was observed between younger and older recipients when the donor was ≥ 60-year old. Patient survival was higher in younger recipients in transplants with younger or older donors. Two to six HLA-A,B,DR mismatches, when compared to 0-1 MM, conferred risk for death-censored graft survival only in transplants from younger donors to younger recipients. Pre-transplant diabetes conferred risk for patient survival only in 50-59-year old recipients, irrespectively, of the age of the donor. Time on dialysis ≥ 10 years was a risk factor for patient survival in transplants with all donor-recipient age combinations, except in recipients with ≥ 60 years that received a kidney from an 18-49-year old donor. In conclusion, the results obtained in this study underline the importance of analyzing the impact of the age of the donor taking into consideration different scenarios.

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Section: Discussionmentioning

confidence: 99%

Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes

et al. 2020

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“…The greatest originality of the present study lies in describing in detail the results of KT in patients with HIV infection in two cohorts of different levels of socio‐economic and cultural development. Indeed, a growing body of evidence suggests the impact of socio‐economic and quality of life‐related variables on the results of KT …”

Section: Discussionmentioning

confidence: 99%

Regional differences in the management and outcome of kidney transplantation in patients with human immunodeficiency virus infection: A 3‐year retrospective cohort study

Cristelli

Cofan

Tedesco‐Silva

et al. 2017

Transplant Infectious Dis

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“… 5 Socioeconomic variables have always influenced health-related outcomes. 3 In a previous study, four of ten variables influencing transplant outcomes were socioeconomic, perhaps explaining the apparent discrepancy in the cause of death between developed and developing countries. 3 …”

Section: Introductionmentioning

confidence: 92%

“…A previous study revealed several risk factors associated with death within the first 6 months after transplantation, including donor age and cause of death, recipient gender, HLA compatibility, changes in electrocardiogram, weight at the time of transplantation, financial assistance, monthly income, and having children and family support. 3 Patients living in lower socioeconomic areas have a higher risk of death 2 and patients with lower income presented an additional 36.2% risk for graft loss. 4 In the past, evaluating the impact of socioeconomic factors on the outcome of transplantation was difficult, so race was used as a surrogate for patient's socioeconomic status.…”

Section: Introductionmentioning

confidence: 99%

The influence of clinical, environmental, and socioeconomic factors on five-year patient survival after kidney transplantation

et al. 2018

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Risk assessment score in pre-kidney transplantation: methodology and the socioeconomic characteristics importance

Cited by 6 publications

References 37 publications

Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes

Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes

Regional differences in the management and outcome of kidney transplantation in patients with human immunodeficiency virus infection: A 3‐year retrospective cohort study

The influence of clinical, environmental, and socioeconomic factors on five-year patient survival after kidney transplantation

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