Vasculopathy in the kidney allograft at time of transplantation delays recovery of graft function after deceased-donor kidney transplantation

Marques, Inara; Repizo, Liliany Pinhel; Pontelli, Renato; Paula, Flávio Jota de; Nahas, William Carlos; David, Débora Leite; Neto, Elias David; Lemos, Francisco José Alves

doi:10.5935/0101-2800.20140010

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…1,2 Although 30-day outcomes are generally used as primary outcomes for surgical complications, this time point may not accurately reflect the actual incidence of EGL. DGF may extend beyond 30 days, [14][15][16] and a Figure 2 | Landmark analysis showing the short-term and long-term patient survival rates. Reference population: recipients without early graft loss after the first kidney transplant procedure.…”

Section: Discussionmentioning

confidence: 99%

A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss

Kok

Schaapherder

Mensink

et al. 2020

Kidney International

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Section: Discussionmentioning

confidence: 99%

A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss

Kok

Schaapherder

Mensink

et al. 2020

Kidney International

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Delayed Graft Function Duration in Deceased Donor Kidney Transplants

Leão-Reis¹,

Silva²,

Morais³

et al. 2022

Transplantation Proceedings

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Phosphocalcic Markers and Calcification Propensity for Assessment of Interstitial Fibrosis and Vascular Lesions in Kidney Allograft Recipients

et al. 2016

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Renal interstitial fibrosis and arterial lesions predict loss of function in chronic kidney disease. Noninvasive estimation of interstitial fibrosis and vascular lesions is currently not available. The aim of the study was to determine whether phosphocalcic markers are associated with, and can predict, renal chronic histological changes. We included 129 kidney allograft recipients with an available transplant biopsy in a retrospective study. We analyzed the associations and predictive values of phosphocalcic markers and serum calcification propensity (T50) for chronic histological changes (interstitial fibrosis and vascular lesions). PTH, T50 and vitamin D levels were independently associated to interstitial fibrosis. PTH elevation was associated with increasing interstitial fibrosis severity (r = 0.29, p = 0.001), while T50 and vitamin D were protective (r = -0.20, p = 0.025 and r = -0.23, p = 0.009 respectively). On the contrary, fibroblast growth factor 23 (FGF23) and Klotho correlated only modestly with interstitial fibrosis (p = 0.045) whereas calcium and phosphate did not. PTH, vitamin D and T50 were predictors of extensive fibrosis (AUC: 0.73, 0.72 and 0.68 respectively), but did not add to renal function prediction. PTH, FGF23 and T50 were modestly predictive of low fibrosis (AUC: 0.63, 0.63 and 0.61) but did not add to renal function prediction. T50 decreased with increasing arterial lesions (r = -0.21, p = 0.038). The discriminative performance of T50 in predicting significant vascular lesions was modest (AUC 0.61). In summary, we demonstrated that PTH, vitamin D and T50 are associated to interstitial fibrosis and vascular lesions in kidney allograft recipients independently of renal function. Despite these associations, mineral metabolism indices do not show superiority or additive value to fibrosis prediction by eGFR and proteinuria in kidney allograft recipients, except for vascular lesions where T50 could be of relevance.

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Vasculopathy in the kidney allograft at time of transplantation delays recovery of graft function after deceased-donor kidney transplantation

Abstract: The presence of vasculopathy in the kidney allograft at time of transplantation was identified as an important factor independently associated with prolonged DGF. Prolonged DGF negatively impacts 1-year graft function.

Cited by 3 publications

References 22 publications

A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss

A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss

Delayed Graft Function Duration in Deceased Donor Kidney Transplants

Phosphocalcic Markers and Calcification Propensity for Assessment of Interstitial Fibrosis and Vascular Lesions in Kidney Allograft Recipients

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