The Role of Nanomaterials in Cosmetics: National and International Legislative Aspects

Melo, Adriana de; Amadeu, Marcela Seragiotto; Lancellotti, Marcelo; Hollanda, Luciana Maria de; Machado, Daisy

doi:10.5935/0100-4042.20150042

Cited by 19 publications

(17 citation statements)

References 1 publication

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“…Considering the social impact of skin care on life quality (and on financial context), it is not surprising that cosmetic industries such as Lancôme, Christian Dior, Estee Lauder, Shiseido, Johnsons & Johnsons, and many others are investing in the engineered nanomaterials for makeup products and alternative formulations for the management of different dermatological diseases [41,42]. Although an evident and increasing incorporation of nanotechnology in most of their manufacturing processes, the scaling-up to achieve greater production is the major difficulty faced by industries, limiting them to the use of conventional techniques, e.g., the patented "Gaulin method" of Johnson & Johnson Company exploits a high shear homogenizer equipment, working at high pressure and temperature, for the production of liposomes for cosmetic/diagnostic/pharmaceutical applications [43].…”

Section: Manufacturing Issuesmentioning

confidence: 99%

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Bochicchio¹,

Dalmoro

Simone

et al. 2020

Cosmetics

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Novel nanotechnologies represent the most attractive and innovative tools to date exploited by cosmetic companies to improve the effectiveness of their formulations. In this context, nanoliposomes have had a great impact in topical preparations and dermocosmetics, allowing the transcutaneous penetration and absorption of several active ingredients and improving the stability of sensitive molecules. Despite the recent boom of this class of delivery systems, their industrial production is still limited by the lack of easily scalable production techniques. In this work, nanoliposomes for the topical administration of vitamin D3, K2, E, and curcumin, molecules with high antioxidant and skin curative properties but unstable and poorly absorbable, were produced through a novel simil-microfluidic technique. The developed high-yield semi continuous method is proposed as an alternative to face the problems linked with low productive conventional methods in order to produce antioxidant formulations with improved features. The novel technique has allowed to obtain a massive production of stable antioxidant vesicles of an 84–145 nm size range, negatively charged, and characterized by high loads and encapsulation efficiencies. The obtained products as well as the developed high-performance technology make the achieved formulations very interesting for potential topical applications in the cosmetics/cosmeceutical field.

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Section: Manufacturing Issuesmentioning

confidence: 99%

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Bochicchio¹,

Dalmoro

Simone

et al. 2020

Cosmetics

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“…The very changes in biological, chemical and other properties that can make nanotechnology applications so exciting, however, also may merit examination to determine any effects on product safety, effectiveness or other attributes. 12 The application of nanotechnology may result in product attributes that differ from those of conventionallymanufactured products and thus evaluations of safety or effectiveness of FDA-regulated products that include nanomaterials or otherwise involve the application of nanotechnology should consider the unique properties and behaviors that nanomaterials may exhibit. However, FDA does not categorically judge all products containing nanomaterials or otherwise involving the application of nanotechnology as intrinsically benign or harmful.…”

Section: Us Food and Drug Administration (Fda) And Abbreviated New Drmentioning

confidence: 99%

“…FDA encourages industry to consult early with the agency to address questions related to the regulatory status or to the safety, effectiveness or other attributes of products that contain nanomaterials or otherwise involve application of nanotechnology. [11][12][13][14] These early consultations afford an opportunity to clarify the methodologies and data that will be needed to meet the sponsor's obligations.…”

Section: Industry Remains Responsible For Ensuring That Its Products mentioning

confidence: 99%

Ethical and Administrative Implications of Nanoscale Technology for Efficient and Safe Delivery of Drugs: Analytical and Regulatory Aspects

Tiwari¹,

Tiwari²,

Wal³

2019

IJPER

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Background: Cutting-edge issues for nanomedicine involve knowledge of the problems associated with toxicity and environmental effect of nanoscale substances (substances whose structure is on the dimensions of nanometers, i.e. billionths of a meter). Nanoparticles are able to reach inner biomolecules, which is not possible for larger debris. Materials and Methods: The nanosuspension turned into analytically characterized and subjected to regulatory aspects. Scientific facts used to make regulatory decisions about merchandise starting from cosmetics to chemotherapy agents to food packaging, FDA has lengthy encountered the combination of promise, threat and uncertainty that accompanies emerging technologies. Nanotechnology is not specific on this regard. Present article covered about regulatory aspects of Abbreviated New Drug Application (ANDA) and Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Conclusion: The objective of this review is to know about the FDA regulations towards nanotechnology and various techniques used to analyze this tiny technology for drug delivery.

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“…In cosmetic product development, nano-ingredients find a place in products with anti-aging effects, improved penetration deep into the skin layers, thereby enhancing the therapeutic effects of the drug moiety and for products offering photoprotection [21]. The so-called "nano-cosmetics" are thus the cosmetic formulations that include actives (nanosized) or other nanostructured ingredients with superior performance in comparison to the conventional products [22]. Diverse nanomaterials are already in use in the currently marketed cosmetic products, including nanoemulsions, lipid nanoparticles, nanovesicles and mineral nanoparticles namely silver, calcium fluoride, titanium dioxide, alumina, zinc oxide, silicon dioxide and copper [21].…”

Section: Nanomaterials In Cosmeticsmentioning

confidence: 99%

“…Apart from nanocarriers, the actives like avobenzone, retinol/ isotreti-noin etc. have been successfully employed as nanosized ingredients in a variety of cosmetic products including anti-wrinkle creams, shampoos, anti-cellulite creams, moisturizers, fairness creams, aftershave lotions, deodorants, sunscreens, nail polishes and sunscreens [22]. Other examples of nanocosmetic products include eye liner, bronzer, body firming lotion, exfoliant scrub and styling gel.…”

Section: Nanomaterials In Cosmeticsmentioning

confidence: 99%

Regulatory Concerns for Nanomaterials in Sunscreen Formulations

Pathak

Pattnaik

Porwal

2018

ACCTRA

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Background: There has been a phenomenal rise in the nanomaterial-based cosmetic formulations in the market, raising serious concerns over the possible biological impact on humans, animals and the environment as a whole. However, scarce reports can be found on the safety assessment of nanomaterials incorporated in cosmetic formulations including sunscreens. Hence, uncertainties loom for their safe use in cosmetics including those applied dermatologically. Unfortunately, not much research has been devoted to assess the safety profile of nanomaterials in cosmetics and the possible health hazards. As a large number of nanotechnological sunscreen products containing diverse sun filters against UV exposure are penetrating the market, the importance of adequate assessment of nanomaterial exposure, its toxicokinetics including biodistribution, and other health risks is now widely recognized. Objective: The write up presents an overview of the nanomaterials used in sunscreen products and discusses the various laws and regulations in force in various countries. The review focuses on the current safety and regulation of nanomaterials in sunscreens. Conclusion: While many countries have their own set of regulatory guidelines, it is high time to have a globally acceptable guideline framework to protect both the consumers and manufacturers for safe use, manufacture and sale of nanotechnology-based cosmetics. Harmonization across the globe is desirable.

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The Role of Nanomaterials in Cosmetics: National and International Legislative Aspects

Cited by 19 publications

References 1 publication

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

Ethical and Administrative Implications of Nanoscale Technology for Efficient and Safe Delivery of Drugs: Analytical and Regulatory Aspects

Regulatory Concerns for Nanomaterials in Sunscreen Formulations

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