<i>IN VITRO</i>ANTIBACTERIAL ACTIVITY AND TOXICITY TOWARD<i>Artemia salina</i>Leach. OF SOME TRIAZENE COMPOUNDS

Paraginski, Gustavo Luiz; Berticelli, Claiton Roberto; Zambiazi, Priscilla J.; Paraginski, Vanessa Teixeira Kunz; Hörner, Manfredo; Santos, Aline Joana Rolina Wohlmuth Alves dos; Hörner, Rosmari

doi:10.5935/0100-4042.20140180

Cited by 3 publications

(11 citation statements)

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“…However, more studies regarding statins structure are needed in order to ellucidate their effect against bacteria (Graziano et al, 2015). Regarding TZC, several studies using these compounds have shown that they have antimicrobial activity (Hörner et al, 2008;Domingues et al, 2010;Ombaka, Muguna, Gichumbi, 2012;Mohammadi, 2014;Paraginski et al, 2014;Tizotti et al, 2016), being proposed that their action mechanism occurs due to the chelating activity to metallic ions from the bacterial cell wall, inhibiting stages of bacterial synthesis, leading to cell death (Hörner et al, 2008;Ombaka, Muguna, Gichumbi, 2012;Yeo et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…TZC complexed with palladium(II) showed better activity against the strains tested when compared to free ligands and precursor, proving to be an alternative for a new class of drugs with antibacterial activity. This activity can be justified since TZC complexed with transition metals such as Pd(II) can interact and cause damage to the DNA, providing a potent antibacterial activity, in addition to blocking cancer cells division leading to cell death (Hecht, 2000;Song et al, 2006;Paraginski et al, 2014). Therefore, complementary studies must be performed for the assessment of other biological parameters, their toxicity and therapeutic efficacy (Nunes et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)}

Rampelotto

Lorenzoni

Silva

et al. 2018

Braz. J. Pharm. Sci.

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The treatment of infections caused by resistant microorganisms represents a big challenge in healthcare due to limited treatment options. For this reason, the discovery of new active substances which are able to perform innovative and selective actions is of great impact nowadays. Statins and triazenes (TZC) have consolidated as a promising class of compounds, characterized by the expressive biological activity, especially antimicrobial activities. The aim of this study was to assess the in vitro synergistic antibacterial effect of the association of statins and a new TZC complex {[1-(4-bromophenyl)-3-phenyltriazene N 3oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4)palladium(II)} (Pd(DMBA)LBr) against American Type Culture Collection (ATCC) strains and clinical isolates. The complex and the statins showed bacterial activity of all tested strains and clinical isolates, evidencing that TZC complexion with metals can be promising. Simvastatin showed synergy when associated to the complex (FICI≤0.5), being the minimum inhibitory concentration (MIC) of 16 µg mL-1 found in 6 samples. Thus, it is possible to infer that the association between Pd(DMBA)LBr and simvastatin consists of an alternative to increase the pontential of these compounds, since statins have low toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)}

Rampelotto

Lorenzoni

Silva

et al. 2018

Braz. J. Pharm. Sci.

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“…Hörner et al 35 reported the in vitro antibacterial activities of newly synthesized diaryltriazenes against standard bacteria (American Type Culture Collection, ATCC) and clinical isolates including multidrug-resistant (MDR) bacteria, and acute toxicity against Artemia salina . Initial experiments showed that these triazene compounds have biological activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis strains, with MIC values of 0.02 and 0.03 mg/mL, respectively 27 , 36 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of the biological potential of diaryltriazene-derived triazene compounds

Figueiredo

Filho

Sodré

et al. 2021

Sci Rep

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In the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3-bis(X-methoxy-Y-nitrophenyl)triazenes [X = 2 and 5; Y = 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the effective MIC of 9.937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the first to report promising activities of triazene compounds against yeast and filamentous fungi. The results showed the potential utility of triazenes as agents affecting selected resistant bacterial and fungal strains.

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“…Several studies using TZC compounds have shown that these compounds have broad antimicrobial activity (Hörner et al 2008;Domingues et al, 2010;Ombaka et al, 2012;Paraginski et al, 2014;Tizotti et al, 2016). Studies suggest that the antibacterial action of TZCs is due to the chelating activity of metal ions that are constituents of the bacteria cell wall, hindering their synthesis and leading to cell death (Hörner et al 2008;Ombaka et al, 2012).…”

Section: Biological Activitymentioning

confidence: 99%

“…Studies suggest that the antibacterial action of TZCs is due to the chelating activity of metal ions that are constituents of the bacteria cell wall, hindering their synthesis and leading to cell death (Hörner et al 2008;Ombaka et al, 2012). According to Paraginski and colleagues, complexation of TZC compounds with metal ions such as gold (I) can provide potent antibacterial activity (Paraginski et al, 2014). However, this is, to the best of our knowledge, the first study to use such compounds complexed with metals like gold against biofilm-producing microorganisms isolated from platelet concentrates.…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis, characterization and biological activity of a gold(I) triazenide complex against chronic myeloid leukemia cells and biofilm producing microorganisms

Nunes

Garzon

Rampelotto

et al. 2018

Braz. J. Pharm. Sci.

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The enhancement of anti-leukemia therapy and the treatment of infections caused by multidrug-resistant pathogens are major challenges in healthcare. Although a large arsenal of drugs is available, many of these become ineffective, and as a result, the discovery of new active substances occurs. Notably, triazenes (TZCs) have been consolidated as a promising class of compounds, characterized by significant biological activity, especially antiproliferative and antimicrobial properties. The aim of this study is the synthesis and characterization of a new triazenide complex of gold (I), as well as the in vitro assessment of its antiproliferative activity against the K562 cell line (Chronic Myeloid Leukemia), and antibacterial activity against bacterial isolates of biofilm-producing coagulase-negative staphylococci. The combination of TZC with gold metal tends to have a synergistic effect against all biofilm-producing isolates, with Minimum Inhibitory Concentration values (MIC) between 32 and 64 µg mL-1. It has also shown activity against K562 cell line, getting an IC 50 =4.96 µM. Imatinib mesylate (Glivec) was used as reference, with IC 50 =3.86 µM. To the best of our knowledge, this study represents the first report of the activity of a TZC complexed with gold ion in the oxidation state (I) against microorganisms that produce biofilm and K562 cells.

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IN VITROANTIBACTERIAL ACTIVITY AND TOXICITY TOWARDArtemia salinaLeach. OF SOME TRIAZENE COMPOUNDS

Cited by 3 publications

References 0 publications

Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)}

Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)}

Assessment of the biological potential of diaryltriazene-derived triazene compounds

Synthesis, characterization and biological activity of a gold(I) triazenide complex against chronic myeloid leukemia cells and biofilm producing microorganisms

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