2018
DOI: 10.1590/s2175-97902018000217369
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Abstract: The treatment of infections caused by resistant microorganisms represents a big challenge in healthcare due to limited treatment options. For this reason, the discovery of new active substances which are able to perform innovative and selective actions is of great impact nowadays. Statins and triazenes (TZC) have consolidated as a promising class of compounds, characterized by the expressive biological activity, especially antimicrobial activities. The aim of this study was to assess the in vitro synergistic a… Show more

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Cited by 10 publications
(8 citation statements)
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“…An in vitro study evaluated the bacterial activity of statins against different strains of the American Type Culture Collection (ATCC) and ten cultures of clinical isolates. As reported in other investigations, this study showed a greater sensitivity of Gram-positive bacteria to the action of statins, with the highlight being the activity of atorvastatin and, above all, simvastatin [8].…”
Section: Resultssupporting
confidence: 87%
“…An in vitro study evaluated the bacterial activity of statins against different strains of the American Type Culture Collection (ATCC) and ten cultures of clinical isolates. As reported in other investigations, this study showed a greater sensitivity of Gram-positive bacteria to the action of statins, with the highlight being the activity of atorvastatin and, above all, simvastatin [8].…”
Section: Resultssupporting
confidence: 87%
“…2018; Rampelotto et al . 2018). In the present study, we only detected synergistic interactions when rosuvastatin was added to levofloxacin using a checkerboard test.…”
Section: Discussionmentioning
confidence: 99%
“…Studies reporting the importance of drug repositioning for the treatment of infectious diseases are available, and among them we cite several classes, such as antidepressants (Bottega et al 2020;da Rosa et al , 2021Foletto et al 2020Foletto et al , 2021Machado et al 2020;Serafin et al 2020), antihypertensive (Hu et al 2018), antihistamines (Bruer et al 2019;El-Nakeeb et al 2011), anti-inflammatory (Chan et al 2017), alcohol-aversive agentes (Serafin et al 2020), benzodiazepines (da Rosa et al 2021, and statins (Rampelotto et al 2018). In this commentary, the class of proton pump inhibitors (PPIs) is emphasized.…”
Section: Commentarymentioning
confidence: 99%