CHEMICAL STUDY AND ANTIPROLIFERATIVE, TRYPANOCIDAL AND LEISHMANICIDAL ACTIVITIES OF<i>Maxillaria picta</i>

Almeida, Thiago L. de; Monteiro, Josiane A.; Lopes, Greice K.P.; Chiavelli, Lucas Ulisses Rovigatti; Santin, Silvana Maria de Oliveira; Silva, Cleuza C. da; Kaplum, Vanessa; Scariot, Débora B.; Nakamura, Celso V.; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Faria, Ricardo Tadeu de; Pomini, Armando M.

doi:10.5935/0100-4042.20140179

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 1 H NMR signals were diagnostic for sterols with a 14α-methyl and 8(9)- and 24(28)-diene structure [45]. Analysis of the 13 C NMR spectral data for the C31:2 isolated sterol showed signals in agreement with those for a 24-methylenelanost-8-en-3β-ol and were in agreement with shifts reported for eburicol in the literature (Scheme 2) [45,46,47].…”

Section: Resultssupporting

confidence: 78%

Steroids from Marine-Derived Fungi: Evaluation of Antiproliferative and Antimicrobial Activities of Eburicol

et al. 2019

View full text Add to dashboard Cite

The most common sterol in fungi is ergosterol, which has frequently been investigated in human pathogenic fungal strains. This sterol, and others isolated from fungal strains, has also demonstrated cytotoxicity against cancer cell lines and antimicrobial activities. Marine fungi can produce high amounts of bioactive compounds. So, a screening was performed to study sterol composition using GC/MS in 19 marine fungal strains and ergosterol was always the major one. One strain, Clonostachys rosea MMS1090, was selected due to its high amount of eburicol and a one strain many compounds approach was performed on seven culture media to optimize its production. After purification and structural identification by NMR, eburicol was assessed against four cancer cell lines, MCF-7, MDA-MB-231, NSCLC-N6-L16 and A549, and seven human pathogenic bacteria Staphylococcus aureus, Bacillus sp., Bacillus cereus, Listeria ivanovii, Escherichia coli, Citrobacter freundii and Salmonella spp. The most significant activity was cytotoxicity against MCF-7 cells (2 µM). This is the first report of such an accumulation of eburicol in the marine fungal strain C. rosea confirming its potential in the production of bioactive lipids.

show abstract

Section: Resultssupporting

confidence: 78%

Steroids from Marine-Derived Fungi: Evaluation of Antiproliferative and Antimicrobial Activities of Eburicol

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Our results made evident that the fruit essential oil from G. integrifolia had moderate cytotoxic activity against human tumor cell lines, but no cytotoxic activity against porcine non-tumor cells. The SI of the fruit essential oilwhich is the relation between GI 50 value of non-tumor cells divided by tumor cells (Almeida et al 2014)was over 6.06. Thus, this essential oil is more active in tumor cells than in non-tumor cells and, therefore, more selective and appropriate for the use against neoplastic cells.…”

Section: Resultsmentioning

confidence: 97%

Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil

Bortolucci

Raimundo

Fernandez

et al. 2021

Natural Product Research

View full text Add to dashboard Cite

The chemical composition of Gallesia integrifolia fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine). Antiinflammatory activity that provides 50% inhibition of nitric oxide production (55 mg/mL) of essential oil of the fruits. It also presents cytotoxic activity against MCF-7 (GI 50 ¼ 66 mg/mL), NCI-H-460 (GI 50 ¼ 147 mg/mL), HeLa (GI 50 ¼ 182 mg/mL) and HepG2 (GI 50 ¼ 240 mg/mL). The essential oil is more active in tumor cells than in non-tumor cells and the GI 50 values for essential oil reported in our work support future studies.

show abstract

Screening of six medicinal plant species for antileishmanial activity

et al. 2020

View full text Add to dashboard Cite

This study is aimed to investigate the in vitro anti-leishmanial activity of ethanolic, aqueous or dichloromethane extracts of leaves, flowers, fruits or roots, of six medicinal plant species, namely, Nectandra megapotamica, Brunfelsia uniflora, Myrcianthes pungens, Anona muricata, Hymenaea stigonocarpa and Piper corcovandesis. After isolation and analysis of chemical components by ultra-high performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), the extracts were also tested for toxicity in J774.A1 macrophages and human erythrocytes. Phenolic acids, flavonoids, acetogenins, alkaloids and lignans were identified in these extracts. Grow inhibition of promastigotes forms of Leishmania amazonensis and Leishmania braziliensis and the cytotoxicity in J774.A1 macrophages were estimated by the XTT method. The most promising results for L. amazonensis and L. braziliensis were shown by the ethanolic extract of the fruits of Hymenaea stigonocarpa and dichloromethane extract of the roots of Piper corcovadensis, with IC50 of 160 and 150 μg mL−1, resp. Ethanolic extracts of A. muricata (leaf), B. uniflora (flower and leaf), M. pungens (fruit and leaf), N. megapotamica (leaf), and aqueous extract of H. stigonocarpa (fruit) showed IC50 > 170 μg mL−1 for L. amazonensis and > 200 μg mL−1 for L. braziliensis. The extracts exhibited low cytotoxicity towards J774.A1 macrophages with CC50 > 1000 μg mL−1 and hemolytic activity from 0 to 46.1 %.

show abstract

CHEMICAL STUDY AND ANTIPROLIFERATIVE, TRYPANOCIDAL AND LEISHMANICIDAL ACTIVITIES OFMaxillaria picta

Cited by 4 publications

References 0 publications

Steroids from Marine-Derived Fungi: Evaluation of Antiproliferative and Antimicrobial Activities of Eburicol

Steroids from Marine-Derived Fungi: Evaluation of Antiproliferative and Antimicrobial Activities of Eburicol

Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil

Screening of six medicinal plant species for antileishmanial activity

Contact Info

Product

Resources

About