TRANSDERMAL FORMULATIONS CONTAINING HUMAN SEXUAL STEROIDS: DEVELOPMENT AND VALIDATION OF METHODS AND<i>IN VITRO</i>DRUG RELEASE

Polonini, Hudson; Soldati, P.; Augusto, Marcone; Oliveira, Leal de; Chaves, Graças M.; Raposo, Nádia Rezende Barbosa; José, Rua; Kelmer, Lourenço

doi:10.5935/0100-4042.20140116

Cited by 10 publications

(2 citation statements)

References 12 publications

(19 reference statements)

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“…The transdermal semi-solid vehicle should enable that incorporated drugs can reach the systemic circulation. Therefore, they often contain liposomes that assist in the transdermal delivery of the drug [24]. One such vehicle is Pentravan ® , manufactured by Fragon (USA), an oil-in-water (o/w) emulsion base.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Effect of Structural Modification of Ibuprofen on the Penetration of Ibuprofen from Pentravan® (Semisolid) Formulation Using Human Skin and a Transdermal Diffusion Test Model

Ossowicz-Rupniewska,

Nowak,

Klebeko

et al. 2021

Materials

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The effect of transdermal vehicle (Pentravan®) on skin permeability was examined for unmodified ibuprofen (IBU) and ion pairs of ibuprofen with new L-valine alkyl esters [ValOR][IBU]. The percutaneous permeation across the human skin and transdermal diffusion test model (Strat-M® membranes) of ibuprofen and its structural modification were measured and compared using Franz diffusion cells. For comparison, the penetration of ibuprofen from a commercial product was also investigated. The cumulative amount of drug permeated through human skin at the end of the 24 h study was highest for ibuprofen derivatives containing propyl (C3), isopropyl (C3), ethyl (C2), and butyl (C4) esters. For Strat-M®, the best results were obtained with the alkyl chain length of the ester from C2 to C5. The permeation profiles and parameters were appointed, such as steady-state flux, lag time, and permeability coefficient. It has been shown that L-valine alkyl ester ibuprofenates, with the propyl, butyl, and amyl chain, exhibit a higher permeation rate than ibuprofen. The diffusion parameters of analyzed drugs through human skin and Strat-M® were similar and with good correlation. The resulting Pentravan-based creams with ibuprofen in the form of an ionic pair represent a potential alternative to other forms of the drug-containing analgesics administered transdermally. Furthermore, the Strat-M® membranes can be used to assess the permeation of transdermal preparations containing anti-inflammatory drugs.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Effect of Structural Modification of Ibuprofen on the Penetration of Ibuprofen from Pentravan® (Semisolid) Formulation Using Human Skin and a Transdermal Diffusion Test Model

Ossowicz-Rupniewska,

Nowak,

Klebeko

et al. 2021

Materials

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“…Some steroids, such as progesterone as shown in Figure-2, act like sex hormones, responsible for sexual characteristics and supports for reproduction [42][43][44]. Steroids analyses in different matrices have been possible through analytical separation techniques such as liquid chromatography (HPLC) [45,46], capillary zone electrophoresis (CZE) [47], micellar electrokinetic chromatography (MEKC) [48], and capillary electrochromatography (CEC) [49,50]. A separation technique in liquid medium that has gained significant interest in recent years is the CEC, which combines some characteristics of both HPLC and capillary electrophoresis (CE) [51].…”

mentioning

confidence: 99%

Spectrophotometric determination of progesterone and dopamine in breast cancer serum

2019

University of Thi-Qar Journal

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Dopamine (DA) is one of the most important catecholamine neurotransmitters in the human central nervous system in the brain and plays a key role in the functioning of the renal, hormonal, and cardiovascular systems. Abnormal release of DA will contribute to some diseases such as Alzheimer's and Parkinson's disease. Therefore, the sensitive determination of DA becomes increasingly significant in the field of clinical disease diagnosis and the research of physiological functions. Progesterone is an essential for the development and cyclical regulation of hormone responsive tissues including the breast and reproductive tract. In the breast, progesterone acts in concert with estrogen to promote proliferative and pro-survival gene programs. Progesterone has actions in breast cancer. This paper shows a spectrophotometric method for determination dopamine and progesterone concentration in serum samples, fifty six veins blood samples collected from healthy control and breast cancer patient groups. The analytical data obtained by using UV-Spectrophotometer ( max = 250, 266 nm), linearity (0.5-2.0, 0.25-1.5 ng/ml) for dopamine, progesterone respectively. The molar absorptivity (), correlation coefficient (R 2) and limit of detection (LOD) for dopamine, progesterone ( =2.5156  10 6 , 4.1935 10 6 L.mol-1 cm-1), (R 2 = 0.9979, 0.99957) and (0.64, 0.57 ng/ml) respectively. The results show significant differences between the concentrations of dopamine and progesterone in control and breast cancer patient groups (p0.05).It is fast, sensitive, selective and reliable quantification spectrophotometric method used in complex biological samples.

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A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage

et al. 2017

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Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Across the solar radiation spectrum, UV light is the main cause behind skin problems. In the search for novel photoprotective compounds, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All title compounds were investigated for their UV filtering, antioxidant, antifungal, and antiproliferative activities. For the photoprotection assays we used a diffuse transmittance technique to determine the sun protection factor (SPF) in vitro, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) tests for evaluating the antioxidant activity of the more potent compounds. Among them, 8-(2,5-dihydroxyphenyl)-7H-purin-6-ol (compound 26) proved to be a good radical scavenger and is also endowed with broad-spectrum UVA filtering capabilities, suitable for further development as a protective molecule.

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TRANSDERMAL FORMULATIONS CONTAINING HUMAN SEXUAL STEROIDS: DEVELOPMENT AND VALIDATION OF METHODS ANDIN VITRODRUG RELEASE

Cited by 10 publications

References 12 publications

Assessment of the Effect of Structural Modification of Ibuprofen on the Penetration of Ibuprofen from Pentravan® (Semisolid) Formulation Using Human Skin and a Transdermal Diffusion Test Model

Assessment of the Effect of Structural Modification of Ibuprofen on the Penetration of Ibuprofen from Pentravan® (Semisolid) Formulation Using Human Skin and a Transdermal Diffusion Test Model

Spectrophotometric determination of progesterone and dopamine in breast cancer serum

A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage

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