Structural alterations of the choroid evaluated using enhanced depth imaging optical coherence tomography in patients with coronavirus disease

Kocamış, Özkan; Temel, Emine; Hızmalı, Lokman; Aşıkgarip, Nazife; Örnek, Kemal; Sezgin, Fikriye Milletli

doi:10.5935/0004-2749.20220066

Cited by 3 publications

(5 citation statements)

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“…They stated that these results were associated with vascular damage, hypercoagulability, and hyperinflammation factors causing ischemia in the choriocapillaris, leading to a decrease in CVI. The authors state that the results at four months after remission are close to the measurements of the control group [34] . A study comparing the group with mild COVID-19 patients and the healthy group found that CVI, LA and TCA significantly decreased in the patient group.…”

Section: Discussionsupporting

confidence: 68%

See 1 more Smart Citation

Investigation of changes in retinal vascular parameters and choroidal vascular index values during the early recovery period of COVID-19: The COVID-OCTA study

Beyoğlu

Küçüködük

Meşen

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Section: Discussionsupporting

confidence: 68%

“…Similarly, other studies found that the central foveal and choroidal thicknesses decreased in the COVID-19 group, but this decrease did not reach statistical significance [ 33 , 34 ]. On the contrary, Abrishami et al stated that the subfoveal nasal and temporal ChT was measured higher in the active period of the disease [31] .…”

Section: Discussionmentioning

confidence: 70%

Investigation of changes in retinal vascular parameters and choroidal vascular index values during the early recovery period of COVID-19: The COVID-OCTA study

Beyoğlu

Küçüködük

Meşen

et al. 2023

Photodiagnosis and Photodynamic Therapy

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“…Others showed a decreased CVI during the COVID-19 disease with a reversible fashion some months after discharge, suggesting reversible and multiple mechanisms (ischemic and inflammatory) of COVID-19 on ocular perfusion [ 17 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Choroidal and Retinal Vascular Findings in Patients with COVID-19 Complicated with Pneumonia: Widefield Imaging

et al. 2023

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Purpose: The purpose of this study was to analyze choroidal and retinal vascular alterations of both the macula and midperiphery areas in patients hospitalized for COVID-19 infection complicated with pneumonia within 30 days from discharge. Methods: A total of 46 eyes of 23 subjects with a history of symptomatic COVID-19 infection and recent hospitalization for pneumonia were enrolled in this observational study. Patients had not been previously vaccinated against COVID-19. A group of patients homogenous for age and sex was enrolled as controls. Microvascular retinal and choroidal features of the enrolled patients were studied with widefield optical coherence tomography angiography (OCT-A). Perfusion parameters in terms of the vessel density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and the choroidal vascularity index (CVI) on enhanced depth imaging (EDI) mode OCT scans were analyzed. Results: Our cohort of patients showed a trend of reduction in VD, significantly in the SCP VD of the superior and inferior midperiphery sectors, whereas the CVI did not show significant differences between the cases and controls. Moreover, a positive correlation between CVI and vessel density in the deep capillary plexus in the macular area (VD-DCP-MAC) was found. Conclusion: The systemic disease due to COVID-19 can also involve the retina and choroid with multiple mechanisms: ischemic and inflammatory. Our study showed changes in perfusion occurring in the eyes of patients with a recent hospitalization for COVID-19 complicated with pneumonia and without any possible ocular effect due to the vaccines. There is still the need to better comprise how long COVID-19 actually affects vascular changes in the eye.

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“…In a recent preprint, Kocamis and associates [10] investigated the choroidal alterations in patients with COVID-19 and demonstrated a lower amount of CVI in patients with COVID-19 than healthy control eyes. Despite the apparent difference between the present study results, our results cannot be compared with the mentioned study for several reasons.…”

Section: Discussionmentioning

confidence: 99%

“…While the validity of these findings has been questioned by attributing the lesions to the normal retinal vessels [8], later studies also confirmed the retinal microvascular changes [4,9]. In addition to retinal manifestations, choroid can also be involved during the disease course [10,11].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Alterations of Retinal and Choroidal Structure in Patients Recovered from COVID-19

Abrishami

Hassanpour

Zamani

et al. 2022

Journal of Ophthalmology

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Objective. To evaluate the midterm longitudinal changes in chorioretinal structures in patients with coronavirus disease 2019 (COVID-19). Methods. Thirty-four eyes of 17 COVID-19 patients were enrolled. The patients underwent retinal and choroidal imaging upon the recovery (baseline) after 1 and 3 months. Retinal measurements in fovea, parafovea, and perifovea were recorded. To calculate choroidal vascularity index (CVI), luminal and total choroidal areas were measured using Sonada's method. Choroidal thickness was measured at the subfovea 500 microns temporal and nasal to the fovea. Results. Mean CVI was 0.64 ± 0.04 at baseline that significantly increased to 0.67 ± 0.05 (P = 0.012) after 1 month and again significantly decreased to 0.63 ± 0.05 after 3 months (P < 0.001). While the stromal component showed a significant decrease between the baseline and first-month values (1.16 ± 0.29 to 1.01 ± 0.27, P = 0.03), the luminal area mostly changed between months 1 and 3 (2.03 ± 0.28 to 1.91 ± 0.23, P = 0.045). The average of subfoveal choroidal thickness and retinal thickness remained unchanged. Conclusion. CVI is increased in patients with COVID-19 1 month after recovery from COVID-19 and returns to baseline values after 3 months. Regarding the reversible nature of changes, there might be a prominent role in inflammation.

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Structural alterations of the choroid evaluated using enhanced depth imaging optical coherence tomography in patients with coronavirus disease

Cited by 3 publications

References 0 publications

Investigation of changes in retinal vascular parameters and choroidal vascular index values during the early recovery period of COVID-19: The COVID-OCTA study

Investigation of changes in retinal vascular parameters and choroidal vascular index values during the early recovery period of COVID-19: The COVID-OCTA study

Choroidal and Retinal Vascular Findings in Patients with COVID-19 Complicated with Pneumonia: Widefield Imaging

Longitudinal Alterations of Retinal and Choroidal Structure in Patients Recovered from COVID-19

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