Serous retinal detachment as an early manifestation of lupus choroidopathy

Ghem, Mariela Regina Dalmarco; Hungaro, Anne Caroline; Hokazono, Kenzo

doi:10.5935/0004-2749.20210097

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Serous retinal detachments may be present in lupus choroidopathy, but the absence of choroidal thickening with specific systemic features helps in differentiating this disease [75].…”

Section: Systemic Lupus Erythematosus Chorioretinopathymentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease: Current Diagnosis and Management

Goyal,

Shah,

Anantharaman

et al. 2024

Uveitis - Basics, Diagnosis, and Treatment

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Vogt-Koyanagi-Harada (VKH) disease is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin, and hair. This disease is mainly a T1 lymphocyte-mediated aggression to melanocytes. The availability of new investigational methods has improved our knowledge of the pathogenesis, clinical approach, diagnosis, and management of VKH disease. The disease has an acute onset of bilateral blurred vision with hyperemia in the absence of prior ocular trauma or any previous intraocular surgery. The chronic phase comprises of ocular and integumentary system pigmentary changes. Ocular findings may be accompanied by meningismus, hearing impairment, and skin lesions in a variable proportion of patients. Prompt diagnosis with early, aggressive, and long-term treatment of high-dose corticosteroids ensures good visual outcomes. The aim of this chapter is to present the clinicopathology, classification, recent imaging, investigations, and management of VKH disease.

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“…Serous retinal detachments may be present in lupus choroidopathy, but the absence of choroidal thickening with specific systemic features helps in differentiating this disease [75].…”

Section: Systemic Lupus Erythematosus Chorioretinopathymentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease: Current Diagnosis and Management

Goyal,

Shah,

Anantharaman

et al. 2024

Uveitis - Basics, Diagnosis, and Treatment

View full text Add to dashboard Cite

show abstract

“…LC is rarely seen in clinics compared with LR, and no more than 60 cases have been reported to date ( 13 , 33 – 35 ). It commonly manifests with bilateral serous or exudative retinal detachment, an increase in choroidal thickness, and the presence of subretinal deposits corresponding to immune complexes ( 36 , 37 ).…”

Section: Ocular Fundus Manifestations In Systemic Lupus Erythematosusmentioning

confidence: 99%

Ocular fundus changes and association with systemic conditions in systemic lupus erythematosus

Meng,

Wang,

Yang

et al. 2024

Front. Immunol.

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Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and systems. Ocular involvement is estimated to manifest in one-third of individuals with SLE, of which lupus retinopathy and choroidopathy represent the severe subtype accompanied by vision impairment. Advancements in multimodal ophthalmic imaging have allowed ophthalmologists to reveal subclinical microvascular and structural changes in fundus of patients with SLE without ocular manifestations. Both ocular manifestations and subclinical fundus damage have been shown to correlate with SLE disease activity and, in some patients, even precede other systemic injuries as the first presentation of SLE. Moreover, ocular fundus might serve as a window into the state of systemic vasculitis in patients with SLE. Given the similarities of the anatomy, physiological and pathological processes shared among ocular fundus, and other vital organ damage in SLE, such as kidney and brain, it is assumed that ocular fundus involvement has implications in the diagnosis and evaluation of other systemic impairments. Therefore, evaluating the fundus characteristics of patients with SLE not only contributes to the early diagnosis and intervention of potential vision damage, but also holds considerate significance for the evaluation of SLE vasculitis state and prediction of other systemic injuries.

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Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report

Sadeghi,

Pashapouryeganeh,

Karimi

et al. 2023

J Med Case Reports

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Background The aim of this report is to highlight the importance of considering nephrotic syndrome as a potential underlying cause of bilateral central serous retinal detachment in a patient with systemic lupus erythematosus and to underscore the significance of a comprehensive systemic workup in these patients. Case presentation A 19-year-old Iranian female patient with history of systemic lupus erythematosus presented with progressive vision loss and bilateral macular elevation. Ophthalmic examination revealed periorbital edema, chemosis, and subretinal fluid at the macula of both eyes. Optical coherence tomography confirmed the existence of subretinal fluid and serous detachment located at the macula of both eyes. On fluorescein angiography, there were no signs of subretinal leakage such as smoke stack sign or expansile dot in late phases. Laboratory tests detected hypoalbuminemia and significant proteinuria, leading to the diagnosis of nephrotic syndrome. Treatment with prednisolone and albumin infusion resulted in improved visual acuity and resolution of subretinal fluid. Conclusion Nephrotic syndrome can be a rare underlying cause of bilateral central serous retinal detachment, and its association with systemic lupus erythematosus should be considered. Hypoalbuminemia in nephrotic syndrome alters fluid dynamics in the retina, contributing to bilateral central serous retinal detachment. Early recognition and management of nephrotic syndrome are essential for vision recovery and preventing long-term complications.

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Serous retinal detachment as an early manifestation of lupus choroidopathy

Cited by 3 publications

References 10 publications

Vogt-Koyanagi-Harada Disease: Current Diagnosis and Management

Vogt-Koyanagi-Harada Disease: Current Diagnosis and Management

Ocular fundus changes and association with systemic conditions in systemic lupus erythematosus

Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report

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