“…This study, along with subsequent post mortem analyses of irises and iridectomy specimens from 25- to 72-year-old individuals, revealed significant iris thinning with atrophy of the stroma, displaying a normal ultrastructure and abundant collagen fibrils but greater numbers of fibroblasts and melanocytes in the ground substance [ 11 , 28 , 32 , 34 , 35 , 36 , 37 ]. Consistent with the observation of partial or total dilation inability among affected individuals, varying dilator muscle anomalies have also been described—from peripheral to generalized dearth or absence of stromal contractile processes of the anterior iris epithelium [ 8 , 9 , 10 , 11 , 21 , 34 , 35 , 38 , 39 ]. Existing myofibrils can be normal in appearance, particularly behind the sphincter muscle and in the intermediary region [ 33 ], or greatly disordered and lack myofilaments and desmin [ 9 , 28 , 33 , 34 , 35 , 37 ].…”