Relationship between erythrocyte sedimentation rate and choroidal and retinal
            thickness in Behçet’s disease

Yuvacı, İsa; Sırakaya, Ender; Pangal, Emine; Ataş, Mustafa; Bayram, Nurettin; Güler, Emel; Demir, Fatmagül Ülkü; Altunel, Orhan

doi:10.5935/0004-2749.20190059

Cited by 2 publications

(5 citation statements)

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“…16 However, the most affected macular sector in BU varies in the literature. 21,23,25,26 Similar to our findings, vascular abnormalities in the macular region have been observed in the nasal parafoveal sector, 18,19 which might be more prone to ischemic damage because of a higher density of unmyelinated nerve fibers with high metabolic demand, resulting in a substantial imbalance between energy supply and demand. 19,23,24 Most OCTA publications have divided the retinal vascular system into superficial and deep vascular complexes.…”

Section: Discussionsupporting

confidence: 89%

“…Concerning subfoveal choroidal thickness in patients with BS, the literature is controversial. 6,9,26 Although we did not find intergroup differences, the more important involvement of nasal macula in BS, an ischemic and vasoocclusive condition, could be explained by correspondent choroidal thinning. 27 Further studies should be performed to clarify this finding.…”

Section: Discussioncontrasting

confidence: 67%

“…23,24 Previous publications on BU had described localized defects in the posterior pole and the peripapillary area of the RNFL, mainly in the nasal sector. 15,25,26 Interestingly, we found no intergroup differences in RNFL thickness, possibly because of the more central macular area definition. Concerning subfoveal choroidal thickness in patients with BS, the literature is controversial.…”

Section: Discussionmentioning

confidence: 58%

“…Our OCT, OCTA, and microperimetry findings suggest a predilection for the nasal macular sector in BS vasculitis, in agreement with previous studies. 15,18,19,[25][26][27] Our study had some limitations. First, the small sample size limited our ability to detect minimal intergroup differences.…”

Section: Discussionmentioning

confidence: 94%

“…Our OCT, OCTA, and microperimetry findings suggest a predilection for the nasal macular sector in BS vasculitis, in agreement with previous studies. 15,18,19,25–27…”

Section: Discussionmentioning

confidence: 99%

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Optical Coherence Tomography Angiography Biomarkers and Microperimetry Features in Behçet's Uveitis

Ferreira

Higashi

Prado

et al. 2023

Retina

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Purpose: To evaluate the parafoveal macular microvasculature and the macular function in patients with retinal vasculitis associated with Behçet's uveitis (BU). Methods: In 14 patients with inactive BU and 26 control individuals (13 with nonocular Behçet's syndrome and 13 healthy subjects), we analyzed the retinal nerve fiber layer, ganglion cell layer (GCL), full retinal thickness (FRT), foveal avascular zone area and sectorial parafoveal vessel density in the superficial vascular plexus, intermediate capillary plexus, and deep capillary plexus (DCP) using Spectralis optical coherence tomography (OCT) 2 and OCT angiography (OCTA). Macular sensitivity was analyzed using an MP-3 microperimeter. Results: Eighteen eyes (78%) had a best-corrected visual acuity (BCVA) > 20/25. Significant differences were found in BU in comparison to the controls on the OCT and OCTA: 14.8%, 22.4%, and 14.9% GCL thinning in the global, nasal, and inferior sectors, respectively; 6%, 13.2%, and 7.5% FRT thinning in the superior, nasal, and inferior sectors; and 16.8%, 14.9%, 23.6%, 15.8%, and 12.6% mean DCP density reduction in the global, superior, nasal, inferior, and temporal sectors. Microperimetry data demonstrated significant mean reductions of 21% and 23.6% in central and average macular sensitivities, and 28.8%, 40.4%, 27.7%, and 24.2% in the superior, nasal, inferior, and temporal sectors, respectively. Outer plexiform layer elevations were observed in BU (69.6%). Conclusions: BU presented structural and functional macular damage despite good BCVA, mainly affecting the nasal sector and the DCP. On OCT and OCTA, quantitative and qualitative changes can be valuable biomarkers of ocular involvement in BS.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 94%

“…Our OCT, OCTA, and microperimetry findings suggest a predilection for the nasal macular sector in BS vasculitis, in agreement with previous studies. 15,18,19,25–27…”

Section: Discussionmentioning

confidence: 99%

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