Effects of combined oral doxycycline and topical cyclosporine treatment
                        on ocular signs, symptoms, and tear film parameters in rosacea
                        patients

Bi̇lgi̇n, Burak; Karadağ, Ayşe Sevgi

doi:10.5935/0004-2749.20180093

Cited by 10 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Combination therapy to target specific features is necessary to achieve effective treatment, especially in patients with severe rosacea or multiple rosacea features [13,14]. Oral therapy combined with topical therapy [83], laser-/lightbased therapy combined with topical therapy [54], and a combination of topical therapies [84] have all been documented in recent publications. Fractional microneedling radiofrequency, a new device in dermatology, has also been used to treat recalcitrant papulopustular rosacea combined with pulsed dye laser and oral isotretinoin [85].…”

Section: Combination Therapiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.

show abstract

Section: Combination Therapiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

show abstract

“…Cyclosporine works by inhibiting T-lymphocytes and cytokines within the conjunctiva, thus reducing apoptosis and increasing tear production. 3,10 Topical cyclosporine is an acceptable long term treatment for management of ocular rosacea due to its favorable safety profile. 46 Overall, 88% of patients in our study treated with IPL achieved a complete or partial response.…”

Section: Discussionmentioning

confidence: 99%

“…‐ Partial Response (PR) : partial or moderate response based on criteria established by each included study. For example, achieving “significant improvement in ocular signs and symptoms” 10 ‐ No response (NR) : no response or worsening symptoms based on criteria established by each included study.…”

Section: Methodsmentioning

confidence: 99%

Treatment of ocular rosacea: a systematic review

Avraham,

Khaslavsky,

Kashetsky

et al. 2024

J Deutsche Derma Gesell

View full text Add to dashboard Cite

SummaryRosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty‐six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91% (n = 82/90) and 89% (n = 525/580) of patients respectively, followed by intense pulsed light (89%, n = 97/109 partial response), cyclosporine ophthalmic emulsion (87% n = 40/46), and lid hygiene (65%, n = 67/105). Combination treatments achieved a complete or partial response in 90% (n = 69/77). Results suggest that topical antimicrobials, oral antibiotics, intense pulsed light. and cyclosporine were the most efficacious single modality treatments.

show abstract

“…Significant improvement in ocular signs and symptoms was observed in both groups and between group differences were not significant ( p > .05). However, the combined cyclosporine and doxycycline group demonstrated improved tear function, based on Schirmer test and tear breakup time (TBUT, and to a greater extent than doxycycline alone ( p < .05) 132 …”

Section: Diagnosis and Classificationmentioning

confidence: 99%

Rosacea treatments: Current standards and additional options

Tan

Singh

Song

et al. 2021

Dermatological Reviews

View full text Add to dashboard Cite

Background Rosacea, a chronic facial and ocular inflammatory disease, is readily visible with consequential adverse psychosocial impacts. Progress in epidemiology, pathophysiology, treatments, psychosocial and quality of life impact has led to improved outcomes. Additionally, there has been a transition to updated clinical criteria for diagnosis and classification, the phenotype approach, based on rosacea‐associated features. Objective Our objective was to identify current evidence‐based standards of treatment for rosacea highlighting recently approved interventions and including innovative options. Methods Reviews establishing current standards of care published over the past three years and English language clinical studies of rosacea treatment from 2018‐ March 2021 were included. In addition to pivotal trials, the latter were also selected based on innovation and practicality of the intervention. Results In addition to treatments identified in guidelines and systematic reviews, additional options derive from use in other dermatological conditions ‐ such as botulinum toxin, hydroxychloroquine, photodynamic therapy, radiofrequency with or without microneedling ‐ or from other medical conditions, such as artemether and sumatriptan. Conclusion We provide a template of longitudinal care for rosacea based on features divided into current standards and additional options. The latter may provide the impetus for further research and development to provide options with greater efficacy, longer remissions and/or lower risk of adverse events to improve outcomes in patients with rosacea.

show abstract

Effects of combined oral doxycycline and topical cyclosporine treatment on ocular signs, symptoms, and tear film parameters in rosacea patients

Cited by 10 publications

References 0 publications

Rosacea Treatment: Review and Update

Rosacea Treatment: Review and Update

Treatment of ocular rosacea: a systematic review

Rosacea treatments: Current standards and additional options

Contact Info

Product

Resources

About