Treatment of ocular rosacea: a systematic review

Abstract

SummaryRosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty‐six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91% (n = 82/90) and 89% (n = 525/580) of patients respectively, followed by intense pulsed light (89%, n = 97/109 partial response), cyclosporine ophthalmic emulsion (87% n = 40/46), and lid hygiene (65%, n = 67/105). Combination treatments achieved a complete or partial response in 90% (n = 69/77). Results suggest that topical antimicrobials, oral antibiotics, intense pulsed light. and cyclosporine were the most efficacious single modality treatments.

Molecular Mechanisms in the Etiopathology of Rosacea—Systematic Review

“…Recent systematic reviews in the area of rosacea focus mainly on treatment [ 40 , 41 , 42 , 43 , 44 , 45 ], or disease burden [ 46 , 47 ] and the quality of life of patients with rosacea [ 48 ]. We identified only one recent systematic review dedicated to biomarkers in rosacea.…”

Molecular Mechanisms in the Etiopathology of Rosacea—Systematic Review

“…Recent systematic reviews in the area of rosacea focus mainly on treatment [ 40 , 41 , 42 , 43 , 44 , 45 ], or disease burden [ 46 , 47 ] and the quality of life of patients with rosacea [ 48 ]. We identified only one recent systematic review dedicated to biomarkers in rosacea.…”

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis

“……”

Rosacea in childhood and adolescence: A review

“…Systemic therapy is carried out using macrolides (azithromycin, erythromycin, roxithromycin), tetracyclines (doxycycline, minocycline), or metronidazole for at least 3 to 6 months. 49 , 54 …”

Molecular Mechanisms in the Etiopathology of Rosacea—Systematic Review

“…Recent systematic reviews in the area of rosacea focus mainly on treatment [ 40 , 41 , 42 , 43 , 44 , 45 ], or disease burden [ 46 , 47 ] and the quality of life of patients with rosacea [ 48 ]. We identified only one recent systematic review dedicated to biomarkers in rosacea.…”

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis

“……”

Rosacea in childhood and adolescence: A review

“…Systemic therapy is carried out using macrolides (azithromycin, erythromycin, roxithromycin), tetracyclines (doxycycline, minocycline), or metronidazole for at least 3 to 6 months. 49 , 54 …”

Molecular Mechanisms in the Etiopathology of Rosacea—Systematic Review

“…Recent systematic reviews in the area of rosacea focus mainly on treatment [ 40 , 41 , 42 , 43 , 44 , 45 ], or disease burden [ 46 , 47 ] and the quality of life of patients with rosacea [ 48 ]. We identified only one recent systematic review dedicated to biomarkers in rosacea.…”

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis

“……”

Rosacea in childhood and adolescence: A review

“…Systemic therapy is carried out using macrolides (azithromycin, erythromycin, roxithromycin), tetracyclines (doxycycline, minocycline), or metronidazole for at least 3 to 6 months. 49 , 54 …”