Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen
            mustard-induced ocular injury

İlhan, Abdullah; Yolcu, Ümit; Öztaş, Emin; Erdem, Üzeyir

doi:10.5935/0004-2749.20180045

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[15,16] Accumulating evidence shows that natural medicinal compounds from plants and fruits possess strong antiglycation ability in DR. [17] Proanthocyanidins (PACs) are polyphenols found in various plant and fruit extracts, which have been reported to exert powerful antioxidant, immunosuppressive, and anti-inflammatory functions. [18,19] Recent research has demonstrated that PACs could protect the RPE from vitamin A dimer-mediated photooxidation damage by reducing the apoptosis rate, increasing the ratio of B-cell lymphoma-2 (Bcl-2)/ Bcl-2-associated X (Bax), attenuating ROS production, and decreasing caspase cleavage. [20] Moreover, the retinal layer of diabetic rats was shown to be disorganized with shrunken nerve fibers, whereas treatment with PACs improved the retinal structure and reduced apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome

Wang

et al. 2021

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is a common diabetic complication known to cause vision impairment and blindness. Previous studies have demonstrated that proanthocyanidins (PACs), polyphenols that are naturally found in several plants and fruits, have powerful antioxidant and anti-inflammatory effects on various cells. However, the effects and underlying mechanism of PACs against DR pathogenesis remain unknown. Here, we investigated the proliferation, apoptosis, and mechanisms of ARPE-19 cells in response to oxidative stress and inflammation under high-glucose conditions with or without PACs treatment. The Cell-Counting Kit-8 assay and western blot analysis showed that treatment with 10 μl PACs significantly increased cell proliferation and the expression level of Bcl-2 in ARPE-19 cells under highglucose conditions. Moreover, PACs attenuated the high glucose-induced apoptosis, and the increased expression levels of caspase-3 and Bax. Under high-glucose conditions, the generation of reactive oxygen species (ROS) and levels of malondialdehyde increased, whereas the superoxide dismutase content decreased.Moreover, the expression level of the NLRP3 inflammasome, and the release of interleukin 1β (IL-1β) and IL-18 increased. PACs reversed all of these high glucoseinduced effects on ARPE-19 cells. Additionally, exposure to nigericin sodium salt, an agonist of the NLRP3 inflammasome, upregulated expression of the NLRP3 inflammasome accompanied by the release of IL-1β and IL-18. Again, treatment with PACs markedly downregulated these effects. Collectively, these results demonstrate that PACs can prevent retinal pigment epithelial cells from high glucose-induced injury via inhibiting the generation of ROS and activation of the NLRP3 inflammasome, suggesting PACs as a potential candidate for the management of DR.

show abstract

Section: Introductionmentioning

confidence: 99%

Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome

Wang

et al. 2021

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies

Gao,

Tao,

Jiang

2023

Redox Report

View full text Add to dashboard Cite

Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury

Abstract: Our results indicate that PAC and CoQ10 treatments have therapeutic effects on NM-induced ocular injury in a rat model. PAC and CoQ10 may be novel options in patients with NM-induced ocular injury.

Cited by 2 publications

References 0 publications

Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome

Proanthocyanidins attenuate the high glucose‐induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome

Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies

Contact Info

Product

Resources

About