Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies

Gao, Jie; Tao, Liming; Jiang, Zhengxuan

doi:10.1080/13510002.2023.2272386

Cited by 3 publications

(2 citation statements)

References 128 publications

(132 reference statements)

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“…As previously discussed, oxidative stress and endothelial dysfunction play pivotal roles in promoting the complications related to DR [169]. ROS, particularly O 2…”

Section: Antioxidant Therapymentioning

confidence: 87%

See 1 more Smart Citation

Diabetic Retinopathy: New Treatment Approaches Targeting Redox and Immune Mechanisms

Tang,

Buonfiglio,

Böhm

et al. 2024

Antioxidants

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Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus, characterized by irreversible visual impairment resulting from microvascular abnormalities. Since the global prevalence of diabetes continues to escalate, DR has emerged as a prominent area of research interest. The development and progression of DR encompass a complex interplay of pathological and physiological mechanisms, such as high glucose-induced oxidative stress, immune responses, vascular endothelial dysfunction, as well as damage to retinal neurons. Recent years have unveiled the involvement of genomic and epigenetic factors in the formation of DR mechanisms. At present, extensive research explores the potential of biomarkers such as cytokines, molecular and cell therapies, antioxidant interventions, and gene therapy for DR treatment. Notably, certain drugs, such as anti-VEGF agents, antioxidants, inhibitors of inflammatory responses, and protein kinase C (PKC)-β inhibitors, have demonstrated promising outcomes in clinical trials. Within this context, this review article aims to introduce the recent molecular research on DR and highlight the current progress in the field, with a particular focus on the emerging and experimental treatment strategies targeting the immune and redox signaling pathways.

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“…As previously discussed, oxidative stress and endothelial dysfunction play pivotal roles in promoting the complications related to DR [169]. ROS, particularly O 2…”

Section: Antioxidant Therapymentioning

confidence: 87%

“…As previously discussed, oxidative stress and endothelial dysfunction play pivotal roles in promoting the complications related to DR [169]. ROS, particularly O2 •− , adversely affect the vasorelaxation and endothelial protective factor NO by uncoupling eNOS.…”

Section: Antioxidant Therapymentioning

confidence: 91%