Characteristics of the cornea in patients with pseudoexfoliation syndrome

Oltulu, Refik; Şatırtav, Günhal; Kayitmazbatir, Emine Tinkir; Bitirgen, Gulfi dan; Özkağnıcı, Ahmet; Karaibrahimoğlu, Adnan

doi:10.5935/0004-2749.20150092

Cited by 17 publications

(11 citation statements)

References 10 publications

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“…[131415161718192021222324252627282930313233343536] Additionally, patients with PEX were found to have decreased keratocyte stromal cell counts, basal corneal epithelial cell counts, and sub-basal neural integrity[13142336] which has been correlated to the decreased corneal sensitivity seen in PEX patients. [1213] However, it is less clear as to whether patients with PEXG have more severe corneal alterations than PEX alone without secondary glaucoma, or if these corneal alterations can be utilized in the clinic to help manage patients at risk of developing or already with glaucomatous damage associated with PEX.…”

Section: Introductionmentioning

confidence: 99%

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Palko

Sheybani

2017

J Ophthalmic Vis Res

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A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Library databases published prior to September of 2016. We then screened the references of these retrieved papers and performed a Web of Science cited reference search. Corneal characteristics analyzed included central corneal thickness (CCT), corneal nerve density, endothelial cell density (ECD), polymegathism, and pleomorphism. These parameters were compared in the following populations: control, PEX, PEXG, and primary open angle glaucoma (POAG). Over 30 observational studies were reviewed. Most studies showed a statistically significant lower ECD in PEX and PEXG populations compared to controls. Overall, PEX eyes had a non-statistically significant trend of lower ECDs compared to PEXG eyes. No consistent trends were found when analyzing differences in CCT amongst control, PEX and PEXG groups. For the few studies that looked at corneal nerve characteristics, the control groups were found to have statistically significantly greater nerve densities than PEX eyes, which had significantly greater densities than PEXG eyes. ECD and corneal nerve densities may be potential metrics for risk-stratifying patients with PEX and PEXG. Our literature review provided further evidence of the significant negative influence PEX has on the cornea, worsening as patients convert to PEXG.

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Section: Introductionmentioning

confidence: 99%

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Palko

Sheybani

2017

J Ophthalmic Vis Res

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“…Цен-тральным звеном оксидативного стресса является увеличение концентрации активных форм кисло-рода (АФК), которое вызывает образование сво-бодных радикалов, повреждение клеточных ма-кромолекул, которое приводит к дисфункции, а в дальнейшем и гибели клеток [26].…”

Section: Discussionunclassified

“…Все АФК являются окислителями кле-точных компонентов и в больших количествах не-обратимо повреждают клетки. Защита организ-ма от АФК осуществляется функционированием антиоксидантной системы [26]. Demirdögen et al сообщили о достоверно значимом низком уровне антиоксидантной защиты у пациентов с ПЭС и псевдоэксфолиативной глаукомой по сравнению с группой контроля и о том, что недостаток анти-оксидантов может вносить свой вклад в развитие этих двух патологических состояний [27].…”

Section: Discussionunclassified

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The influence of pseudoexfoliative syndrome on corneal morphology based on in vivo confocal microscopy

Потемкин

Витальевич²,

Varganova

et al. 2017

Ophthalmology Reports

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 Конфокальная микроскопия -современный метод исследования, позволяющий в режиме реального времени оценить неинвазивно in vivo структуру роговицы, лимба и конъюнктивы. Цель -оценить основные морфологические изменения роговицы, наблюдаемые при конфокальной микроскопии у пациентов с псевдоэксфолиативным синдромом (ПЭС). Материалы и методы. Был обследован 21 пациент. Основную группу составили 12 пациентов с ПЭС, группу контроля -9 пациентов без ПЭС. Результаты. У пациентов с ПЭС наблюдалось снижение плотности клеток эпителия и стромы роговицы, большое количество гиперрефлективных межклеточных микровключений и дендритических клеток (p < 0,05). Ключевые слова: конфокальная микроскопия; псевдоэксфолиативный синдром.  Confocal microscopy is a modern examination method, which provides in real-time mode a noninvasive in vivo imaging of the cornea, limb, and conjunctiva. Purpose. To evaluate main morphological changes observed by confocal microscopy in patients with pseudoexfoliation (PEX) syndrome. Methods. 21 patients were examined. 12 patients with PEX syndrome were enrolled as the main group, and 9 patients without PEX -as controls. Results. In patients with PEX, there was a decreased cell density in the epithelium and the stroma of the cornea, as well as a lot of hyperreflective intercellular microdeposits and dendritic cells (p < 0.05). THE INFLUENCE OF PSEUDOEXFOLIATIVE SYNDROME ON CORNEAL MORPHOLOGY BASED ON IN VIVO CONFOCAL MICROSCOPY Key words: confocal microscopy; pseudoexfoliation syndrome. ВВЕДЕНИЕПсевдоэксфолиативный синдром (ПЭС) -системное, ассоциированное с возрастом забо-левание, для которого характерна продукция и накопление внеклеточного амилоидподобного материала [3,[5][6][7]. ПЭС поражает множество тканей и органов, но именно офтальмологиче-ские проявления являются основой для поста-новки диагноза [3,4,6]. Это возможно благо-даря тому, что рутинного биомикроскопического исследования достаточно для обнаружения псев-доэксфолиативного материала (ПЭМ). Типичным

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“…Wang et al noted decreased mean corneal endothelial cell density in a small cohort of eyes of Chinese patients with pseudoexfoliation (39). Other groups have taken this a step further, finding decreased endothelial cell, anterior stromal keratocyte, and posterior stromal keratocyte density as well as decreased length, branching, and density of the sub-basal nerve plexus (40, 41). Pseudoexfoliation syndrome has also been associated with decreased tear production and tear film stability (42, 43).…”

Section: Ocular Manifestationsmentioning

confidence: 99%

Genetics, Diagnosis, and Monitoring of Pseudoexfoliation Glaucoma

Nathan

Kuchtey

2016

Curr Ophthalmol Rep

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Recent studies have shed new light on the genetic factors underlying pseudoexfoliation syndrome, growing our understanding of the role of the lysyl oxidase-like 1 (LOXL1) gene and its various polymorphisms as well as identifying new genetic associations. Recent years have brought new insight on how these genetic factors interact with other factors, including environmental, to confer risk to individuals and populations worldwide. All of these findings may hold importance to the screening, diagnosis, and monitoring of pseudoexfoliation and may also help lead to the identification of novel therapeutic targets. This review serves as an update on the recent trends and findings in pseudoexfoliation syndrome.

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Characteristics of the cornea in patients with pseudoexfoliation syndrome

Cited by 17 publications

References 10 publications

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: A literature review

The influence of pseudoexfoliative syndrome on corneal morphology based on in vivo confocal microscopy

Genetics, Diagnosis, and Monitoring of Pseudoexfoliation Glaucoma

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