Ophthalmic Doppler in persistent hyperplastic primary vitreous atypical presentation: case report

Morales, Maira Saad de Ávila; Tartarella, Márcia Beatriz; Gouveia, Enéias Bezerra; Mandello, Maria Helena; Allemann, Norma

doi:10.5935/0004-2749.20150084

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…B-scan ultrasound reveals the extent of posterior segment involvement while Doppler imaging can demonstrate blood flow within hyaloid remnants [75,76]. Infants with suspected PFV should thus undergo B-Scan ultrasonography before surgery to exclude other vitreous or retinal pathology.…”

Section: Basic Surgical Techniquesmentioning

confidence: 99%

Cataract management in children: a review of the literature and current practice across five large UK centres

Self

Taylor

Solebo

et al. 2020

Eye

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Congenital and childhood cataracts are uncommon but regularly seen in the clinics of most paediatric ophthalmology teams in the UK. They are often associated with profound visual loss and a large proportion have a genetic aetiology, some with significant extra-ocular comorbidities. Optimal diagnosis and treatment typically require close collaboration within multidisciplinary teams. Surgery remains the mainstay of treatment. A variety of surgical techniques, timings of intervention and options for optical correction have been advocated making management seem complex for those seeing affected children infrequently. This paper summarises the proceedings of two recent RCOphth paediatric cataract study days, provides a literature review and describes the current UK 'state of play' in the management of paediatric cataracts.

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Section: Basic Surgical Techniquesmentioning

confidence: 99%

Cataract management in children: a review of the literature and current practice across five large UK centres

Self

Taylor

Solebo

et al. 2020

Eye

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“…This is especially true for patients with opaque media leading to inconclusive clinical diagnosis (Wells, Miro & Brummond 1991;Ido et al 2007;Dimitrova & Kato 2010;Neudorfer et al 2012;Hu et al 2014;Morales et al 2015;Hu et al 2016). However, both diseases share similar clinical and ultrasonographic characteristics, in the form of vascularized retrolental tissue (Wells, Miro & Brummond 1991;Ido et al 2007;Dimitrova & Kato 2010;Neudorfer et al 2012;Morales et al 2015;Hu et al 2016). We confirmed that there was no difference between patients with PFV or RD using structural ultrasonography or qualitative analysis of the vascularization of the retrolental tissue alone, limiting their interest in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Our results are in line with previous studies showing that B-mode ultrasonography and qualitative CDFI may be useful for diagnosing and classifying PFV or RD or to guide surgery. This is especially true for patients with opaque media leading to inconclusive clinical diagnosis (Wells, Miro & Brummond 1991;Ido et al 2007;Dimitrova & Kato 2010;Neudorfer et al 2012;Hu et al 2014;Morales et al 2015;Hu et al 2016). However, both diseases share similar clinical and ultrasonographic characteristics, in the form of vascularized retrolental tissue (Wells, Miro & Brummond 1991;Ido et al 2007;Dimitrova & Kato 2010;Neudorfer et al 2012;Morales et al 2015;Hu et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, RD may share similar morphological features (Coleman & Jack 1973;Ido et al 2007). Colour Doppler flow imaging (CDFI) seemed promising in the diagnosis of PFV by showing blood flow in the retrolental tissue (Wells, Miro & Brummond 1991;Neudorfer et al 2012;Morales et al 2015;Hu et al 2016). However, RD may share similar qualitative CDFI features, thus limiting its relevance in clinical practice to distinguish PFV from RD (Han et al 2001;Ido et al 2007;Dimitrova & Kato 2010).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of Quantitative Colour Doppler Flow imaging in distinguishing Persistent Fetal Vasculature from Retinal Detachment

Chiaroni

Chapron

Purcell

et al. 2021

Acta Ophthalmologica

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Purpose: Distinguishing posterior persistent fetal vasculature (PFV) from retinal detachment (RD) may be very challenging clinically and ultrasonographically, as they share common morphological features. However, it is crucial, considering their substantially distinct management and treatment. We aimed to assess the relevance of quantitative colour Doppler flow imaging to distinguish PFV from RD in children. Methods: This retrospective bi-centre study included 66 children (30 females and 36 males, mean age: 244 AE 257 days) with a clinically suspected diagnosis of RD or posterior PFV. All children underwent systematic and standardized conventional ultrasonography and colour Doppler flow imaging under general anaesthesia with a qualitative and quantitative analysis of the retrolental tissue's vascularization. Peak systolic velocity, end-diastolic velocity and resistive index were recorded for analysis. Whenever available, surgical findings were deemed gold standard for diagnosis. A Mann-Whitney U-test was used to compare quantitative colour Doppler flow imaging data. Results: Peak systolic velocity and end-diastolic velocity were significantly lower in children with PFV versus RD: 2.7 (IQR: 0.5) versus 5.1 (IQR: 2.8), p < 0.001, and 0.0 (IQR: 0.0) versus 2.0 (IQR: 1.2), p < 0.001, respectively. Resistive index was significantly higher in children with PFV versus RD: 1 (IQR: 0) versus 0.6 (IQR: 0.1), p < 0.001. Area under curves (AUCs) were of 0.94, 0.99 and 1, respectively. No differences between PFV and RD were observed on structural ultrasound or qualitative analysis of colour Doppler. Conclusion: Quantitative colour Doppler flow imaging has an excellent accuracy in distinguishing PFV from RD in children. It may help to improve management and treatment.

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“…It is the second most common cause of acquired cataract during the first year of life 2. It is unilateral in around 90%–95% of cases and sporadic in nature.…”

Section: Introductionmentioning

confidence: 99%

Bilateral persistent fetal vasculature: mimicker of retinoblastoma

Kumar¹,

Yadav

2017

BMJ Case Reports

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We describe a case of bilateral persistent fetal vasculature (PFV) in a 3-month-old boy who presented with bilateral white pupillary reflex and a possible diagnosis of retinoblastoma. On ultrasonography, there was an echogenic band in the posterior segment of both eyes which connected the posterior surface of the lens capsule to the optic disc. Colour Doppler revealed the presence of vascularity in the band along its entire length. No calcification or mass lesion was seen. These findings are diagnostic of PFV. Most cases of PFV are unilateral and sporadic in nature and closely mimic retinoblastoma. Although rare, PFV should be considered in the differential diagnosis when examining a case of bilateral leukocoria. Paediatricians should be aware of this rare but serious entity.

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Ophthalmic Doppler in persistent hyperplastic primary vitreous atypical presentation: case report

Cited by 6 publications

References 5 publications

Cataract management in children: a review of the literature and current practice across five large UK centres

Cataract management in children: a review of the literature and current practice across five large UK centres

Diagnostic accuracy of Quantitative Colour Doppler Flow imaging in distinguishing Persistent Fetal Vasculature from Retinal Detachment

Bilateral persistent fetal vasculature: mimicker of retinoblastoma

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