Evaluation of possible factors affecting contrast sensitivity function in patients with primary Sjögren’s syndrome

Arıkan, Sedat; Gökmen, Ferhat; Çömez, Arzu Taşkıran; Gencer, Baran; Kara, Selçuk; Akbal, Ayla

doi:10.5935/0004-2749.20150039

Cited by 6 publications

(2 citation statements)

References 26 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the multiple regression analysis showed that visual impairment was associated with retinal thinning. This is in agreement with previous studies demonstrating that the ganglion cell inner plexiform and retinal nerve fiber layers were thinner in patients with SS compared with healthy subjects ( 37 , 38 ). In healthy subjects, the inner RT is negatively correlated with age ( 39 ), which may be due to the loss of neurons, while the outer RT (especially RPE) may thicken with age ( 40 ).…”

Section: Discussionsupporting

confidence: 93%

Optical Coherence Tomography Angiography Biomarkers of Retinal Thickness and Microvascular Alterations in Sjogren's Syndrome

Liu

Wang

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

PurposeTo investigate the differences of retinal thickness (RT) and superficial vascular density (SVD) between patients with Sjogren's syndrome (SS) and healthy controls (HCs) using optical coherence tomography angiography (OCTA).MethodsIndividuals with SS and healthy controls were enrolled (n = 12 per group). An en-face OCTA scan was performed on each eye. Images were segmented into 9 subregions and macular RT and SVD were measured and compared between the 2 groups.ResultsVisual acuity (VA) differed significantly between patients with SS (24 eyes) and controls (24 eyes) (p < 0.001). In patients with SS, inner RT was reduced in the inner superior region, outer RT was reduced in the outer nasal (ON) region, and full RT was reduced in the ON region compared with the control group (p < 0.05). RT was negatively correlated with serum IgG level in the outer and full retina at ON regions (p < 0.05). SVD in the inner nasal, ON, and inner temporal regions was significantly lower in patients with SS than in control subjects (p < 0.05). SVD was positively correlated with full RT in the ON region in patients with SS (p < 0.05). The areas under the receiver operating characteristic (ROC) curves for the diagnostic sensitivity of outer RT and full RT in the ON region for SS were 0.828 (95% CI: 0.709–0.947) and 0.839 (95% CI: 0.715–0.963), respectively.ConclusionsIn patients with SS, retinal thinning in the macular area—which affects vision—can also reflect the severity of dry eyes in SS and has clinical value for assisted imaging diagnosis.

show abstract

Section: Discussionsupporting

confidence: 93%

Optical Coherence Tomography Angiography Biomarkers of Retinal Thickness and Microvascular Alterations in Sjogren's Syndrome

Liu

Wang

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…We also evaluated pRNFL thickness by SD-OCT and identified reduced thicknesses in the temporal-inferior and the nasal-inferior sectors in SS patients compared with HC and SLE patients. Recent studies in SS patients have shown that the thickness of pRNFL in the inferior quadrants was compromised compared with HC due to dry eye disease or rarely optic neuropathy [44, 45]. This thinning might also be due to HCQ treatment or apoptosis of retinal ganglion cells induced by anti-Ro antibodies.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the Detection of Subclinical Retinal Involvement in Systemic Lupus Erythematosus and Sjögren Syndrome: A Potential Association with Therapies

Conigliaro

Triggianese

Draghessi

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Retinal involvement in systemic lupus erythematosus (SLE) and Sjögren syndrome (SS) may be subclinical and thus underdiagnosed. Objectives: We aimed at evaluating morphological and functional visual abnormalities in a cohort of SLE and SS patients in the absence of an overt clinical visual impairment. We also investigated potential associations between retinal disorders and disease activity, organ involvement, and treatment with steroid and/or hydroxychloroquine. Methods: The study comprised 42 SLE and 36 primary SS patients and 76 healthy controls (HC). Ophthalmological examination, standard automated perimetry, spectral-domain optical coherence tomography, and fundus perimetry were performed. Results: Retinal thickness of the posterior pole was not different between SLE and HC groups, but it was reduced in the SS group compared with both the HC and the SLE group. In SLE and SS patients, mean defect and pattern standard deviation by standard automated perimetry were higher than in HC. Visual field index values were lower in both SLE and SS patients than in HC. SLE patients with nephritis displayed increased mean defect and pattern standard deviation and reduced visual field index values compared to patients without nephritis. In SLE and SS patients, fundus perimetry differential sensitivity was reduced, and mean defect values were higher than in HC. Disturbances in fundus perimetry in the SLE group were more prevalent in steroid-naïve patients and in SS patients who received a cumulative hydroxychloroquine dose > 1,000 g. Conclusions: Functional eye impairment was demonstrated in SLE patients, possibly associated with kidney involvement. In SLE, corticosteroids might exert a protective role. Morphological alterations and functional impairment were detected in SS patients, which may be linked to hydroxychloroquine toxicity.

show abstract

Flammer and Sjögren Syndromes: What and Why Is in Common?

Baban

Golubnitschaja

2019

Flammer Syndrome

View full text Add to dashboard Cite

Evaluation of possible factors affecting contrast sensitivity function in patients with primary Sjögren’s syndrome

Cited by 6 publications

References 26 publications

Optical Coherence Tomography Angiography Biomarkers of Retinal Thickness and Microvascular Alterations in Sjogren's Syndrome

Optical Coherence Tomography Angiography Biomarkers of Retinal Thickness and Microvascular Alterations in Sjogren's Syndrome

Evidence for the Detection of Subclinical Retinal Involvement in Systemic Lupus Erythematosus and Sjögren Syndrome: A Potential Association with Therapies

Flammer and Sjögren Syndromes: What and Why Is in Common?

Contact Info

Product

Resources

About