Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography

Göktaş, Sertan; Başaran, Ahmet; Sakarya, Yaşar; Özçimen, Muammer; Kucukaydin, Zehra; Sakarya, Rabia; Başaran, Mustafa; Erdoğan, Erkan; Alpfidan, İsmail

doi:10.5935/0004-2749.20140038

Cited by 31 publications

(38 citation statements)

References 24 publications

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“…There are more than a dozen studies on choroidal thickness changes in pregnancy using enhanced depth imaging OCT, which have provided inconsistent results. [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Some studies have found thickening of the choroid in specific subfields during the second and third trimester of pregnancy, whereas other studies have observed no difference in choroidal thickness during pregnancy. The discrepancy in these studies could be due to variation in inclusion criteria, confounding factors (i.e.…”

Section: Discussionmentioning

confidence: 99%

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Chanwimol

Balasubramanian

Nassisi

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate retinal vascular status during pregnancy by using optical coherence tomography angiography (OCTA). METHODS. Women in their third trimester of pregnancy and nonpregnant age-matched women were recruited for this prospective, case-control study. Subjects were imaged with OCTA. Main outcome measures were foveal avascular zone parameters, perfusion density (PD) percentage in the superficial retinal capillary plexus (SCP), PD percentage in the deep retinal capillary plexus (DCP), SCP vessel length density (VLD), DCP-VLD, and choriocapillaris (CC) flow voids (i.e., flow deficits in the CC). RESULTS. Nineteen eyes of 10 pregnant subjects and 44 eyes of 27 nonpregnant control women were included. Mean ages were 36 6 7 and 35 6 8 years (SD), respectively (P value ¼ 0.78). Mean gestational age of pregnant women was 33 weeks (range ¼ 29-39, SD ¼ 3). There was a significant reduction in the SCP-PD in the entire scan and in the nasal Early Treatment Diabetic Retinopathy Study subfield (47.9 vs. 49.7, P ¼ 0.04 and 49.3 vs. 51.6, P ¼ 0.03, respectively) in the pregnant cohort versus controls. There was a significant increase in the DCP-PD in the parafoveal region and in the temporal and inferior Early Treatment Diabetic Retinopathy Study subfields (58.0 vs. 55.9, P ¼ 0.03; 57.9 vs. 55.5, P ¼ 0.02; 58.0 vs. 55.9, P ¼ 0.05, respectively) in the pregnant cohort. There was no significant difference in foveal avascular zone parameters, SCP-VLD, DCP-VLD, or CC flow voids between the two populations. CONCLUSIONS. This study detected retinal vasculature changes in the third trimester of pregnancy. Mean SCP-PD was significantly decreased and mean DCP-PD was significantly increased without a difference in VLD.

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Section: Discussionmentioning

confidence: 99%

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Chanwimol

Balasubramanian

Nassisi

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Finally, the stage of pregnancy at which each study group was imaged would impact SFCT, as evidenced by studies showing an upward trend of choroidal thickness in the first and second, followed by a decline in the third trimester. [24][25][26] We also investigated the correlation between SFCT and alternative indicators of disease severity, including maximum blood pressure and earlier GAs of delivery. We hypothesized that there would be a linear relationship between these alternative measures of preeclampsia severity and presence of ophthalmic findings.…”

Section: Clinical Interpretationmentioning

confidence: 99%

Subfoveal Choroidal Thickness and Associated Changes of Angiogenic Factors in Women with Severe Preeclampsia

et al. 2019

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Objective Severe preeclampsia complicates roughly 1% of all pregnancies. One defining feature of severe preeclampsia is new onset visual disturbance. The accessibility of the choroid to high-resolution, noninvasive imaging makes it a reasonable target of investigation for disease prediction, stratification, or monitoring in preeclampsia. This study aimed to compare subfoveal choroidal thickness between women with severe preeclampsia and those with normotensive pregnancies, and to investigate associations between such findings and other indicators of disease severity, including gestational age and serum angiogenic factors. Study Design We designed a case-control study comprised of 36 women diagnosed with severe preeclampsia (cases) matched to 37 normotensive women (controls) by race/ethnicity and parity, all diagnosed in the postpartum period. All patients underwent enhanced depth imaging spectral-domain optical coherence tomography and serum analysis. Results Cases showed no difference in subfoveal choroidal thickness compared with controls (p = 0.65). Amongst cases, subfoveal choroidal thickness and gestational age at delivery were inversely related (r = 0.86, p < .001). There was a positive association of placental growth factor with subfoveal choroidal thickness amongst cases (r = 0.54, p = 0.002). Conclusion This study suggests a relationship between the degree of disease severity and the magnitude of choroidal thickening. We also show an association between this index and placental growth factor level in the postpartum period.

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“…At different pregnant periods, changes in the CT have been found. Goktas et al [26] suggested that choroid could be thickened during the second trimester, and Dadaci et al [2] found that the CT was significantly decreased in healthy pregnant women during the third trimester compared to the first trimester. Second, except for those discussed above, there still exist variables that might differ among studies, such as the diopters of the eyes and the intraocular pressures.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis

Jiang

Yang

et al. 2019

Ophthalmic Res

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Purpose: To compare the choroidal thickness (CT) measured by enhanced depth imaging optical coherence tomography (EDI-OCT) in preeclamptic, healthy pregnant, and healthy nonpregnant women. Methods: Studies that focused on the CT evaluation of pregnant women were retrieved by searching PubMed, Embase, Ovid, Cochrane, and Web of Science. We used Stata 14.0 SE for the meta-analysis and presented the results as the weighted mean difference (WMD) with a corresponding 95% CI. Results: A total of 14 studies with 1,227 participants were included in our meta-analysis. The CT of the healthy pregnancies (μm, WMD = 34.19, 95% CI: 20.63–47.76) was significantly higher than that of the nonpregnancies (Test of WMD = 0: z = 4.94, p = 0.000), but the CT of the preeclampsia (μm, WMD = 54.30, 95% CI: –13.40 to 122.01) was not significantly different from the nonpregnancies (Test of WMD = 0: z = 1.57, p = 0.116). In the preeclampsia versus healthy pregnancy group, 3 studies found that the choroid was thinner with preeclampsia, only one study found the CT increased. Conclusions: This meta-analysis suggested that the CT of the healthy pregnant women was significantly higher than that of the nonpregnant women. The presence of preeclampsia might complicate this situation. Most studies found that the CT decreased in the preeclamptic patients because of the increases in the systemic vasospasm and the blood pressure, which led to no significant difference compared with the nonpregnant women.

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Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography

Cited by 31 publications

References 24 publications

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiography

Subfoveal Choroidal Thickness and Associated Changes of Angiogenic Factors in Women with Severe Preeclampsia

Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis

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