Desenvolvimento de adesivo tecidual fibrínico para uso experimental em perfurações corneanas

Adilson dos Anjos INTRODUÇÃOA busca da melhor técnica cirúrgica, assim como o melhor material de sutura a ser utilizado nas cirurgias de estrabismo inspiraram vários modelos experimentais com lesões induzidas em tecido muscular extra-ocular (1)(2)(3)(4)(5)(6) . Algumas características dos fios sintéticos podem ser responsáveis pela grande preferência dos cirurgiões, como, por exemplo, a maior força de tensão durante a fase de cicatrização e a maior rapidez de absorção uniforme. Por conseguinte, a menor reação inflamatória pós-operatória, decorrente da menor antigenicidade e, também, a facilidade e segurança relativa ao nó cirúrgico em relação aos fios de sutura utilizados anteriormente, explicam a maior utilização dos fios sintéticos (7)(8)(9) .Adesivo biológico de fibrina na mioescleropexia posterior em coelhos -Estudo experimental

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“…Além disso, o adesivo biológico apresenta um custo elevado, dificultando também o seu emprego freqüente em estudos experimentais (18) .…”

Section: Discussionunclassified

Adesivo biológico de fibrina na mioescleropexia posterior em coelhos: estudo experimental

Moreira¹,

Bottós²,

Bottós³

et al. 2004

Arq. Bras. Oftalmol.

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“…To overcome this problem, Bonati et al (2) recommended the use of tranexamic acid associated with fibrinogen, which delayed the plasmin fibrinolytic activity, contributing to the adhesive fixation for a longer period. Epsilon-aminocaproic acid has also been used in association with fibrinoid adhesives in order to decrease the tissue fibrinolytic activity and increase the permanence of the fibrin adhesive on the wound (30).…”

Section: Resultsmentioning

confidence: 99%

Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers: experimental study in dogs (Canis familiaris, Linnaeus, 1758)

Sampaio¹,

Ranzani²,

Brandão³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1 st , 3 rd , 7 th , 15 th , 30 th and 60 th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing.

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“…The fibrin glue was developed specifically to be employed in the treatment of experimental corneal perforation (16) .…”

Section: Development Of the Fibrin Gluementioning

confidence: 99%

A fibrin-related line of research and theoretical possibilities for the use of fibrin glue as a temporary basal membrane in non-perforated corneal ulcers and in photorefractive keratectomy (PRK)-operated corneas

Bonatti¹,

Bechara²,

Dall'Col³

et al. 2007

Arq. Bras. Oftalmol.

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Desenvolvimento de adesivo tecidual fibrínico para uso experimental em perfurações corneanas

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Adesivo biológico de fibrina na mioescleropexia posterior em coelhos: estudo experimental

Adesivo biológico de fibrina na mioescleropexia posterior em coelhos: estudo experimental

Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers: experimental study in dogs (Canis familiaris, Linnaeus, 1758)

A fibrin-related line of research and theoretical possibilities for the use of fibrin glue as a temporary basal membrane in non-perforated corneal ulcers and in photorefractive keratectomy (PRK)-operated corneas

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