Neurorretinite subaguda unilateral difusa: 3 casos no Estado do Paraná

Casella, Antônio Marcelo Barbante; Farah, Michel Eid; Bonomo, Pedro Paulo; Souza, Eduardo Cunha de

doi:10.5935/0004-2749.19940051

Cited by 8 publications

(4 citation statements)

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“…After several trials with oral antihelmintic drugs, such as thiabendazole and diethylcarbamazine, it was found that the tested drugs would only destroy the subretinal worms in some of their patients. Thereby, it was hypothesized that these antihelmintic drugs would depend on an inflamed eye (blood-retinal barrier breakdown), justifying the variable efficacy [20,[49][50][51][52].…”

Section: Oral Treatmentmentioning

confidence: 99%

Diffuse unilateral subacute neuroretinitis: review article

Mazzeo

Motta

Curi

2019

J Ophthal Inflamm Infect

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Diffuse unilateral subacute neuroretinitis (DUSN) is an ocular infectious disease that can lead to severe visual impairment and blindness. It usually occurs in healthy young individuals and depending on the stage of the disease, it may present as vitritis, multifocal gray-white lesions in the outer retina, and derangement of the retinal pigment epithelium, narrowing of the retinal vessels and optic atrophy. Parasites of different sizes and species have been proposed as the etiologic agent of DUSN, including Ancylostoma caninum, Toxocara canis, and others. Thus, it is hypothesized that different infectious worms may be considered as the likely cause of both an autoimmune and toxic form of nematode retinopathy. Because serologic testing is variable, the definitive diagnosis is made when clinical characteristics of DUSN are found in conjunction with an intraocular worm. Ancillary tests can assist in the differential diagnosis when the nematode cannot be visualized, such as fluorescein and indocyanine green angiography, electrophysiological tests, visual field studies, and more recently, optical coherence tomography angiography. Cases in which the worm can be identified, it is defined as confirmed DUSN, and eyes with the typical clinical features but without identification of the worm should be classified as presumed DUSN. In confirmed DUSN, the classic treatment is directly photocoagulation of the worm; however, it can only be visualized in 30% (to 40%) of cases. Treatment of presumed DUSN cases with high-dose oral albendazole has shown encouraging results. However, perhaps due to the disease's rarity or its underdiagnosis, there are no studies comparing current treatment modalities in both presumed and confirmed DUSN. Due to the possibility of this disease being, in part, autoimmune nematode retinopathy, corticosteroids associated with both albendazole or laser therapy, could be in any way beneficial. Thus, further comparative studies are necessary to elucidate the best treatment for this potentially blinding disease.

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Section: Oral Treatmentmentioning

confidence: 99%

Diffuse unilateral subacute neuroretinitis: review article

Mazzeo

Motta

Curi

2019

J Ophthal Inflamm Infect

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“…Other cases were subsequently documented with and without the presence of a worm. [16][17][18] Souza and Nagashima 19 surgically extracted an intact subretinal worm. Morphologic characteristics suggested Ancylostoma caninum, but some parasitologists believed it was a third-stage T. canis.…”

Section: Historymentioning

confidence: 99%

“…After several case series studies with oral antihelmintic drugs such as thiabendazole and diethylcarbamazine, these authors and others 18,42,43 found that the tested drugs would only destroy the subretinal worms in some of their patients. 42 Souza and colleagues 42 described 12 Brazilian patients who improved visual acuity, visual field, and active ocular inflammatory signs after treatment exclusively with high-dose oral albendazole (400 mg/d) for 30 days.…”

Section: Oral Treatmentmentioning

confidence: 99%

Diffuse Unilateral Subacute Neuroretinitis—DUSN

Garcia

Sabrosa²,

Gomes³

et al. 2008

International Ophthalmology Clinics

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“…Dentre as mais citadas destacam-se o Toxocara canis no Brasil e o Baylisascaris procyonis no noroeste dos Estados Unidos (1, 5-6, 10, 13-16, 18, 20) . (5,10,18,20,24) também são possíveis agentes.…”

Section: Introductionunclassified