2013
DOI: 10.5581/1516-8484.20130029
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Abstract: BackgroundThe Kell blood group system expresses high and low frequency antigens with the most important in relation to transfusion including the antithetic KEL1 and KEL2; KEL3 and KEL4; KEL6 and KEL7 antigens. Kell is a clinically relevant system, as it is highly immunogenic and anti-KEL antibodies are associated with hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. Although required in some situations, Kell antigen phenotyping is restricted due to technical limitations. In these… Show more

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Cited by 10 publications
(8 citation statements)
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“…The SNP causes an aminoacidic change at residue 193, from threonine (in K2) to methionine (in K1). This change eliminates a consensus sequence for glycosylation of residue 191 and may be responsible for the strong immunogenicity of the K1 antigen . The K1 antigen is the main antigen responsible for severe HDFN after the D antigen of the Rh blood group .…”
Section: Introductionmentioning
confidence: 99%
“…The SNP causes an aminoacidic change at residue 193, from threonine (in K2) to methionine (in K1). This change eliminates a consensus sequence for glycosylation of residue 191 and may be responsible for the strong immunogenicity of the K1 antigen . The K1 antigen is the main antigen responsible for severe HDFN after the D antigen of the Rh blood group .…”
Section: Introductionmentioning
confidence: 99%
“…KEL genotyping was performed in maternal genomic DNA by polymerase chain reaction (PCR) restriction fragment length polymorphism strategies [14] and showed KEL*02/02, KEL*04/04 and KEL*07/07 genotypes. Because of the discrepancy between serologic and molecular findings, each of the 19 exons of KEL gene and intron-exon boundaries were sequenced using the Sanger dideoxy method [15].…”
Section: Case Reportmentioning
confidence: 99%
“…Kell antigen phenotyping is hampered by technical limitations and genotyping can be of great assistance to solve this problem. The development of easy and efficacious strategies for KEL genotyping is fundamental to provide the needed information about the allelic frequency in multiethnic populations and to identify individuals with rare genotypes such as K*1/K*1 and K*3/K*3 (5) .…”
mentioning
confidence: 99%