Neonatal screening in the state of Piauí: an urgent need - a study on the prevalence of sickle cell disease in newborns

Soares, Leonardo Ferreira; Rocha, Oneide Angélica Monteiro dos Santos; Oliveira, Evaldo Hipólito de; Vieira, José Felipe Pinheiro do Nascimento

doi:10.5581/1516-8484.20120096

Cited by 1 publication

(1 citation statement)

References 5 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of HbS has been detected by neonatal screening in several Brazilian states, [20][21][22] and this study was the first to report it for Sergipe. Universal neonatal screening could identify affected babies before any symptoms, as well as asymptomatic heterozygous individuals, who can still transmit the gene to their offspring.…”

Section: Discussionmentioning

confidence: 73%

Spatial Distribution of Newborns With Sickle Cell Trait in Sergipe, Brazil

Leite

Cipolotti

Gurgel

et al. 2020

Rev. paul. pediatr.

View full text Add to dashboard Cite

who underwent neonatal screening in the public health system. Tests were carried out in basic health units and forwarded to the University Hospital laboratory, where they were analyzed. We used spatial autocorrelation (Moran's index) to assess the spatial distribution of heterozygous individuals with hemoglobinopathies.Results: Among 32,906 newborns, 1,202 showed other types of hemoglobin besides Hemoglobin A. We found a positive correlation between the percentage of black and multiracial people and the incidence of SCT. Most SCT cases occurred in the cities of Aracaju (n=273; 22.7%), Nossa Senhora do Socorro (n=102; 8.4%), São Cristóvão (n=58; 4.8%), Itabaiana (n=39; 4.2%), Lagarto (n=37; 4.01%), and Estância (n=46; 4.9%). Conclusions:The spatial distribution analysis identified regions in the state with a high frequency of HbS carriers. This information is important health care planning. This method can be applied to detect other places that need health units to guide and care for sickle cell disease patients and their families.

show abstract

Section: Discussionmentioning

confidence: 73%