Evidence of an association between the O blood group and allergic rhinitis

Falsarella, Nelson; Ferreira, Ana Iara da Costa; Nakashima, Fabiana; Mattos, Cinara Cássia Brandão de; Mattos, Luiz Carlos de

doi:10.5581/1516-8484.20110120

Cited by 14 publications

(16 citation statements)

References 22 publications

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“…In the future, researchers should assess the relationships by conducting similar studies in Asian populations. Finally, the results of this review showed that males are significantly more predisposed to allergic diseases than females 20 25 28. This finding is supported by other studies that have reported that the male gender poses a significant and independent risk factor for asthma and AR 40 41…”

Section: Discussionsupporting

confidence: 87%

“…Of the four studies related to AR, three studies reported that blood group O is correlated with AR25–27 (refer table 3A). No association was found in the fourth study3 (refer to table 3B).…”

Section: Resultsmentioning

confidence: 99%

“…In this review, several important insights were gained. First, in the selected studies, participants with blood group O were more susceptible than those with non-O blood groups to allergic diseases, especially AR and asthma 19 20 25–29. In contrast, those with non-O blood groups were more susceptible to AD 18 33 34.…”

Section: Discussionmentioning

confidence: 99%

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Association of ABO blood groups with allergic diseases: a scoping review

2020

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ObjectiveThe objective of this study was to map evidence of the association of ABO blood groups with allergic diseases such as allergic rhinitis (AR), atopic dermatitis (AD) and asthma.DesignA scoping review.Data sourcesPubMed, Scopus, Direct Open Access Journal, Medline, Cumulative Index to Nursing and Allied Health Literature, ScienceDirect and SpringerLink were searched from October 2017 until May 2018.Eligibility criteria for selecting studiesWe selected all types of studies including case-control studies, prospective or retrospective cohort studies, cross-sectional studies and experimental studies, and we included reviews such as literature reviews, systematic reviews with or without meta-analysis and scoping reviews that were published in English and associated the ABO blood group with the three allergic diseases (asthma, AR and AD) in humans of all age groups.Data extraction and synthesisTwo reviewers independently screened the titles and abstracts and assessed the full-text articles of the abstracts that met the eligibility requirements. Data from the included studies were extracted, evaluated and reported in the form of narrative synthesis.ResultsOf the 10 246 retrieved titles, only 14 articles were selected for a scoping review based on the eligibility criteria. The majority of the studies demonstrated a significant association between ABO blood groups and allergic diseases. We found that blood group O is prominent in patients with AR and asthma, while a non-O blood group is common in patients with AD.ConclusionThis scoping review serves as preliminary evidence for the association of ABO blood groups with allergic diseases. Further studies need to be conducted so that the relationship between ABO blood groups and allergic diseases can be fully established. This could be helpful for clinicians and health professionals in consulting and managing patients who suffer from allergic diseases in the future.

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Section: Discussionsupporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

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Association of ABO blood groups with allergic diseases: a scoping review

2020

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“…In Brazil, the patients with allergic rhinitis and controls were compared according to the frequencies of the ABO phenotypes. The O phenotype was significantly associated with allergic rhinitis in male but not in female patients (6).…”

Section: Discussionmentioning

confidence: 97%

“…Studies on adults and children with bronchial asthma have shown that asthma is significantly related to the O/non-secretor phenotype (4,5). Compared with controls, a significantly higher incidence of the O phenotype in male patients with allergic rhinitis was reported (6). Chronic rhinosinusitis (CRS) with NP is a frequent condition associated with bronchial asthma and allergic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

ABO and RhD Blood Groups in Nasal Polyposis

Jelavić

Marković

Klarić

et al. 2018

Turk Arch Otorhinolaryngol

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Objective: The aim of this study was to determine ABO and RhD blood group distribution in nasal polyposis (NP) patients and whether there is a specific ABO or RhD blood phenotype associated with susceptibility to or protection with respect to development of NP. Methods:The study group comprised 126 consecutive patients with chronic rhinosinusitis and bilateral NP. The control group comprised 126 healthy blood donors. All participants were from the same geographical region. Distribution of ABO and RhD phenotypes in all participants was studied.Results: There were no significant differences between patients and controls in the distribution of the A (p=0.520), B (p=0.306), AB (p=0.673), O (p=0.894), and RhD (p=0.742) phenotypes. Conclusion:According to the present results, the ABO and RhD blood group systems are not associated with development of NP.

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Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank

et al. 2021

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The ABO gene contains three major alleles that encodes different antigens; A, B, and O, which determine an individual's blood group. Previous studies have primarily focused on identifying associations between ABO blood groups and diseases risk. Here, we sought to test for association between ABO genotypes (OO, OA, AA; OB, BB, and AB) and a large set of common inflammatory and cardiovascular diseases in UK Biobank as well as disease‐related protein biomarkers in NSPHS. We first tested for association by conducting a likelihood ratio test, testing whether ABO contributed significantly to the risk for 24 diseases, and 438 plasma proteins. For phenotypes with FDR < 0.05, we tested for pair‐wise differences between genetically determined ABO genotypes using logistic or linear regression. Our study confirmed previous findings of a strong association between ABO and cardiovascular disease, identified associations for both type 1 and type 2 diabetes, and provide additional evidence of significant differences between heterozygous and homozygous allele carriers for pulmonary embolism, deep vein thrombosis, but also for von Willebrand factor levels. Furthermore, the results indicated an additive effect between genotypes, even between the two most common A subgroups, A1 and A2. Additionally, we found that ABO contributed significantly to 39 plasma proteins, of which 23 have never been linked to the ABO locus before. These results show the need of incorporating ABO genotype information in the consultation and management of patients at risk, rather than classifying patients into blood groups.

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Evidence of an association between the O blood group and allergic rhinitis

Cited by 14 publications

References 22 publications

Association of ABO blood groups with allergic diseases: a scoping review

Association of ABO blood groups with allergic diseases: a scoping review

ABO and RhD Blood Groups in Nasal Polyposis

Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank

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