Platelet indices

Giovanetti, Thayse Vanessa; Nascimento, Aguinaldo José do; Paula, Josiane Padilha de

doi:10.5581/1516-8484.20110040

Cited by 19 publications

(8 citation statements)

References 5 publications

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“…Studies have shown that the normal range of MPV should be established and calibrated within each specific laboratory due to the different laboratory analysis techniques [6], [18]. MPV changes are complex, and are not only related to the PLT count, but also related to the method of laboratory analysis used [19], [20].In a study by Akarsu et al, a MPV >9.5 fl was considered above normal range [15], and in another study, MPV elevation was defined >10.4 fl [7], both of which were commonly found in our study. The normal range of MPV from our laboratory was 9–17 fl, a range which is unsuitable for monitoring the evolution of septic shock.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Various Platelet Indices as Prognostic Markers of Septic Shock

et al. 2014

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IntroductionPlatelet indices, including mean platelet volume (MPV), are readily available blood tests, although their prognostic value in patients with septic shock has not been fully explored. Current evidence has found contradictory results. This study aims to explore the behavior of platelet indices in septic shock and their clinical prognostic value.MethodsCharts of septic shock patients from January to December 2012 in a tertiary medical center in Northern China were reviewed retrospectively. Platelet indices were recorded during the first five consecutive days after admission, as well as the penultimate and the last day of hospital stay. The data were compared between surviving and non-surviving patients.ResultsA total of 124 septic shock patients were enrolled. Thirty-six of the patients survived and 88 of them expired. MPV in the non-survivor group was higher than that of the survivor group, especially on the last day. PDW and PLCR showed increased trends, while PCT and PLT decreased in the non-survivor group. Among the PLT indices, MPV had the highest area under the receiver operating characteristic curve (0.81) with a precision rate of 75.6% at a cut-off of 10.5.Compared with other more usual septic shock prognostic markers, MPV is second only to lactate for the highest area under the curve.ConclusionA statistically significant difference was seen between survivors and non-survivors for platelet indices which make them easily available and useful prognostic markers for patients in septic shock.

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Section: Discussionmentioning

confidence: 99%

The Impact of Various Platelet Indices as Prognostic Markers of Septic Shock

et al. 2014

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“…It might then be worthwhile defining a local normal range with healthy volunteers across the entire age range. 16 , 25 , 29 , 35 …”

Section: Discussionmentioning

confidence: 99%

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Lök

Gülaçtı

Ekmekçi

et al. 2017

NSJ

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Objective:To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS).Methods:This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency department of a tertiary care hospital in Adiyaman, Turkey between January 2013 and June 2015. The data were evaluated according to whether alive or dead, MPV levels, modified Rankin scale (MRS) scores, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into 3 groups based on MPV level as 4.4-7.4 fL, 7.5-10.4 fL, higher than 10.4 fL.Results:A total of 250 patients with FEAIS were included in the study. In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05). The 3 MPV groups showed no significant differences in terms of MRS score, median NIHSS score, hospitalization, and TIV. In subgroups based on MRS scores, there were no statistically significant differences according to median latency (p=0.087), median hospitalization (p=0.394), TIV (p=0.201), and MPV levels (p=0.847). Furthermore, there were no differences in MPV levels between the MRS based groups (p=0.527).Conclusion:The results showed that MPV was not a significantly associated and reliable marker for the prediction of prognosis or functional outcome of FEAIS attack.

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“…Normal values of mean platelet volume (MPV) [ 5 ], platelet distribution width (PDW) [ 6 ], and plateletcrit (PCT) [ 7 ] were 7.4 to 10.4 fL, 10–17.9%, and 0.17 to 0.34%, respectively. Based on hemoglobin levels (as per WHO classification) [ 8 ] cases were classified into mild, moderate, and severe anemia in children <5 yrs and 5–18 yrs of age group.…”

Section: Methodsmentioning

confidence: 99%

Clinicohematological Study of Thrombocytosis in Children

et al. 2014

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Introduction. Primary thrombocytosis is very rare in children; reactive thrombocytosis is frequently observed in children with infections, anemia, and many other causes. Aims and Objectives. To identify the etiology of thrombocytosis in children and to analyze platelet indices (MPV, PDW, and PCT) in children with thrombocytosis. Study Design. A prospective observational study. Material and Methods. A total of 1000 patients with thrombocytosis (platelet > 400 × 109/L) were studied over a period of 2 years. Platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT) were noted. Results. Of 1000 patients, 99.8% had secondary thrombocytosis and only two children had primary thrombocytosis (chronic myeloid leukemia and acute myelogenous leukemia, M7). The majority of the children belonged to the age group of 1month to 2 years (39.7%) and male to female ratio was 1.6 : 1. Infection with anemia (48.3%) was the most common cause of secondary thrombocytosis followed by iron deficiency alone (17.2%) and infection alone (16.2%). Respiratory infection (28.3%) was the predominant infectious cause observed. Thrombocytosis was commonly associated with IDA among all causes of anemia and severity of thrombocytosis increased with severity of anemia (P = 0.021). With increasing platelet count, there was a decrease in MPV (<0.001). Platelet count and mean PDW among children with infection and anemia were significantly higher than those among children with infection alone and anemia alone. None were observed to have thromboembolic manifestations. Conclusions. Primary thrombocytosis is extremely rare in children than secondary thrombocytosis. Infections in association with anemia are most commonly associated with reactive thrombocytosis and severity of thrombocytosis increases with severity of anemia.

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Platelet indices

Cited by 19 publications

References 5 publications

The Impact of Various Platelet Indices as Prognostic Markers of Septic Shock

The Impact of Various Platelet Indices as Prognostic Markers of Septic Shock

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Clinicohematological Study of Thrombocytosis in Children

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