Efeito Da Salinomicina Na Prevenção Da Acidose Láctica Ruminal Experimental Em Ovinos

Câmara, Adaucides; Afonso, José Augusto Bastos; Mendonça, Carla Lopes de; Vieira, Aerlem Cynnara Silva

doi:10.5216/cab.v14i1.3792

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…However, Miranda Neto et al (2011), using sheep that underwent rumen lactic acidosis by administration of sucrose, observed that monensin was unable to control the ruminal pH in the animals, similar to the findings observed in this study, since the bicarbonate was unable to control the reduction of the ruminal pH. Salinomycin was also not effective in the prevention of acidosis by the administration of sucrose in sheep, but it minimized its adverse effects (Camara et al 2013).…”

Section: Discussionsupporting

confidence: 70%

Sodium bicarbonate as prevention of metabolic acidosis in sheep submitted to experimental ruminal acidosis

et al. 2014

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Pesq. Vet. Bras. 34(9):822-826, setembro 2014 822 RESUMO.-[Bicarbonato de sódio como preventivo da acidose metabólica em ovinos submetidos à acidose ruminal experimental.] O objetivo deste estudo foi avaliar o efeito preventivo do bicarbonato de sódio sobre a acidose sistêmica em decorrência da acidose ruminal, a qual foi induzida pelo fornecimento de concentrado após jejum prolongado. Foram utilizados 14 ovinos, divididos em três grupos experimentais: grupo controle (Cg), contendo quatro ovinos, submetidos a jejum sem desenvolvimento de acidose ruminal; grupo não tratado (NTg), contendo cinco ovinos submetidos a acidose ruminal sem tratamento preventivo; e grupo tratado (Tg), contendo cinco ovinos, submetidos a acidose ruminal e tratados preventivamente com bicarbonato de sódio. Foram realizadas avaliações do pH ruminal e hemogasometria arterial, durante 48 horas após o fornecimento do concentrado. Houve redução do pH ruminal em todos os grupos, sendo que o Cg apresentou a redução apenas às 24 horas. Notou-se redução do pH arterial, bicarbonato e excesso de base em todos os grupos, indicando acidose metabólica sistêmica; no entanto, o NTg apresentou o quadro mais grave. Conclui-se que o bicarbonato de sódio possui efeito preventivo da acidose metabólica sistêmica, reduzindo a sua gravidade em ovinos submetidos à acidose ruminal. The aim of this study was to evaluate the preventive effect of sodium bicarbonate on systemic acidosis due to ruminal acidosis, which was induced by ingestion of concentrate after prolonged fasting. Fourteen sheep were divided into three experimental groups: control group (Cg), with four sheep, submitted to fasting without development of ruminal acidosis; no-treated group (NTg), with five sheep with rumen acidosis without preventive treatment; and treated group (Tg), with five sheep with rumen acidosis and preventively treated with sodium bicarbonate. Assessments of ruminal pH and arterial hemogasometry were performed for 48 hours after ingestion of the concentrate. There was a reduction in the ruminal pH in all groups, whereas the Cg showed a reduction only after 24 hours. A reduction in the arterial pH, bicarbonate and base excess in all groups was also noted, indicating systemic metabolic acidosis, but the NTg presented the greatest alteration. It is concluded that sodium bicarbonate prevents systemic metabolic acidosis, reducing its severity in sheep subjected to ruminal acidosis.INDEX TERMS: Sodium bicarbonate, lactic ruminal acidosis, systemic metabolic acidosis, buffering, hemogasometry, sheep.

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Section: Discussionsupporting

confidence: 70%

Sodium bicarbonate as prevention of metabolic acidosis in sheep submitted to experimental ruminal acidosis

et al. 2014

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“…This procedure may have promoted acidosis by arresting microorganism growth, with a resultant decrease in and loss of microorganism diversity (Mackie et al 2002). Protocols for the experimental induction of ALRA in sheep , Câmara et al 2013), goats (Miranda Neto et al 2005, Miranda Neto et al 2011, and cattle (Ortolani 1995, Thoefner et al 2004, Nagaraja & Titgemeyer 2007 include fasting to enlarge the ruminal space before substrate administration, despite differences in only substrate type and dose. These protocols also require exclusive feeding on forage or diets with low levels of concentrate before the induction of acidosis to prevent increases in the population of lactate-using bacteria (Ortolani 1995, Thoefner et al 2004, Nagaraja & Titgemeyer 2007, Danscher et al 2009.…”

Section: Discussionmentioning

confidence: 99%

Experimental poisoning by Enterolobium contortisiliquum in sheep

et al. 2017

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Ingestion of Enterolobium contortisiliquum pods causes digestive disturbances, secondary hepatogenous photosensitization and abortions in ruminants. Pods were administered to sheep via a ruminal cannula to characterize acute poisoning. In Experiment 1, a single dose of 12g/kg of body weight (BW) was administered to three sheep in one experiment. One sheep died, and the other two recovered after presenting clinical signs. In Experiment 2, 10g/kg BW were administered daily to 15 sheep until the onset of clinical signs or for three consecutive days. Fourteen sheep showed mild to severe signs after the ingestion of 1-3 doses. Two sheep died, and the others recovered. Clinical signs in both experiments were diarrhea, anorexia, rumen atony, apathy, dehydration and tachypnea. The main macroscopic findings were an orange, frothy ruminal content witch contained pods fragments. The intestinal content was liquid. Detachment of the mucosa from the submucosa and ballooning degeneration of mucosal cells were observed histologically in the forestomachs. Evaluation of ruminal contents revealed acute lactic ruminal acidosis (ALRA). Bromatological analysis of E. contortisiliquum pods revealed 537.8g/kg DM (dry matter) of non-fibrous carbohydrates, which is sufficient to cause ALRA. Only one sheep in Experiment 2 had liver failure, characterized by jaundice, elevated serum activity of liver enzymes and histological lesions in liver biopsies. It is concluded that the administration of E. contortisiliquum pods in forage--fed sheep at doses of 10g/kg BW or higher may cause ALRA. The induction of liver failure in one sheep suggests that liver damage may occur in those sheep that do not develop acidosis.

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“…A observação dos sinais clínicos, análise do fluído ruminal e urina, quando associados ao conhecimento das alterações sanguíneas permitem melhor avaliação do quadro clínico e direcionamento apropriado da terapêutica (PATRA et al, 1993;NIKOLOV, 2003;CÂMARA, 2008). No entanto, devido aos prejuízos que acarreta, o mais racional é evitar que a enfermidade aconteça (VIEIRA et al, 2006).…”

Section: Introductionunclassified

Perfil Hematológico E Bioquímico De Ovinos Suplementados Com Salinomicina Submetidos À Acidose Láctica Ruminal

Vieira

Câmara

Afonso³

et al. 2012

Ci. Anim. Bras.

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Utilizaram-se 12 ovinos distribuídos nos grupos controle (GC) e no salinomicina (GS) com objetivo de estudar alterações clínicas, hematológicas e bioquímicas nos ovinos suplementados com o ionóforo e avaliar seu efeito na prevenção da acidose ruminal experimental. Induziu-se acidose ruminal com sacarose e as variáveis foram analisadas 4h, 8h, 12h, 16h, 24h, 32h e 48h pós-indução (PI). Determinaram-se as enzimas AST, GGT, FA, CK, as proteínas totais séricas (PT), albumina, ureia, creatinina, hemograma, proteína plasmática total (PPT), fibrinogênio (FP), glicose e L-lactato. Manifestações clínicas de acidose láctica ruminal e os menores valores de pH foram observadas 8h PI, com (P<0,05) no GS comparado ao momento 0h. Os neutrófilos apresentaram maiores contagens (P<0,05) no GC 4h PI comparado ao GS. O FP alcançou maiores valores (P<0,05) no GC 48h PI comparado ao GS. A uréia diminuiu (P<0,05) em ambos os grupos 12h PI. A glicose aumentou (P<0,05) no GC comparado ao momento 0h. Houve queda (P<0,05) do pH urinário no momento 12h até 48h PI, em relação ao momento 0h no GC, enquanto no GS apenas os momentos 12h e 16h PI apresentaram diminuição (P<0,05). A salinomicina não preveniu a acidose; no entanto, favoreceu o restabelecimento dos animais tratados.

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Efeito Da Salinomicina Na Prevenção Da Acidose Láctica Ruminal Experimental Em Ovinos

Cited by 3 publications

References 24 publications

Sodium bicarbonate as prevention of metabolic acidosis in sheep submitted to experimental ruminal acidosis

Sodium bicarbonate as prevention of metabolic acidosis in sheep submitted to experimental ruminal acidosis

Experimental poisoning by Enterolobium contortisiliquum in sheep

Perfil Hematológico E Bioquímico De Ovinos Suplementados Com Salinomicina Submetidos À Acidose Láctica Ruminal

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