Synthesis, characterization and biological activity study of some new palladium(II) complexes containing amine or azomethine groups

Al-Fregi, Adil A.; Al-Fadhly, Ahmed L.; Al-Salami, Bushra K

doi:10.5155/eurjchem.8.2.155-161.1564

Cited by 2 publications

(3 citation statements)

References 24 publications

(29 reference statements)

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“…Also, Z5A11' compound showed more potent compared to the positive control (IZ= 0-25) mm at the same concentration. From the other hand, Our data pointed out that compound Z5A2' showed a good antibacterial activity against Gm+Ve (Bacillus) with an IZ ranging from (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) tetracycline (IZ = 11-30 mm) at the concentrations (5-250)mg/mL. The antimicrobial activity of these new synthetic heterocyclic compounds is may attributed to the basis of their structures, mainly possessing the phenolic-OH group.…”

Section: Antibacterial Activitymentioning

confidence: 92%

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Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide

et al. 2021

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Several new and know sulfonamide Schiff bases were prepared by the condensation reaction of sulfonamide (i.e.2-amino-4chlorobenzenesulfonamide, sulfamerazine, sulfanilamide, sulfamethazine, sulfathiazole and sulfadiazine) with vanillin and salicylaldehyde, respectively in an acidic medium. These Schiff bases were used to a new series of β-lactam (azetidin-2-one) compounds (i.e. 4-chloro-2-(2-(4-hydroxy-3-methoxyphenyl)-3-mercapto-4-oxoazetidin-1-yl)benzenesulfonamide , 4-[2-aryl-3-mercapto (or 3-hydroseleno)-4-oxoazetidin-1-yl]-N-substituted benzenesulfonamide; Z5A1-Z5A6, Z5A9-Z5A12, Z5A2', Z5A9'-Z5A11') by their reactions with thioglycolic acid and 2-seleno-glycolic acid, respectively, in presences of phosphorus oxychloride and triethylamine. Cyclocondensation of the Schiff bases with 2-mercaptobutanoic acid in presence of zinc chloride afforded 4-thiazolidinone derivatives (i.e. 4-[5-ethyl-2-aryl-4-oxothiazolidin-3-yl]-N-substituted benzenesulfonamide; ZZ5A2-ZZ5A6, ZZ5A9-ZZ5A12). All new azetidin-2-one and 1,3-thiazolidin-4-onederivatives were characterized by IR, 1 H NMR, 13 C NMR, mass spectroscopic techniques and elemental analysis. The toxicity of new compounds was assayed via the determination of their LD50 value by using Dixon ' s up and down method. The antibacterial activity of azetidin-2-onecompounds were tested in vitro against Staphylococcus aureus, Bacillus, Escherichia coli and Pseudomonas aeruginosa. Furthermore, the antioxidant and anticancer efficiency of compounds were evaluated.

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Section: Antibacterial Activitymentioning

confidence: 92%

“…[24] Furthermore, values of minimum inhibitory concentration (MIC) of those compounds. [25] The MIC was recorded because the lowest concentration at which no visible growth was observed.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide

et al. 2021

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“…The spectrum also shows a series of peaks corresponding to the various fragments of the compound. The intensities of the peaks give an idea of the relative stability of the fragments [20][21][22]. The IR spectral data of the ligand shows strong band at ν 3455 cm -1 which is assigned to stretching mode of carboxylic acid group (COOH).…”

Section: Spectral Studiesmentioning

confidence: 99%

Synthesis, characterization and biological activity of a Schiff base derived from o-amino benzoic acid and its Co(II), Cd(II) and Ni(II) complexes

et al. 2020

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Equimolar amounts of imidazoleacetophenone and 2-aminobenzoic acid were combined together and the Schiff base 4(1H-imidazole-yl)acetophenoneanthranilic acid was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with cobalt(II), cadmium(II), and nickel(II) ions yielding air stable complexes. For quantification and characterization purposes, elemental analysis, infrared spectra, electronic spectra, proton nuclear magnetic resonance spectra and mass spectra studies were carried out on the obtained complexes and ligand. Thermogravimetric analysis and magnetic susceptibility measurements were also used for characterization. The ligand IR spectrum showed that the ligand acts as a bidentate coordinates to the metal ions through the nitrogen and oxygen atoms.Measurements of magnetic susceptibility for Ni(II) and Co(II) complexes were found to be 3.4 and 3.8 B.M., respectively, in the range normal for the octahedral geometry. The conductivity measurements revealed that the chelates are non-electrolytes. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against a number of bacterial and fungal strains, to assess their antimicrobial properties by diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.

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Synthesis, characterization and biological activity study of some new palladium(II) complexes containing amine or azomethine groups

Cited by 2 publications

References 24 publications

Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide

Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide

Synthesis, characterization and biological activity of a Schiff base derived from o-amino benzoic acid and its Co(II), Cd(II) and Ni(II) complexes

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