2013
DOI: 10.5155/eurjchem.4.2.98-101.714
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Abstract: KEYWORDSSeveral 2-azetidinones 2a-e and 4-thiazolidinones 3a-e have been synthesized from halosubstituted Schiff bases using conventional as well as microwave technique. The newly synthesized compounds were established on the basis of spectroscopic technique. Further, all compounds screened for antimicrobial activity against Bacillus subtilis, Escherichia coli, Aspergillus niger and Aspergillus flavus. Most of the titled compounds show potent activity.

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Cited by 6 publications
(2 citation statements)
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“…1) which are used as broad spectrum antibacterial agents. A large number of 3-chloro monocyclic β-lactam exhibits powerful antimicrobial, anticonvulsant, anti-inflammatory and antitubercular activities [23][24][25]. Conventional synthesis of 3-chloro-2-azetidinones involves [2 + 2] Staudinger's ketene-imine cycloaddition reaction between chloroacetyl chloride and Schiff bases [26].…”
Section: Introductionmentioning
confidence: 99%
“…1) which are used as broad spectrum antibacterial agents. A large number of 3-chloro monocyclic β-lactam exhibits powerful antimicrobial, anticonvulsant, anti-inflammatory and antitubercular activities [23][24][25]. Conventional synthesis of 3-chloro-2-azetidinones involves [2 + 2] Staudinger's ketene-imine cycloaddition reaction between chloroacetyl chloride and Schiff bases [26].…”
Section: Introductionmentioning
confidence: 99%
“…And finally, if morpholine subunit gets attached to a lipophillic scaffold it increases its bioavailability through oral administration by increasing aqueous solubility [15][16][17][18]. Likewise the chemistry of thiazolidine ring system is of considerable interest as it forms core structure of many biomolecules, commercial drugs [19]and synthetic molecules with promising antimicrobial, antifungal, anticancer and antidiabetic activity [20][21][22][23][24][25][26][27][28]. Combining multiple bioactive structural moieties into a single molecule usually complements the overall pharmacophoric performance and has been extensively used to design new drug candidates in structure based drug design [29,30].…”
Section: Introductionmentioning
confidence: 99%