Synthesis of some novel Schiff bases containing 1,2,4-triazole ring

Abstract

KEYWORDS4-Allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol was prepared under facile condition via the formation of 2-isonicotinoyl-N-allylhydrazinecarbothioamide. In addition, ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate was synthesized via the reaction of 4-allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol with ethyl chloroacetate. 2-[(4-Allyl-5-pyridine-4-yl-4H-1,2,4-triazole-3-yl)thio]acetohydrazide obtained by using ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate as a precursor by two steps, was converted to Schiff base derivatives, 6a-j. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, 1 H NMR and 13 C NMR spectroscopy. The cis/trans conformers of E isomer were present in DMSO solution of compounds 6a-j.

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

“…Prompted by these observations and as a continuation of our research program on the synthesis of 1,2,4-triazole derivatives [17][18][19][20][21], herein we wish to disclose synthesis of some novel five memberd heterocycle derivatives via intramolecular cyclization reactions in good yield.…”

Design, Synthesis, and Antitumor Activity of Novel 5-Pyridyl-1,3,4-oxadiazole Derivatives against the Breast Cancer Cell Line MCF-7

“…24) In the present study, the spectral data were recorded in DMSO-d 6 , and the signal corresponding to the imine hydrogen was observed in the range of δ 7.95-8.55 ppm. 2 , N=CH and -NH protons were assigned to cis-conformer of the amide structure and downfield signals of the same group to trans-conformer of the amide structure.…”

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“…Then, the solvent was evaporated to give the solid product. The crude product was recrystallized from H 2 O:C 2 H 5 OH (1:1) 26 .…”