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Abstract

Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of Antimicrobial Activity. The extreme efforts have been developed to design novel series of Schiff 's bases with triazole ring (8a and 8b) have been synthesized from 4-Amino-5-((4-amino-5-phenyl-4H-1,2,4-Triazol-3-ylthio)methyl)-4H-1,2,4-Triazole-3-thiol (7), which is built by multiple consecutive cyclization reactions starting from benzoic acid hydrazide (1). Infrared spectroscopy and melting points were used to characterize the synthesized compounds. The biological activity of compounds (7) and (8a and 8b) were evaluated toward gram negative bacteria (Escherichia coli) and gram positive bacteria (staphylococcus aureus).