Associations between Gilbert´s syndrome and personality characteristics

Düzenli, Tolga; Maden, Özgür; Tanoğlu, Alpaslan; Kaplan, Mustafa; Yazgan, Yusuf

doi:10.47626/2237-6089-2020-0003

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Moreover, TB concentrations >1.75 mg/dL for women and >2.34 mg/dL for men were also excluded from analysis for excluding population with Gilbert syndrome, known as a benign hereditary disease with indirect hyperbilirubinemia caused by the common UGT1A1 genotypes. 15 This study was performed in line with the principles of the Declaration of Helsinki. Written informed consent was attained from all the participants.…”

Section: Methodsmentioning

confidence: 99%

Association Between Serum Total Bilirubin and COPD: Results from a Cross-Sectional Study and a Bidirectional Mendelian Randomization Analysis

Dai¹,

Wang²,

Yang³

et al. 2022

CLEP

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Background The potential protective role of serum total bilirubin (TB) for chronic obstructive pulmonary disease (COPD) is controversial. We aimed to investigate whether serum TB could prevent airflow limitation (reduce the risk of COPD) and whether these associations were causal or reversely causal. Methods We conducted a multi-center and cross-sectional study including 3069 participants. Logistic regression model (LRM) with restricted cubic spline (RCS) and priori defined quintile categories were used to assess the associations of TB with COPD. Besides, ordinary least squares (OLS) regression model with RCS curves were applied to assess the dose-response relationship between serum TB and airflow limitation (FEV 1 /FVC). To verify the causal direction between TB and COPD, a bidirectional Mendelian randomization analysis was carried out with GWAS data from European ancestry. Results In the cross-sectional study, the relationship between levels of TB and COPD risk was U shaped (P=0.001), and the low and high concentrations of TB apparently increasing the risk of COPD (OR 1.40, 95% CI 1.07 to 1.82 for less than 9 μmol/L; OR 1.36, 95% CI 1.06 to 1.76 for 9.01–1 0.88 μmol/L; OR 1.50, 95% CI 1.16 to 1.95 for more than 13 μmol/L). There was a significant non-linear relationship between TB and FEV 1 /FVC (non-linear p=0.004). Furthermore, results of bidirectional Mendelian randomization analysis (OR 1.000; 95% CI 0.983 to 1.017 for MR and OR 0.998; 95% CI 0.976 to 1.020 for reversal MR) did not support the causal effects between serum TB and FEV 1 /FVC after controlling the effect of potential confounders and revised causality. Conclusion Our study reveals that there was non-linear does-response pattern between serum TB and COPD. However, there was little evidence for the linear causal associations of serum TB with airflow limitation. The relationship of TB with COPD needs further study and careful interpretation.

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Section: Methodsmentioning

confidence: 99%

Association Between Serum Total Bilirubin and COPD: Results from a Cross-Sectional Study and a Bidirectional Mendelian Randomization Analysis

Dai¹,

Wang²,

Yang³

et al. 2022

CLEP

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show abstract

“…Additionally, TB concentrations >1.75 mg/dL for women and >2.34 mg/dL for men were also excluded for suspicious Gilbert syndrome, a benign hereditary disease caused by UGT1A1 genotypes. 18 The original two studies were performed in line with the principles of the Declaration of Helsinki. Besides, the two studies were approved by the Ethics Committee of Scientific research project review of the First Hospital of Guangzhou Medical University (No.2013–37 for 2012–2015 Program and N0.2018–53 for ECOPD) and written informed consent was also attained from all the participants.…”

Section: Methodsmentioning

confidence: 99%

Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study

Dai¹,

Wang²,

Deng³

et al. 2022

COPD

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Background Serum total bilirubin has been reported to have antioxidant properties against chronic respiratory diseases. The objective of our study is to evaluate the association of total bilirubin (TB) with annual lung function decline in COPD patients with different GOLD stages. Methods This study used pooled data from two observational and prospective cohorts of 612 COPD patients whose TB levels were measured at baseline. The associations between TB and postbronchodilator FEV 1 , FEV 1 pred, FVC, FVCpred, FEV 1 /FVC, and the rate of their decline were all determined using linear regression models in the total population and strata of GOLD stages. Results Serum TB was positively related to FEV 1 and FVC in the total group (β 0.02, 95% CI 0.001~0.02, P = 0.025 and β 0.02, 95% CI 0.002~0.03, P = 0.022, respectively). Additionally, TB was inversely associated with the annual decline in FEV 1 and FEV 1 pred (β 4.91, 95% CI 1.68~8.14, P = 0.025 and β 0.21, 95% CI 0.06~0.36, P = 0.022, respectively) when adjusted for multivariables. After stratification, the significant associations merely persisted in COPD patients with GOLD 2 and GOLD 3–4. Conclusion Increased TB level was related to less annual decline in FEV 1 as well as FEV 1 pred in moderate-to-severe COPD but not mild COPD, which indicated the different status of TB in different COPD severity and the possible role as potential biomarker merely in moderate-to-severe COPD. Future researches to determine whether TB could be served as biomarker for COPD and the mechanisms should be focused on some target patients with a certain disease severity.

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Modern view on pathogenesis, diagnosis and treatment of Gilbert's syndrome

Левитан

Скворцов

Morozov

et al. 2023

Medicinskij alfavit

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Gilbert’s syndrome is an autosomal recessive inherited disorder of bilirubin glucuronidation characterized by unconjugated hyperbilirubinaemia in the absence of hepatocellular injury or hemolysis. Gilbert’s syndrome is characterized by mutations to the UGT1A1 gene which encodes the enzyme uridine disphosphate glucuronоsyltransferase which is required for the conjugation and subsequent excretion of bilirubin. Most Gilbert’s syndrome patients experience recurrent and short-term episodes of yellowing of the skin and sclera of eyes caused by bilirubin accumulation in the blood. Approximately 30 % of patients with Gilbert's syndrome do not experience any symptoms, but are detected by blood tests that show elevated levels of unconjugated bilirubin. In addition to traditional methods, genetic analysis of the UGT1A1 gene allows us to confirm the diagnosis of Gilbert's syndrome. The article presents modern concepts of the pathogenesis, diagnosis, differential diagnosis and treatment of Gilbert's syndrome. It is of interest to gastroenterologists, internists and general practitioners who treat such patients.

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Associations between Gilbert´s syndrome and personality characteristics

Cited by 3 publications

References 20 publications

Association Between Serum Total Bilirubin and COPD: Results from a Cross-Sectional Study and a Bidirectional Mendelian Randomization Analysis

Association Between Serum Total Bilirubin and COPD: Results from a Cross-Sectional Study and a Bidirectional Mendelian Randomization Analysis

Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study

Modern view on pathogenesis, diagnosis and treatment of Gilbert's syndrome

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