Evaluation of the Short-Term Efficacy of Transdermal Ozone Therapy in Turkish Patients with Internal Derangement of the Temporomandibular Joint

Abstract

To investigate the efficacy of transdermal high-frequency ozone therapy in the management of pain and pain-related restricted jaw movements in patients with internal derangement of the temporomandibular joint (TMJ). Material and Methods: This retrospective study included 40 patients who had received transdermal high-frequency ozone therapy for the management of disc displacement with reduction of the TMJ. Subjects were treated 3 times for one week with a bio-oxidative high-frequency ozone generator with an intensity of 80% for ten minutes bilaterally. Pain scores and maximal interincisal opening (MIO) values of the patients were evaluated before and after the treatment. Results: An increase in the mean MIO value was achieved following the ozone therapy, however, the difference was not statistically significant (p=0.350). A statistically significant decrease in the mean pain score (48.13 ± 27.75) was observed following the ozone therapy. Conclusion: Transdermal application of high frequency ozone may be a good alternative for management of pain and pain-related restricted jaw movements in patients with internal derangement of the TMJ.

Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

“…Main clinical symptoms are pain and limited jaw range of motion, often accompanied by decrease in the maximal interincisal opening, muscle or joint tenderness on palpation, joint sounds, and otologic complaints (e.g., tinnitus, vertigo, or ear fullness) [ 151 , 152 ]. These signs and symptoms could lead to discomfort or difficulty in performing activities of daily living, such as eating, chewing, talking, swallowing, yawning, causing disability with a significantly reduced quality of life [ 153 , 154 , 155 ].…”

“…Several conservative treatments have been used for reducing TMD-related pain, including occlusal splint devices [ 168 , 169 ], behavioral therapies [ 170 ], manual therapy [ 171 ], laser therapy [ 172 ], transcutaneous electrical nerve stimulation (TENS) [ 173 ], dry needling [ 173 ]. In this context, O 2 O 3 therapy [ 152 , 174 , 175 , 176 ] might be considered as a promising new treatment to reduce TMD pain, although the mechanism of action should still be adequately investigated [ 177 ]. Probably, O 2 O 3 might effectively decrease inflammation with a down-regulation of pro-inflammatory cytokines and an up-regulation of IL-10 anti-inflammatory cytokine [ 123 ].…”

Effectiveness of ozone injection therapy in temporomandibular disorders

“…Özalp et al . [ 20 ] in 2019 in an intervention study treated 40 patients with TMD with ozone therapy with high frequency of ozone. Patients were treated bilaterally three times a week with an ozone generator with high frequency of ozone with intensity of 80% for 10 min.…”

“…However, the average pain score decrease in the patients treated with ozone therapy was statistically significant. [ 20 ]…”

Ozone for the treatment of temporomandibular joint disorders: a systematic review and meta-analysis

“… 29 This could explain the heterogeneity of the effect of the intervention found across the studies included in the meta-analysis. On the other hand, two studies had the best available therapy (occlusal splint 18 or pharmacological therapy 30 ) as a control group, which could provide information about potential side effects. 31 Unfortunately, the follow-up in the included studies was heterogeneous and short (1 week 16 or 1 month 19 ), and none of the studies aimed to report side effects.…”