There have been generalized the study results of the parameters of ecological adaptability of winter durum wheat and there have been identified the most adaptive varieties of different ecology under unstable climatic conditions of the Rostov region. There was conducted the analysis of 34 varieties of domestic and foreign breeding, which have been recommended for cultivation in different climatic zones. During the current study there have been identified the groups of winter durum wheat varieties that were different in their ecological adaptability parameters. The first group included 11 highly responsive varieties recommended for cultivation on an intensive background, namely ‘Alyy parus’, ‘Kontinent’, ‘Laguna’, ‘Kassiopeya’, ‘Akveduk’ (Ukraine), ‘Prikumskaya 142’, ‘Eyrena’, ‘Kiprida’, ‘Terra’, ‘Oniks’, ‘Kurant’ (Russia). To obtain the largest average productivity there have been recommended to cultivate the following 11 varieties on the average agricultural background, namely ‘Aksinit’, ‘Amazonka’, ‘Kermen’, ‘Uniya’, ‘Diona’, ‘Yakhont’, ‘Yubilyarka’, ‘Belgorodskaya yantarnaya’ (Russia), ‘Zolotoye runo’, ‘Gardemarin’, ‘Andromeda’ (Ukraine), since these varieties were good adapted to various environmental conditions. The varieties ‘Agat donskoy’,‘Zolotko’,‘Krupinka’, ‘Laska’, ‘Lazurit’, ‘Krucha’, ‘Stepnoy yantar’ (Russia), ‘Burshtin’, ‘Dnepryana’, ‘Perlina odesskaya’ and ‘Shulyndinka’ (Ukraine) -to cultivate on a reduced agrofone, where they will give a fairly high yield from 8.45 to 9.67 t / ha.