Vascular Aging and Arterial Stiffness in Older Adults

Campana, Érika Maria Gonçalves; Inuzuka, Sayuri

doi:10.36660/ijcs.20200132

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…7 It is known to be a risk factor of cardiovascular disease and when coupled with arterial stiffness, potentiates this risk. 8,9 The association between frailty and arterial stiffness is well known. 8,10 In a crosssectional study involving 2171 community-dwelling participants aged 60 years and over, arterial stiffness was noted to be strongly associated with pre-frail and frail status.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 The association between frailty and arterial stiffness is well known. 8,10 In a crosssectional study involving 2171 community-dwelling participants aged 60 years and over, arterial stiffness was noted to be strongly associated with pre-frail and frail status. 11 Although this association exists, arterial stiffness does not uniformly correlates with the various stages of frailty [12][13][14] though it is considered to be the hall mark of vascular ageing.…”

Section: Introductionmentioning

confidence: 99%

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1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

et al. 2023

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Introduction There is an association between frailty and arterial stiffness. However, arterial stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress and inflammaging contribute to vascular aging. There are no human studies exploring links between arterial stiffness, oxidative stress, inflammaging and frailty. Our objective is to investigate arterial stiffness and inflammaging as predictors of frailty states. Methods An observational longitudinal cohort study will be used to examine the association between arterial stiffness, oxidative stress, and inflammation in 50 older adults (≥70 years) with clinical frailty scores (CFS) ≤6 over six months. All study measurements will be taken at baseline. Frailty assessment will include hand-grip strength, timed-up and go test, mini-mental state examination, geriatric depression scale and sarcopenia using body composition measurements with Tanita®. Arterial stiffness measurements will include carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) using Complior (Alam Medical, France). CAVI device will measure Cardio-ankle vascular index and ankle brachial index (ABI). Oxidative stress blood markers nitrotyrosine (NT) and 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) and inflammation markers high-sensitive C-reactive protein (hs-CRP) and interlukin-6(IL-6) will be measured at baseline and 6-months along with lipid profile and glycated haemoglobin. Data Analysis Descriptive statistics for continuous data using means and standard deviations for normality distributed variables or medians and inter-quartile ranges for skewed variables will be used. Participants will be categorised into CFS 1-3, and CFS 4-6. Categorical data will use frequencies and comparison between groups. Change in frailty between the groups over 6 months will be compared using paired t-test. Simple linear regression will be done between frailty measures, arterial stiffness, inflammation, and oxidative stress biomarkers. Significance will be at p<0.5. Conclusion This study data will inform a larger, multi-centre study exploring further the interplay between frailty, biomarkers, and arterial stiffness parameters. This study is funded by BGS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

et al. 2023

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“… 7 It is known to be a risk factor of cardiovascular disease and when coupled with arterial stiffness, potentiates this risk. 8 , 9 The association between frailty and arterial stiffness is well known. 8 , 10 In a cross-sectional study involving 2171 community-dwelling participants aged 60 years and over, arterial stiffness was noted to be strongly associated with pre-frail and frail status.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 The association between frailty and arterial stiffness is well known. 8 , 10 In a cross-sectional study involving 2171 community-dwelling participants aged 60 years and over, arterial stiffness was noted to be strongly associated with pre-frail and frail status. 11 Although this association exists, arterial stiffness does not uniformly correlates with the various stages of frailty 12 - 14 though it is considered to be the hall mark of vascular ageing.…”

Section: Introductionmentioning

confidence: 99%

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FRailty and Arterial stiffness – the role of oXidative stress and Inflammation (FRAXI study)

et al. 2022

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Objective: There is an association between frailty and arterial stiffness. However, arterial stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress and inflammaging contribute to vascular ageing. There are no human studies exploring links between arterial stiffness, oxidative stress, inflammaging and frailty. Our objective is to investigate arterial stiffness and inflammaging as predictors of frailty states. Methods: An observational longitudinal cohort study will be used to examine the association between arterial stiffness, oxidative stress and inflammation in 50 older adults (⩾70 years) with clinical frailty scores (CFS) ⩽6 over 6 months. All study measurements will be taken at baseline. Frailty assessment will include hand-grip strength, timed-up and go test, mini-mental state examination, geriatric depression scale and sarcopenia using body composition measurements with Tanita®. Arterial stiffness measurements will include carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) using Complior (Alam Medical, France). CAVI device will measure Cardio-ankle vascular index and ankle brachial index (ABI). Oxidative stress blood markers nitrotyrosine (NT) and 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) and inflammation markers high-sensitive C-reactive protein (hs-CRP) and interlukin-6(IL-6) will be measured at baseline and 6 month along with lipid profile and glycated haemoglobin. Results (data analysis plan): Descriptive statistics for continuous data using means and standard deviations for normality distributed variables or medians and inter-quartile ranges for skewed variables will be used. Participants will be categorised into CFS 1-3, and CFS 4-6. Categorical data will use frequencies and comparison between groups. Change in frailty between the groups over 6 months will be compared using paired t-test. Simple linear regression will be done between frailty measures, arterial stiffness, inflammation and oxidative stress biomarkers. Significance will be at P < .05. Conclusion: This study data will inform a larger, multi-centre study exploring further the interplay between frailty, biomarkers and arterial stiffness parameters.

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Vascular Function and Frailty in Community-Dwelling Older Individuals

et al. 2022

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Background Frailty is a condition characterized by a state of reduced physiological reserve and increased vulnerability to stressors. Frail individuals have a higher likelihood of developing cardiovascular disease (CVD). However, the mechanisms underlying the association between frailty and CVD remain unclear. Objectives This study investigated whether frailty is associated with vascular function in community-dwelling older individuals. Material and Methods We conducted a cross-sectional analysis of 92 community-dwelling individuals aged ≥ 65 years, including 30 non-frail, 43 pre-frail, 19 frail individuals. Vascular function was assessed by brachial-ankle pulse wave velocity (PWV, measuring arterial stiffness) and flow-mediated dilation of the brachial artery (FMD, measuring endothelial function). Results The PWV was significantly higher in both pre-frail and frail groups than in the non-frail group (non-frail: 1615.7 ± 209.9 cm/s vs. pre-frail: 1815.2 ± 265.0 cm/s vs. frail: 1829.9 ± 256.0 cm/s, respectively, p = 0.003). The FMD was significantly lower in both pre-frail and frail groups than in the non-frail group (non-frail: 5.1 ± 2.1% vs. pre-frail: 3.4 ± 1.3% vs. frail: 3.1 ± 1.2% cm/s, respectively, p = 0.001). Multiple logistic regression analyses indicated that pre-frail and frail group were associated with arterial stiffness (OR, 2.92; 95% CI, 1.01–8.42; OR, 3.56; 95% CI, 0.85–14.91) and endothelial dysfunction (OR, 2.17; 95% CI, 0.41–3.09; OR, 2.27; 95% CI, 0.31–6.97). Conclusions Thus, pre-frailty and frailty are associated with impaired vascular function in community-dwelling older adults, even when adjusting for confounding factors. These findings may help to prevent the potential consequences between CVD and frailty in community-dwelling older individuals.

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Vascular Aging and Arterial Stiffness in Older Adults

Cited by 3 publications

References 8 publications

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

FRailty and Arterial stiffness – the role of oXidative stress and Inflammation (FRAXI study)

Vascular Function and Frailty in Community-Dwelling Older Individuals

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