Determinants of Arterial Stiffness and Vascular Aging in the Older Adult

Pereira, Telmo; Costa, Tommaso

doi:10.36660/ijcs.20190068

Cited by 5 publications

(6 citation statements)

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“…7 It is known to be a risk factor of cardiovascular disease and when coupled with arterial stiffness, potentiates this risk. 8,9 The association between frailty and arterial stiffness is well known. 8,10 In a crosssectional study involving 2171 community-dwelling participants aged 60 years and over, arterial stiffness was noted to be strongly associated with pre-frail and frail status.…”

Section: Introductionmentioning

confidence: 99%

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

et al. 2023

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Introduction There is an association between frailty and arterial stiffness. However, arterial stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress and inflammaging contribute to vascular aging. There are no human studies exploring links between arterial stiffness, oxidative stress, inflammaging and frailty. Our objective is to investigate arterial stiffness and inflammaging as predictors of frailty states. Methods An observational longitudinal cohort study will be used to examine the association between arterial stiffness, oxidative stress, and inflammation in 50 older adults (≥70 years) with clinical frailty scores (CFS) ≤6 over six months. All study measurements will be taken at baseline. Frailty assessment will include hand-grip strength, timed-up and go test, mini-mental state examination, geriatric depression scale and sarcopenia using body composition measurements with Tanita®. Arterial stiffness measurements will include carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) using Complior (Alam Medical, France). CAVI device will measure Cardio-ankle vascular index and ankle brachial index (ABI). Oxidative stress blood markers nitrotyrosine (NT) and 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) and inflammation markers high-sensitive C-reactive protein (hs-CRP) and interlukin-6(IL-6) will be measured at baseline and 6-months along with lipid profile and glycated haemoglobin. Data Analysis Descriptive statistics for continuous data using means and standard deviations for normality distributed variables or medians and inter-quartile ranges for skewed variables will be used. Participants will be categorised into CFS 1-3, and CFS 4-6. Categorical data will use frequencies and comparison between groups. Change in frailty between the groups over 6 months will be compared using paired t-test. Simple linear regression will be done between frailty measures, arterial stiffness, inflammation, and oxidative stress biomarkers. Significance will be at p<0.5. Conclusion This study data will inform a larger, multi-centre study exploring further the interplay between frailty, biomarkers, and arterial stiffness parameters. This study is funded by BGS.

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Section: Introductionmentioning

confidence: 99%

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

et al. 2023

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“… 7 It is known to be a risk factor of cardiovascular disease and when coupled with arterial stiffness, potentiates this risk. 8 , 9 The association between frailty and arterial stiffness is well known. 8 , 10 In a cross-sectional study involving 2171 community-dwelling participants aged 60 years and over, arterial stiffness was noted to be strongly associated with pre-frail and frail status.…”

Section: Introductionmentioning

confidence: 99%

FRailty and Arterial stiffness – the role of oXidative stress and Inflammation (FRAXI study)

et al. 2022

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Objective: There is an association between frailty and arterial stiffness. However, arterial stiffness does not uniformly correlate with the spectrum of frailty states. Both oxidative stress and inflammaging contribute to vascular ageing. There are no human studies exploring links between arterial stiffness, oxidative stress, inflammaging and frailty. Our objective is to investigate arterial stiffness and inflammaging as predictors of frailty states. Methods: An observational longitudinal cohort study will be used to examine the association between arterial stiffness, oxidative stress and inflammation in 50 older adults (⩾70 years) with clinical frailty scores (CFS) ⩽6 over 6 months. All study measurements will be taken at baseline. Frailty assessment will include hand-grip strength, timed-up and go test, mini-mental state examination, geriatric depression scale and sarcopenia using body composition measurements with Tanita®. Arterial stiffness measurements will include carotid-femoral pulse wave velocity (cfPWV) and carotid-radial pulse wave velocity (crPWV) using Complior (Alam Medical, France). CAVI device will measure Cardio-ankle vascular index and ankle brachial index (ABI). Oxidative stress blood markers nitrotyrosine (NT) and 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) and inflammation markers high-sensitive C-reactive protein (hs-CRP) and interlukin-6(IL-6) will be measured at baseline and 6 month along with lipid profile and glycated haemoglobin. Results (data analysis plan): Descriptive statistics for continuous data using means and standard deviations for normality distributed variables or medians and inter-quartile ranges for skewed variables will be used. Participants will be categorised into CFS 1-3, and CFS 4-6. Categorical data will use frequencies and comparison between groups. Change in frailty between the groups over 6 months will be compared using paired t-test. Simple linear regression will be done between frailty measures, arterial stiffness, inflammation and oxidative stress biomarkers. Significance will be at P < .05. Conclusion: This study data will inform a larger, multi-centre study exploring further the interplay between frailty, biomarkers and arterial stiffness parameters.

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“…В настоящее время ухудшение упругоэластических свойств артерий рассматривается как неотъемлемая часть сердечно-сосудистых заболеваний [1,2]. По мнению ряда авторов [3,4], ухудшение упругоэластических свойств аорты является не только причиной таких сердечно-сосудистых заболеваний, как артериальная гипертензия, атеросклероз, хроническая почечная недостаточность, но и причиной таких сердечно-сосудистых осложнений, как инфаркт и инсульт. В силу того, что в настоящее время накоплены сведения о взаимосвязи степени ухудшения упругоэластических свойств грудного отдела аорты с атеросклеротическим поражением коронарных артерий, отдельный интерес представляет оценка упругоэластических свойств аорты у пациентов с гемодинамически значимым коронарным атеросклерозом [5].…”

Section: Introductionunclassified

Clinical-instrumental correlations of local elastic properties of the thoracic aorta in patients with coronary atherosclerosis

Mushkambarov

Beresten

Ткаченко

2020

Regional blood circulation and microcirculation

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Клинико-инструментальные корреляции локальных упругоэластических свойств грудной аорты у пациентов с коронарным атеросклерозом 1 Государственное бюджетное учреждение здравоохранения «Городская клиническая больница имени С. П. Боткина» Департамента здравоохранения города Москвы, Москва, Россия 125284, Россия, Москва, 2-й Боткинский пр-д, д. 5 2 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации,

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Determinants of Arterial Stiffness and Vascular Aging in the Older Adult

Cited by 5 publications

References 0 publications

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

1196 Frailty and Arterial Stiffness - The Role of Oxidative Stress and Inflammation (Fraxi Study)

FRailty and Arterial stiffness – the role of oXidative stress and Inflammation (FRAXI study)

Clinical-instrumental correlations of local elastic properties of the thoracic aorta in patients with coronary atherosclerosis

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