Impacto da Síndrome Metabólica Relacionada à Infecção por Helicobacter pylori Ativa na Hipertensão Arterial Sistêmica

Kountouras, Jannis; Papaefthymiou, Apostolis; Polyzos, Stergios A.; Kazakos, Evangelos; Vardaka, Elisabeth; Touloumtzi, Maria; Tzitiridou‐Chatzopoulou, Maria; Liatsos, Christos; Sgantzou, Ioanna-Konstantina; Knuchel, Jürg; Doulberis, Michael

doi:10.36660/abc.20210931

Cited by 7 publications

(6 citation statements)

References 27 publications

(25 reference statements)

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“…The pathogenesis of hypertension, a component of MS, mainly involves vascular endothelial dysfunction, sympathetic nerve impairment, and the aberrant activation of the renin-angiotensin-aldosterone system ( Gupta et al, 2022 ). Hypertension is also closely related to HP infection ( Dore et al, 2022 ; Fang, Xie & Fan, 2022 ; Kountouras et al, 2022 ). Yue et al (2022) reported that HP infection increased the risk of hypertension by 32%.…”

Section: Survey Methodologymentioning

confidence: 99%

Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection

Xie

Zhou

et al. 2023

PeerJ

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Background Globally, metabolic syndrome (MS) and Helicobacter pylori (HP) infection, which have gained an epidemic status, are major challenges to human health, society, and medical professionals. Recent studies have demonstrated that MS is closely related to HP infection. Additionally, HP is an important risk factor for gastric cancer. However, systematic reviews on HP are lacking. This review aimed to summarize and analyze the potential correlation of HP infection with MS and its components, as well as the underlying mechanism, to provide reference and strategies for clinical prevention and treatment. Methodology Previous studies examining the correlation between HP and MS since 1990 were retrieved from the PubMed, Web of Science, and Embase databases. The potential correlation between HP infection and MS and its components was comprehensively analyzed. The keywords “Helicobacter pylori,” “HP,” “metabolic syndrome,” “hypertension,” “obesity,” “diabetes,” or “dyslipidemia” were used in all fields. No language restrictions were imposed. Results MS was strongly correlated to HP infection. The inflammatory response and inflammatory factors produced during HP infection are important etiological factors for insulin resistance and MS. The co-occurrence of long-term chronic inflammation and immune dysfunction with MS may be the predisposing factor for HP infection. MS components, such as diabetes, hypertension, dyslipidemia, and obesity were also correlated with HP infection in one or both directions. Conclusions HP infection and MS may promote the pathogenesis of each other. The contribution of HP infection and MS to gastric cancer cannot be ruled out based on co-occurrence. The MS components diabetes and obesity may be bidirectionally correlated with HP infection.

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Section: Survey Methodologymentioning

confidence: 99%

Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection

Xie

Zhou

et al. 2023

PeerJ

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“…Atrial fibrillation (AF) significantly contributes to the morbidity and mortality associated with H. pylori/MetS-related C-CVD [25], especially due to strokes caused by AF, which are similarly related to H. pylori infection/MetS [84]. AF is among the leading causes of stroke related to H. pylori infection and MetS [85].…”

Section: The Role Of H Pylori/mets-related Atrial Fibrillation Pathol...mentioning

confidence: 99%

“…Augmented maternal mortality and low fetal birth weight are observed in patients with AF during pregnancy (Figure 1), with an AF peak at the end of the second trimester [98]. AF causes significant morbidity in women and is typically attributed to cardiac remodeling from various causes, especially AH [99], which is similarly associated with diverse pathologies related to H. pylori infection/MetS [3,25,29]. Obstetric complications are often observed in individuals with AF.…”

Section: The Role Of H Pylori/mets-related Atrial Fibrillation Pathol...mentioning

confidence: 99%

“…Specifically, MCs could play a pivotal role in the pathophysiology of H. pylori/MetSrelated conditions, including hyperglycemia, obesity, dyslipidemia, IR, T2DM, cardio-metabolic conditions, AD, referred to as "type-3 diabetes", and their complications [135,[138][139][140]. For example, dyslipidemia is strongly linked with H. pylori/MetS, and MC activation, through the release of tryptase and chymase, contributes to dyslipidemia [141], while eradication of H. pylori improves lipid profiles such as fibrinogen, an independent risk factor for MetS-related C-CVD and dementia [25,142].…”

Section: The Role Of H Pylori/mets-related Atrial Fibrillation Pathol...mentioning

confidence: 99%

“…Active H. pylori infection is further implicated in additional MetS-related systemic disorders, particularly cardio-cerebrovascular diseases (C-CVD) and neurodegenerative disorders, which represent ultimate outcomes of MetS [3,25].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

Tzitiridou-Chatzopoulou,

Kazakos,

Orovou

et al. 2024

JCM

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Helicobacter pylori infection, a significant global burden beyond the gastrointestinal tract, has long been implicated in various systemic pathologies. Rising evidence suggests that the bacterium’s intricate relationship with the immune system and its potential to induce chronic inflammation impact diverse pathophysiological processes in pregnant women that may in turn affect the incidence of several adverse pregnancy and neonate outcomes. Helicobacter pylori infection, which has been linked to metabolic syndrome and other disorders by provoking pericyte dysfunction, hyperhomocysteinemia, galectin-3, atrial fibrillation, gut dysbiosis, and mast cell activation pathologies, may also contribute to adverse pregnancy and neonatal outcomes. Together with increasing our biological understanding of the individual and collective involvement of Helicobacter pylori infection-related metabolic syndrome and concurrent activation of mast cells in maternal, fetus, and neonatal health outcomes, the present narrative review may foster related research endeavors to offer novel therapeutic approaches and informed clinical practice interventions to mitigate relevant risks of this critical topic among pregnant women and their offspring.

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Impact of Helicobacter pylori and metabolic syndrome on mast cell activation-related pathophysiology and neurodegeneration

Kountouras,

Boziki,

Kazakos

et al. 2024

Neurochemistry International

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Impacto da Síndrome Metabólica Relacionada à Infecção por Helicobacter pylori Ativa na Hipertensão Arterial Sistêmica

Cited by 7 publications

References 27 publications

Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection

Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

Impact of Helicobacter pylori and metabolic syndrome on mast cell activation-related pathophysiology and neurodegeneration

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