Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection

Abstract

Background Globally, metabolic syndrome (MS) and Helicobacter pylori (HP) infection, which have gained an epidemic status, are major challenges to human health, society, and medical professionals. Recent studies have demonstrated that MS is closely related to HP infection. Additionally, HP is an important risk factor for gastric cancer. However, systematic reviews on HP are lacking. This review aimed to summarize and analyze the potential correlation of HP infection with MS and its components, as well as the underlying mechanism, to provide reference and strategies for clinical prevention and treatment. Methodology Previous studies examining the correlation between HP and MS since 1990 were retrieved from the PubMed, Web of Science, and Embase databases. The potential correlation between HP infection and MS and its components was comprehensively analyzed. The keywords “Helicobacter pylori,” “HP,” “metabolic syndrome,” “hypertension,” “obesity,” “diabetes,” or “dyslipidemia” were used in all fields. No language restrictions were imposed. Results MS was strongly correlated to HP infection. The inflammatory response and inflammatory factors produced during HP infection are important etiological factors for insulin resistance and MS. The co-occurrence of long-term chronic inflammation and immune dysfunction with MS may be the predisposing factor for HP infection. MS components, such as diabetes, hypertension, dyslipidemia, and obesity were also correlated with HP infection in one or both directions. Conclusions HP infection and MS may promote the pathogenesis of each other. The contribution of HP infection and MS to gastric cancer cannot be ruled out based on co-occurrence. The MS components diabetes and obesity may be bidirectionally correlated with HP infection.

Predictive factors and model validation of post-colon polyp surgery Helicobacter pylori infection

“…Consequently, the immune microenvironment of obese patients creates favorable conditions for the survival of H. pylori ; thus, obese people are more likely to be infected with H. pylori. This is similar to the findings of Xie et al [ 18 ] Additionally, changes in the intragastric microenvironment due to H. Pylori may lead to intestinal microecological disorders, further affecting the intestinal microecology of the patients. This may lead to intestinal tumor-like lesions and adenomatous polyps[ 19 ].…”

The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes

“…MetS typically includes abdominal obesity, insulin resistance (IR), type 2 diabetes mellitus (T2DM), dyslipidemia, nonalcoholic fatty liver disease (NAFLD), arterial hypertension (AH), and cardiovascular disease (CVD) [10]. Emerging evidence highlights a strong connection between MetS and active H. pylori infections, with both disorders appearing to mutually influence their pathophysiology [11]. This infection is associated with MetS [12], and its eradication positively impacts MetS components [13].…”

Diagnóstico serológico de Helicobacter Pylori: Enfoque desde la atención primaria

“…La infección por Helicobacter pylori (HP), es considerada a nivel mundial como unas de las grandes epidemias, con desafíos e impactos en varias dimensiones: para la salud humana, la sociedad e involucrando también a los profesionales médicos (Xie et al, 2023). Es considerada en el contexto de las infecciones, unas de las que alcanza mayor tasa de prevalencia a nivel mundial, reportándose cifras desde el 10% hasta más del 80% de la población, lo cual va a depender de la región estudiada; estudios epidemiológicos realizados en España han reportado una afectación del 50% de la población (Garcés-Durán et al, 2023).…”