Níveis de Tiol Sérico e Homeostase Tiol/Dissulfeto em Pacientes com Doença Valvar Mitral Reumatismal e em Sujeitos Saudáveis

Korkmaz, Ahmet; Doğanay, Birsen; Başyiğit, Funda; Çöteli, Cem; Yıldız, Abdülkadir; Gürsoy, Tuğba; Güray, Ümit; Elalmış, Özgül Uçar

doi:10.36660/abc.20200161

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Thiols are organic compounds that are highly reactive and participate in immune regulation under physiological conditions [ 7 , 22 , 28 ], when the thiol in the reduced form is predominant in plasma. Oxidative stress, characterized by excessive production of ROS, intensifies redox reactions, modifying thiols and giving rise to oxidized products, such as thiol-disulfide, which are related to chronic diseases [ 10 , 22 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Thiols as a marker of inflammatory bowel disease activity: a systematic review

et al. 2023

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Background Evidence indicates that inflammation in Inflammatory Bowel Disease (IBD) is associated with increased systemic levels of reactive oxygen species. Systemic oxidative stress has been associated with reduced levels of plasma thiols. Less invasive tests capable of reflecting and predicting IBD activity are increasingly sought after. We sought to systematically review the evidence inherent in serum thiol levels as a marker of Crohn's Disease and Ulcerative Colitis activity (PROSPERO: CRD42021255521). Methods The highest quality documents for systematic reviews standards were used as reference. Articles were searched on Medline via PubMed, VHL, LILACS, WOS, EMBASE, SCOPUS, COCHRANE, CINAHL, OVID, CTGOV, WHO/ICTRP, OPENGREY, BDTD and CAPES, between August, 03 and September, 03 on 2021. Descriptors were defined according to the Medical Subject Heading. Of the 11 articles selected for full reading, 8 were included in the review. It was not possible to perform a pooled analysis of the studies, as there were no combinable studies between subjects with active IBD and controls/inactive disease. Results Findings from the individual studies included in this review suggest an association between disease activity and systemic oxidation, as measured by serum thiol levels, however, there are limitations that preclude weighting the study results in a meta-analysis. Conclusions We recommend conducting better-designed and controlled studies, that include individuals of both phenotypes and at different stages of IBD, involving a larger number of participants, using the standardization of the technique for measuring serum thiols, to confirm whether thiols can be a good parameter for monitoring the clinical course of these intestinal diseases and the degree of clinical applicability.

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Section: Discussionmentioning

confidence: 99%

Thiols as a marker of inflammatory bowel disease activity: a systematic review

et al. 2023

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Thiols as a Marker of Inflammatory Bowel Disease Activity: A Systematic Review with Meta-analysis

Passos

Costa

Lima

et al. 2022

Preprint

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Background Evidence indicates that inflammation in Inflammatory Bowel Disease (IBD) is associated with increased systemic levels of reactive oxygen species. Systemic oxidative stress has been associated with reduced levels of plasma thiols. Less invasive tests capable of reflecting and predicting IBD activity are increasingly sought after. In this sense, we sought to systematically review the evidence inherent in serum thiol levels as a marker of Crohn's Disease and Ulcerative Colitis activity (PROSPERO: CRD42021255521). Methods The highest quality documents for systematic reviews and meta-analyses standards were used as reference. The highest quality documents for systematic reviews and meta-analyses standards were used as reference. Articles were searched on Medline via PubMed and via Central, VHL, LILACS, WOS, EMBASE, SCOPUS, COCHRANE, CINAHL, OVID, CTGOV, WHO/ICTRP, OPENGREY, BDTD and CAPES, between August and September/2021. Descriptors were defined according to the Medical Subject Heading.The articles were searched between August and September/2021. Of the 11 articles selected for full reading, 7 were included in the review. Of these, 4 were combinable studies and were included in the meta-analysis. Results The findings of the individual studies included suggest an association between disease activity and systemic oxidation, as measured by serum thiol levels, however, the pooled analysis did not identify a significant association between the parameters evaluated. The limitations identified in this meta-analysis made it impossible to weigh the results of individual studies, which, associated with potential confounding factors, may have interfered with the results of the grouped assessment. Conclusions We recommend conducting randomized clinical trials, with individuals of both phenotypes and in different stages of IBD, involving larger numbers of participants, using standardization of the technique for measuring serum thiols, in order to confirm whether thiols can be a good parameter of monitoring the clinical course of these intestinal diseases and the degree of clinical applicability.

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The Role of Inflammation and Oxidative Stress in Rheumatic Heart Disease

Franczyk

Gluba-Brzózka

Rysz-Górzyńska

et al. 2022

IJMS

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Rheumatic heart disease (RHD), an acquired valvular disease, remains an important cause of morbidity and mortality in developing countries. This chronic illness starts from untreated streptococcal throat infection, resulting in acute rheumatic fever (ARF) in susceptible individuals. Repeated infections lead to a chronic phase characterized by the damage of heart valves. Inflammation has been found to play important role in the development of this disease. All the studies presented in this review clearly show the involvement of the inflammatory state in the progression of this disease. However, the exact role of cytokines in inflammation sites remains to be examined, since most studies have so far focused on peripheral blood. Such analysis would provide information on inflammatory mechanisms in situ.

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Níveis de Tiol Sérico e Homeostase Tiol/Dissulfeto em Pacientes com Doença Valvar Mitral Reumatismal e em Sujeitos Saudáveis

Cited by 3 publications

References 31 publications

Thiols as a marker of inflammatory bowel disease activity: a systematic review

Thiols as a marker of inflammatory bowel disease activity: a systematic review

Thiols as a Marker of Inflammatory Bowel Disease Activity: A Systematic Review with Meta-analysis

The Role of Inflammation and Oxidative Stress in Rheumatic Heart Disease

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