Protective mechanical ventilation in patients with risk factors for ARDS: prospective cohort study

Ventilation during Lung Resection and Critical Care: Comparative Clinical Outcomes

“…Although low V T ventilation has been associated with a lower risk of ventilator-associated lung injury, it might contribute to ventilator dyssynchrony, delirium, atelectasis, and pulmonary dead space ventilation with hypercarbia. The findings of retrospective [13][14][15][16][17][18][19] and prospective [20][21][22][23][24][25] studies of ventilation of ICU patients without ARDS (i.e., with healthy lungs) are summarized in table 1. Our discussion of ICU patients without ARDS is limited to contemporary prospective trials.…”

Caring for patients at risk of ARDS: the role of driving pressure

“…The role of lung-protective strategies in patients without ARDS is less conclusive. 10 In this issue of the Jornal Brasileiro de Pneumologia , Bastos-Netto et al 11 provide important data regarding the impact of lung-protective strategies in patients without ARDS at baseline who presented with risk factors for the disease. In a cohort of 116 patients on MV, the authors found that patients with maximum distending pressures < 15 cmH 2 O had a lower 28-day mortality rate.…”

“…Bastos-Netto et al 11 have taken an important step toward a better understanding of the determinants of poor outcomes in patients under MV. As new evidence reveals the importance of driving pressure, we should be able to see more of its effects in unforeseen scenarios.…”