The role of adiponectin in ischemia-reperfusion syndrome: a literature review

Carballo, Mariela Carolina Santos; Pinto, Luís Cláudio Santos; Brito, Marcus Vinicius Henriques

doi:10.31744/einstein_journal/2020rw5160

Einstein (São Paulo)

2020

DOI: 10.31744/einstein_journal/2020rw5160

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The role of adiponectin in ischemia-reperfusion syndrome: a literature review

Mariela Carolina Santos Carballo¹,

Luís Cláudio Santos Pinto²,

Marcus Vinicius Henriques Brito³

Abstract: Adiponectin, among other diverse adipokines, is produced in greater quantity and has an effect on the adipose tissue and other tissues in the body. Adiponectin plays three main roles: regulatory metabolic and sensitizing function of insulin in the liver and muscles; it acts as an anti-inflammatory cytokine and in vascular protection, besides important cardiac protection in the presence of ischemia-reperfusion syndrome. Since many situations resulting from traumatic accidents or pathologies are due to cell dama… Show more

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“…In adipocytes, adipokines such as adiponectin and leptin are produced to modulate glucose and lipid metabolism. [25][26][27][28] It is not clear whether LAA influences their level long-term in patients undergoing this procedure.…”

mentioning

confidence: 99%

Metabolic effects of the left atrial appendage exclusion (the heart hormone study)

Bartuś

Elbey

Kanuri

et al. 2022

Cardiovasc electrophysiol

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Introduction The effect of epicardial left atrial appendage (LAA) occlusion therapy on lipid and glucose metabolism in atrial fibrillation (AF) patients over the long‐term follow‐up are unclear. Methods In a single‐center prospective observational study, 60 patients with longstanding persistent AF with cardiovascular risk factors had undergone an epicardial exclusion procedure. Anthropometric parameters and glucose, glycated hemoglobin (HbA1c), insulin, leptin, adiponectin, free fatty acids, beta‐hydroxybutyrate, and total cholesterol levels were evaluated on fasting at baseline before the procedure and compared with levels at 24 h, 7 days, 1, 3, 6, and 24 months follow the procedure. Results The mean age of the patients was 67.5 ± 8.1. Insulin levels significantly increased at 7 days, 1, 3, 6, 12, and 24 months follow‐up. The leptin levels showed a significant increase in 6, 12, and 24 months when compared to baseline. Whereas the adiponectin levels showed a significant decrease at 3, 6, 12, and 24 months when compared to baseline levels. In patients with the epicardial procedure, when compared to baseline, glucose, glycated hemoglobin, total cholesterol, and beta‐hydroxybutyrate levels did not show any significant changes at baseline and 24 months follow‐up. Conclusion The epicardial exclusion ligation in AF patients was associated with significant changes in insulin, leptin, and adiponectin over long follow‐up.

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mentioning

confidence: 99%

Metabolic effects of the left atrial appendage exclusion (the heart hormone study)

Bartuś

Elbey

Kanuri

et al. 2022

Cardiovasc electrophysiol

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APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats

Pei

et al. 2023

Cells

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Adiponectin (APN) is an essential adipokine for a variety of reproductive processes. To investigate the role of APN in goat corpora lutea (CLs), CLs and sera from different luteal phases were collected for analysis. The results showed that the APN structure and content had no significant divergence in different luteal phases both in CLs and sera; however, high molecular weight APN was dominant in serum, while low molecular weight APN was more present in CLs. The luteal expression of both AdipoR1/2 and T-cadherin (T-Ca) increased on D11 and 17. APN and its receptors (AdipoR1/2 and T-Ca) were mainly expressed in goat luteal steroidogenic cells. The steroidogenesis and APN structure in pregnant CLs had a similar model as in the mid-cycle CLs. To further explore the effects and mechanisms of APN in CLs, steroidogenic cells from pregnant CLs were isolated to detect the AMPK-mediated pathway by the activation of APN (AdipoRon) and knockdown of APN receptors. The results revealed that P-AMPK in goat luteal cells increased after incubation with APN (1 μg/mL) or AdipoRon (25 μM) for 1 h, and progesterone (P4) and steroidogenic proteins levels (STAR/CYP11A1/HSD3B) decreased after 24 h. APN did not affect the steroidogenic protein expression when cells were pretreated with Compound C or SiAMPK. APN increased P-AMPK and reduced the CYP11A1 expression and P4 levels when cells were pretreated with SiAdipoR1 or SiT-Ca, while APN failed to affect P-AMPK, the CYP11A1 expression or the P4 levels when pretreated with SiAdipoR2. Therefore, the different structural forms of APN in CLs and sera may possess distinct functions; APN might regulate luteal steroidogenesis through AdipoR2 which is most likely dependent on AMPK.

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The role of adiponectin in ischemia-reperfusion syndrome: a literature review

Cited by 2 publications

References 39 publications

Metabolic effects of the left atrial appendage exclusion (the heart hormone study)

Metabolic effects of the left atrial appendage exclusion (the heart hormone study)

APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats

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