COVID-19 and coinfection with Clostridioides ( Clostridium ) difficile in an infant with gastrointestinal manifestation

Oba, Jane; Silva, Clóvis A.; Toma, Ricardo Katsuya; Carvalho, Werther Brunow de; Delgado, Artur Figueiredo

doi:10.31744/einstein_journal/2020rc6048

Cited by 9 publications

(12 citation statements)

References 10 publications

(32 reference statements)

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“…The increase in Clostridium ramosum and Clostridium hathewayi is associated with the disease severity which may be a risk factor of acute portal vein thrombosis (Zuo et al, 2020;Rokkam et al, 2021). Clostridium difficile may complicate COVID-19 and worsen the GI symptoms (Ferreira et al, 2020;Oba et al, 2020;Sandhu et al, 2020;Khanna and Kraft, 2021). Two butyrate-producing members of this genus, Clostridium butyricum and Clostridium leptum, are decreased in patients with COVID-19 (Tang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review

Farsi

Tahvildari

Arbabi

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionThe Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) emerged in late December 2019. Considering the important role of gut microbiota in maturation, regulation, and induction of the immune system and subsequent inflammatory processes, it seems that evaluating the composition of gut microbiota in COVID-19 patients compared with healthy individuals may have potential value as a diagnostic and/or prognostic biomarker for the disease. Also, therapeutic interventions affecting gut microbial flora may open new horizons in the treatment of COVID-19 patients and accelerating their recovery.MethodsA systematic search was conducted for relevant studies published from December 2019 to December 2021 using Pubmed/Medline, Embase, and Scopus. Articles containing the following keywords in titles or abstracts were selected: “SARS-CoV-2” or “COVID-19” or “Coronavirus Disease 19” and “gastrointestinal microbes” or “dysbiosis” or “gut microbiota” or “gut bacteria” or “gut microbes” or “gastrointestinal microbiota”.ResultsOut of 1,668 studies, 22 articles fulfilled the inclusion criteria and a total of 1,255 confirmed COVID-19 patients were examined. All included studies showed a significant association between COVID-19 and gut microbiota dysbiosis. The most alteration in bacterial composition of COVID-19 patients was depletion in genera Ruminococcus, Alistipes, Eubacterium, Bifidobacterium, Faecalibacterium, Roseburia, Fusicathenibacter, and Blautia and enrichment of Eggerthella, Bacteroides, Actinomyces, Clostridium, Streptococcus, Rothia, and Collinsella. Also, some gut microbiome alterations were associated with COVID-19 severity and poor prognosis including the increment of Bacteroides, Parabacteroides, Clostridium, Bifidobacterium, Ruminococcus, Campylobacter, Rothia, Corynebacterium, Megasphaera, Enterococcus, and Aspergillus spp. and the decrement of Roseburia, Eubacterium, Lachnospira, Faecalibacterium, and the Firmicutes/Bacteroidetes ratio.ConclusionOur study showed a significant change of gut microbiome composition in COVID-19 patients compared with healthy individuals. This great extent of impact has proposed the gut microbiota as a potential diagnostic, prognostic, and therapeutic strategy for COVID-19. There is much evidence about this issue, and it is expected to be increased in near future.

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Section: Discussionmentioning

confidence: 99%

Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review

Farsi

Tahvildari

Arbabi

et al. 2022

Front. Cell. Infect. Microbiol.

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“…(9,12,18,21,31) The viral RNA was not identified in other samples (94.29%). (8)(9)(10)12,16,18,19,25,26,(28)(29)(30) In the study by Chambers et al (18) 64 samples of breast milk from 18 women diagnosed with COVID-19 were analyzed; however, despite having detected SARS-CoV-2 RNA in one sample, the viral culture for this same sample was negative.…”

Section: ❚ Resultsmentioning

confidence: 99%

“…(27) Breastfeeding is also a protective factor in cases of co-infection by other pathogens, such as Clostridioides difficile. (26)…”

Section: ❚ Resultsmentioning

confidence: 99%

Breastfeeding during the COVID-19 pandemic: what do we know so far?

Natarelli¹,

Brassarola²,

Fonseca³

2022

Einstein (São Paulo)

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Objective This study aimed to conduct a literature review on safety in breastfeeding in mothers with COVID-19. An integrative review of national and international literature was carried out. Methods The search took place in the SciELO, LILACS and MEDLINE ® databases. Results A total of 25 scientific articles that specifically addressed the theme of breastfeeding and its risk and protective factors for infection by SARS-CoV-2 were selected. According to the studies analyzed, although the presence of viral RNA had already been detected by reverse transcriptase polymerase chain reaction in breast milk samples, there are still no proven cases of vertical transmission via human milk. Conclusion Breastfeeding appears to be safe if practiced according to precaution measures recommended by the World Health Organization. In addition, there is evidence of a potential for immunological protection by transfer of antibodies against SARS-CoV-2 in breast milk. Breastfeeding should continue to be promoted even in cases of mothers with clinical suspicion or confirmation of COVID-19, as well as the provision of expressed breast milk in cases where there is no possibility of direct breastfeeding.

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“…Cerca de 10% dos pacientes evoluem somente com sintomas gastrointestinais, sem apresentar manifestações respiratórias 19 . Em alguns dos relatos de casos abordados por nossa pesquisa, as MGI foram identificadas como primeiras manifestações da doença 12,13,15,17 . Além disso, as MGI tem sido associadas a maior severidade da infecção, demora na admissão hospitalar e maior tempo entre o início dos sintomas e o clearance viral 20 .…”

Section: Discussionunclassified

“…Houve remissão de dor abdominal após 9 dias, tendo sido realizado tratamento de suporte, sem antibioticoterapia. Durante investigação, foi identificado em fezes RT-PCR positivo para SARS-CoV-2 no dia da admissão e com 27 dias após internação, além de também terem encontrado PCR positivo para C. difficile 17 .…”

Section: Pediatriaunclassified

Manifestações gastrointestinais em pacientes pediátricos com infecção por coronavírus no Brasil

Pontes¹,

Vasques²,

Oliveira³

2021

PRMJ

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COVID-19 and coinfection with Clostridioides ( Clostridium ) difficile in an infant with gastrointestinal manifestation

Abstract: COVID-19 and coinfection with Clostridioides (Clostridium) difficile in an infant with gastrointestinal manifestation COVID-19 e coinfecção por Clostridioides (Clostridium) difficile em lactente com manifestações gastrintestinais

Cited by 9 publications

References 10 publications

Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review

Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review

Breastfeeding during the COVID-19 pandemic: what do we know so far?

Manifestações gastrointestinais em pacientes pediátricos com infecção por coronavírus no Brasil

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