Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly

Gonçalves, Sandra Elisa Adami Batista; Ribeiro, Andreza Alice Feitosa; Hirose, Erika Yuri; Santos, Fábio Pires de Souza; Ferreira, Flavia Munhoz; Koch, Ludmila de Oliveira; Tanaka, M; Souza, M.S.; Souza, Polianna Mara Rodrigues de; Gonçalves, Thiago José Martins; Pereira, Andréa Z

doi:10.31744/einstein_journal/2019ae4340

Cited by 4 publications

(3 citation statements)

References 126 publications

(165 reference statements)

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“…65 The nutritional and body composition profile should be analyzed for the elderly patient before and after HSCT for managing their treatment and hospitality. 65 Exercise, as supportive care for HSCT patients, has a significant benefit for physical performance and results in the rapid recovery of the immune system and reducing the side effect of the therapy. 66 Furthermore, improvement of QOL, especially emotional aspects, is attributed to exercising before and after HSCT.…”

Section: Weight Nutrition and Exercisementioning

confidence: 99%

“…Nutritional status by quantification of albumin and BMI is generally used for evaluation of overall health, and it has been reported that pretransplant BMI < 18.5 kg/m 2 is associated with the higher risk of relapse, the TRM, as well as the lower survival 20 . Regarding the progressive increase in adipose and decrease in muscular tissue during adulthood and the elderly, patients at nutritional risk or poor nutrition status should be recognized, that the best chemotherapy regimens would be decided for them, as these patients are at the risk of chemotherapy‐related toxicity 65 . The nutritional and body composition profile should be analyzed for the elderly patient before and after HSCT for managing their treatment and hospitality 65 .…”

Section: Survivalmentioning

confidence: 99%

“…Regarding the progressive increase in adipose and decrease in muscular tissue during adulthood and the elderly, patients at nutritional risk or poor nutrition status should be recognized, that the best chemotherapy regimens would be decided for them, as these patients are at the risk of chemotherapy‐related toxicity 65 . The nutritional and body composition profile should be analyzed for the elderly patient before and after HSCT for managing their treatment and hospitality 65 . Exercise, as supportive care for HSCT patients, has a significant benefit for physical performance and results in the rapid recovery of the immune system and reducing the side effect of the therapy 66 .…”

Section: Survivalmentioning

confidence: 99%

See 2 more Smart Citations

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Rafiee

Abbasi

Rafieemehr

et al. 2021

Health Science Reports

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Background and aims As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non‐hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes. Methods We had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included. Results Here we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdisease, and Mobilization. Also, the prediction of hematological reconstitutionand some novel suggestions leading to better outcomes are reviewed. Conclusion The study will be applicable for improvedmanagement of autologous and allogeneic HSCT process to increase the procedureefficiency.

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Section: Weight Nutrition and Exercisementioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

See 1 more Smart Citation

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Rafiee

Abbasi

Rafieemehr

et al. 2021

Health Science Reports

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Impact of functional capacity before hematopoietic stem cell transplantation on the length of hospital stay

Penna,

Silva,

Pedroni

et al. 2023

Preprint

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Objective: To verify the association between pre-HSCT functional capacity and the variables of pulmonary function, fatigue and length of hospital stay. Methods: This is a cohort study, involving patients admitted to the Bone Marrow Transplantation. The individuals were submitted to an evaluation in the first 24 hours of hospitalization. The length of stay variable was checked on the day of hospital discharge. Functional capacity was assessed through the 6MWT, the 30-second sit-to-stand test (TSL30) was performed to assess the indirect strength of the lower limbs, moreover was used Revised Piper Fatigue Scale and evaluation of the pulmonary function. Results: The sample consisted of thirty-five individuals (19 male; 54%). Fourteen patients achieved a 6MWT ≥80% predicted. The mean age of the sample was 45.5 ± 15.2 years, and BMI 27.4 ± 5.4 kg/m². Patients who completed a 6MWD below the predicted value showed significantly lower pulmonary function values for the variables PEF(%) (p=0.031), FEV1 (%) (p=0.033) and FEV1/FVC(%) (p=0.027) in relation to the group with better functional capacity. This group showed significantly higher values in the assessment of lower limb fatigue using the Borg scale pre (p=0.008) and post (p=0.004) 6MWT, longer hospitalization time (p=0.0014), but with no significant difference in lower limb muscle strength between groups (p=0.21). A moderate correlation was found between the 6MWD% and FEV1% (p<0.05). Conclusion: Data indicate that starting HSCT treatment with lower-than-expected physical fitness is associated with lower lung function, greater fatigue in the lower limbs, and longer hospital stays.

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Umbilical Cord Blood-Derived Mesenchymal Stem Cells Transplantation Decreases Incidence of Liver Cancer in End-Stage Liver Disease Patients: A Retrospective Analysis Over 5 Years

Luo

Lai

Tian

et al. 2021

Preprint

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Background: End-stage liver disease (ESLD) is the final stage of a liver disease, which is characterized by liver cirrhosis. ESLD largely increases possibility of liver cancers in the world. The stem cell transplantation has become an emerging therapy to treat various liver diseases including ESLD, while whether it causes liver cancer remains unclear. The study aims to analysis the long-term therapeutic effect of umbilical cord blood-derived mesenchymal stem cells (UC-MSCs) transplantation in ESLD patients. Patients and Methods: 50 ELSD patients of non-UC-MSCs transplantation and 45 ELSD patients of UC-MSCs transplantation were retrospectively analyzed. The clinical outcomes in clinical and biochemical data, complications, and quality of life were recorded at 3, 6, 12, 36, and 60 months. Results: It was found that the incidence of liver cancer was much lower in ESLD patients with UC-MSCs transplantation than in ESLD patients without UC-MSCs transplantation (12% VS 2.2%). The survival percentage was improved by treatment with UC-MSCs transplantation compared with non-UC-MSCs transplantation in ESLD patients during the five years follow-up. The inflammation and fibrosis scores were decreased in the ESLD patients with UC-MSCs transplantation. The liver cirrhosis was largely improved, and Child-Pugh scores were decreased. Conclusions: UC-MSCs transplantation is able to decrease the risks of liver cancers in ELSD patients. The reduction of liver cancer incidence might be related to decrease of inflammation by UC-MSCs transplantation. More efforts should be investigated towards increasing the number of patients and follow-up time to further verify the therapeutic benefits of UC-MSCs translations in treating liver cancers.

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Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly

Cited by 4 publications

References 126 publications

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Impact of functional capacity before hematopoietic stem cell transplantation on the length of hospital stay

Umbilical Cord Blood-Derived Mesenchymal Stem Cells Transplantation Decreases Incidence of Liver Cancer in End-Stage Liver Disease Patients: A Retrospective Analysis Over 5 Years

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